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Protein

Stearoyl-CoA desaturase 5

Gene

SCD5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Fatty acid delta(9)-desaturase that introduces a double bond in fatty acyl-coenzyme A at the delta 9 position.By similarity

Catalytic activityi

Stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O.

Cofactori

Fe cationBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.14.19.1. 908.

Names & Taxonomyi

Protein namesi
Recommended name:
Stearoyl-CoA desaturase 5 (EC:1.14.19.1)
Alternative name(s):
Acyl-CoA-desaturase 4
Stearoyl-CoA 9-desaturase
Gene namesi
Name:SCD5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 6

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei55 – 7521HelicalSequence AnalysisAdd
BLAST
Transmembranei78 – 9821HelicalSequence AnalysisAdd
BLAST
Transmembranei199 – 21921HelicalSequence AnalysisAdd
BLAST
Transmembranei228 – 24720HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Stearoyl-CoA desaturase 5PRO_0000312652Add
BLAST

Proteomic databases

PRIDEiQ2KIA4.

Expressioni

Tissue specificityi

Detected in brain.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025820.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi99 – 1046Histidine box-1By similarity
Motifi136 – 1405Histidine box-2By similarity
Motifi277 – 2815Histidine box-3By similarity

Domaini

The histidine box domains may contain the active site and/or be involved in metal ion binding.By similarity

Sequence similaritiesi

Belongs to the fatty acid desaturase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1398.
GeneTreeiENSGT00530000063158.
HOGENOMiHOG000270352.
HOVERGENiHBG003367.
InParanoidiQ2KIA4.
KOiK00507.
OMAiGLWWAHI.
OrthoDBiEOG7ZPNKS.
TreeFamiTF313251.

Family and domain databases

InterProiIPR005804. Fatty_acid_desaturase-1.
IPR001522. Fatty_acid_desaturase-1_C.
IPR015876. Fatty_acid_desaturase-1_core.
[Graphical view]
PfamiPF00487. FA_desaturase. 1 hit.
[Graphical view]
PRINTSiPR00075. FACDDSATRASE.
PROSITEiPS00476. FATTY_ACID_DESATUR_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2KIA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGPAVDAEK VPFRSAKEEI RAGVGVEGSE GGGGGGGRER PGARGHRQDI
60 70 80 90 100
VWRNVFLMSL LHLAAVYSLV LIPKAQPLTL LWAYFCFLLT ALGVTAGAHR
110 120 130 140 150
LWSHRSYKAK LPLRIFLAAA NSMAFQNDIF EWSRDHRVHH KYSETDADPH
160 170 180 190 200
NARRGFFFSH IGWLFVRKHR DVIEKGRKLD VTDLLADPVV RFQRKYYKIT
210 220 230 240 250
VVLMCFVVPT LVPWYIWGES LWNSYFLASI LRYTISLNVT WLVNSVAHMY
260 270 280 290 300
GNRPYDKHIS PRQNPLVTLG AIGEGFHNYH HTFPFDYSAS EFGLNFNPTT
310 320 330
WFIDFMCWLG LATDRKRATK QMIEARKART GDGSA
Length:335
Mass (Da):38,215
Last modified:March 7, 2006 - v1
Checksum:i32F8B2C60533AB31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF014951 mRNA. Translation: ABJ99757.1.
BC112711 mRNA. Translation: AAI12712.1.
RefSeqiNP_001070413.1. NM_001076945.1.
UniGeneiBt.13249.

Genome annotation databases

EnsembliENSBTAT00000025820; ENSBTAP00000025820; ENSBTAG00000022449.
GeneIDi617419.
KEGGibta:617419.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF014951 mRNA. Translation: ABJ99757.1.
BC112711 mRNA. Translation: AAI12712.1.
RefSeqiNP_001070413.1. NM_001076945.1.
UniGeneiBt.13249.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025820.

Proteomic databases

PRIDEiQ2KIA4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000025820; ENSBTAP00000025820; ENSBTAG00000022449.
GeneIDi617419.
KEGGibta:617419.

Organism-specific databases

CTDi79966.

Phylogenomic databases

eggNOGiCOG1398.
GeneTreeiENSGT00530000063158.
HOGENOMiHOG000270352.
HOVERGENiHBG003367.
InParanoidiQ2KIA4.
KOiK00507.
OMAiGLWWAHI.
OrthoDBiEOG7ZPNKS.
TreeFamiTF313251.

Enzyme and pathway databases

BRENDAi1.14.19.1. 908.

Miscellaneous databases

NextBioi20900654.

Family and domain databases

InterProiIPR005804. Fatty_acid_desaturase-1.
IPR001522. Fatty_acid_desaturase-1_C.
IPR015876. Fatty_acid_desaturase-1_core.
[Graphical view]
PfamiPF00487. FA_desaturase. 1 hit.
[Graphical view]
PRINTSiPR00075. FACDDSATRASE.
PROSITEiPS00476. FATTY_ACID_DESATUR_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a novel bovine stearoyl-CoA desaturase isoform with homology to human SCD5."
    Lengi A.J., Corl B.A.
    Lipids 42:499-508(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiSCD5_BOVIN
AccessioniPrimary (citable) accession number: Q2KIA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 7, 2006
Last modified: July 22, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.