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Reviewed, UniProtKB/Swiss-Prot Q2KIA4 (SCD5_BOVIN)

Last modified June 16, 2009. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Stearoyl-CoA desaturase 5
    EC=1.14.19.1
Alternative name(s):
    Acyl-CoA-desaturase 4
    Stearoyl-CoA 9-desaturase
Gene names
Name: SCD5
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Fatty acid delta(9)-desaturase that introduces a double bond in fatty acyl-coenzyme A at the delta 9 position By similarity.

Catalytic activity

Stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O.

Cofactor

Iron By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Detected in brain. Ref.1

Domain

The histidine box domains may contain the active site and/or be involved in metal ion binding By similarity.

Sequence similarities

Belongs to the fatty acid desaturase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 335335Stearoyl-CoA desaturase 5
PRO_0000312652

Regions

Transmembrane55 – 7521 Potential
Transmembrane78 – 9821 Potential
Transmembrane199 – 21921 Potential
Transmembrane228 – 24720 Potential
Motif99 – 1046Histidine box-1 By similarity
Motif136 – 1405Histidine box-2 By similarity
Motif277 – 2815Histidine box-3 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2KIA4-1 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: 32F8B2C60533AB31

FASTA33538,215
        10         20         30         40         50         60 
MPGPAVDAEK VPFRSAKEEI RAGVGVEGSE GGGGGGGRER PGARGHRQDI VWRNVFLMSL 

        70         80         90        100        110        120 
LHLAAVYSLV LIPKAQPLTL LWAYFCFLLT ALGVTAGAHR LWSHRSYKAK LPLRIFLAAA 

       130        140        150        160        170        180 
NSMAFQNDIF EWSRDHRVHH KYSETDADPH NARRGFFFSH IGWLFVRKHR DVIEKGRKLD 

       190        200        210        220        230        240 
VTDLLADPVV RFQRKYYKIT VVLMCFVVPT LVPWYIWGES LWNSYFLASI LRYTISLNVT 

       250        260        270        280        290        300 
WLVNSVAHMY GNRPYDKHIS PRQNPLVTLG AIGEGFHNYH HTFPFDYSAS EFGLNFNPTT 

       310        320        330 
WFIDFMCWLG LATDRKRATK QMIEARKART GDGSA 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of a novel bovine stearoyl-CoA desaturase isoform with homology to human SCD5."
Lengi A.J., Corl B.A.
Lipids 42:499-508(2007) [PubMed: 17468887] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Hypothalamus.

Cross-references

Sequence databases

EF014951 mRNA. Translation: ABJ99757.1.
BC112711 mRNA. Translation: AAI12712.1.
IPIIPI00716739.
RefSeqNP_001070413.1.
UniGeneBt.13249

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSBTAG00000022449. Bos taurus. [Contig view]
GeneID617419.
KEGGbta:617419.

Phylogenomic databases

HOVERGENQ2KIA4.
OMAQ2KIA4. CFFISAL.

Enzyme and pathway databases

BRENDA1.14.19.1. 251.

Family and domain databases

InterProIPR005804. Fatty_acid_desaturase-1.
IPR001522. Fatty_acid_desaturase-1_C.
IPR015876. Fatty_acid_desaturase-1_core.
[Graphical view]
PfamPF00487. FA_desaturase. 1 hit.
[Graphical view]
PRINTSPR00075. FACDDSATRASE.
ProDomPD002221. Desaturase. 1 hit.
PD001081. FA_desat_sub. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00476. FATTY_ACID_DESATUR_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSCD5_BOVIN
AccessionPrimary (citable) accession number: Q2KIA4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 7, 2006
Last modified: June 16, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents