Reviewed, UniProtKB/Swiss-Prot Q2KIA5 (DNM1L_BOVIN)

Names and origin

Protein names

Recommended name:
    Dynamin-1-like protein
    EC=3.6.5.5

Gene names

Name:

DNM1L

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	749 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Functions in mitochondrial and peroxisomal division probably by regulating membrane fission. Enzyme hydrolyzing GTP that oligomerizes to form ring-like structures and is able to remodel membranes. May also play a role on organelles of the secretory pathway By similarity.
Catalytic activity	GTP + H2O = GDP + phosphate.
Subunit structure	Homotetramer; N-terminal part binds to the C-terminal part of another DNM1L. Can self-assemble in multimeric ring-like structures. Interacts with GSK3B and FIS1 By similarity.
Subcellular location	Cytoplasm › cytosol By similarity. Endomembrane system; Peripheral membrane protein By similarity. Note: Mainly cytosolic By similarity. Also membrane-associated. Localizes to mitochondria at spots of division events. Associated with peroxisomal membranes, it is recruited in part by PEX11B. May also be associated with endoplasmic reticulum tubules and cytoplasmic vesicles and found to be perinuclear By similarity.
Post-translational modification	Phosphorylated by GSK3B By similarity.
Sequence similarities	Belongs to the dynamin family. Contains 1 GED domain.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Ligand	GTP-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Cellular component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 749	749	Dynamin-1-like protein		PRO_0000284972
Regions
	Domain	657 – 748	92	GED
	Nucleotide binding	32 – 39	8	GTP By similarity
	Nucleotide binding	159 – 163	5	GTP By similarity
	Nucleotide binding	228 – 231	4	GTP By similarity
	Region	1 – 356	356	N-terminal dimerization domain By similarity
	Region	461 – 698	238	Interaction with GSK3B By similarity
	Region	555 – 749	195	C-terminal dimerization domain By similarity
Amino acid modifications
	Modified residue	296	1	N6-acetyllysine By similarity
	Modified residue	542	1	Phosphoserine By similarity
	Modified residue	561	1	Phosphoserine By similarity
	Modified residue	629	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2KIA5-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: BA90863E8BC8265B	FASTA	749	83,352
	10 20 30 40 50 60 MEALIPVINK LQDVFNTVGA DIIQLPQIVV VGTQSSGKSS VLESLVGRDL LPRGTGIVTR 70 80 90 100 110 120 RPLILQLVHV APEDKRKTTG EENDPATWKN SRHLSKGVEA EEWGKFLHTK NKLYTDFDEI 130 140 150 160 170 180 RQEIENETER ISGNNKGVSP EPIHLKIFSP NVVNLTLVDL PGMTKVPVGD QPKDIELQIR 190 200 210 220 230 240 ELILRFISNP NSIILAVTAA NTDMATSEAL KISREVDPDG RRTLAVITKL DLMDAGTDAM 250 260 270 280 290 300 DVLMGRVIPV KLGIIGVVNR SQLDINNKKS VTDSIRDEYA FLQKKYPSLA NRNGTKYLAR 310 320 330 340 350 360 TLNRLLMHHI RDCLPELKTR INVLAAQYQS LLNSYGEPVD DKSATLLQLI TKFATEYCNT 370 380 390 400 410 420 IEGTAKYIET SELCGGARIC YIFHETFGRT LESVDPLGGL NTIDILTAIR NATGPRPALF 430 440 450 460 470 480 VPEVSFELLV KRQIKRLEEP SLRCVELVHE EMQRIIQHCS NYSTQELLRF PKLHDAIVEV 490 500 510 520 530 540 VTCLLRKRLP VTNEMVHNLV AIELAYINTK HPDFADACGL MNNNIEEQRR NRLARELPSA 550 560 570 580 590 600 VSRDKSSKVP SALAPASQEP SPAASAEADG KLIQESRRET KNAASGGGGV GDAVQEPTTG 610 620 630 640 650 660 NWRGMLKTSK AEELLAEEKS KPIPIMPASP QKGHAVNLLD VPVPVARKLS AREQRDCEVI 670 680 690 700 710 720 ERLIKSYFLI VRKNIQDSVP KAVMHFLVNH VKDTLQSELV GQLYKSSLLD DLLTESEDMA 730 740 QRRKEAADML KALQGASQII AEIRETHLW

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Hypothalamus.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC112710 mRNA. Translation: AAI12711.1.
IPI	IPI00706292.
RefSeq	NP_001039959.1.
UniGene	Bt.87451
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000037956; ENSBTAP00000037777; ENSBTAG00000011395; Bos taurus. [Genome view] ENSBTAT00000056043; ENSBTAP00000051214; ENSBTAG00000011395; Bos taurus. [Genome view]
GeneID	540892.
KEGG	bta:540892.
Organism-specific databases
CTD	540892.
Phylogenomic databases
HOVERGEN	Q2KIA5.
Enzyme and pathway databases
BRENDA	3.6.5.5. 251.
Family and domain databases
InterPro	IPR000375. Dynamin_central. IPR001401. Dynamin_GTPase. IPR019762. Dynamin_GTPase_CS. IPR003130. GED. [Graphical view]
Pfam	PF01031. Dynamin_M. 1 hit. PF00350. Dynamin_N. 1 hit. PF02212. GED. 1 hit. [Graphical view]
PRINTS	PR00195. DYNAMIN.
SMART	SM00053. DYNc. 1 hit. SM00302. GED. 1 hit. [Graphical view]
PROSITE	PS00410. DYNAMIN. 1 hit. PS51388. GED. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNM1L_BOVIN

Accession

Primary (citable) accession number: Q2KIA5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	March 7, 2006
Last modified:	October 13, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)