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Q2KIA4 (SCD5_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Stearoyl-CoA desaturase 5

EC=1.14.19.1
Alternative name(s):
Acyl-CoA-desaturase 4
Stearoyl-CoA 9-desaturase
Gene names
Name:SCD5
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Fatty acid delta(9)-desaturase that introduces a double bond in fatty acyl-coenzyme A at the delta 9 position By similarity.

Catalytic activity

Stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O.

Cofactor

Iron By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Detected in brain. Ref.1

Domain

The histidine box domains may contain the active site and/or be involved in metal ion binding By similarity.

Sequence similarities

Belongs to the fatty acid desaturase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 335335Stearoyl-CoA desaturase 5
PRO_0000312652

Regions

Transmembrane55 – 7521Helical; Potential
Transmembrane78 – 9821Helical; Potential
Transmembrane199 – 21921Helical; Potential
Transmembrane228 – 24720Helical; Potential
Motif99 – 1046Histidine box-1 By similarity
Motif136 – 1405Histidine box-2 By similarity
Motif277 – 2815Histidine box-3 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2KIA4 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: 32F8B2C60533AB31

FASTA33538,215
        10         20         30         40         50         60 
MPGPAVDAEK VPFRSAKEEI RAGVGVEGSE GGGGGGGRER PGARGHRQDI VWRNVFLMSL 

        70         80         90        100        110        120 
LHLAAVYSLV LIPKAQPLTL LWAYFCFLLT ALGVTAGAHR LWSHRSYKAK LPLRIFLAAA 

       130        140        150        160        170        180 
NSMAFQNDIF EWSRDHRVHH KYSETDADPH NARRGFFFSH IGWLFVRKHR DVIEKGRKLD 

       190        200        210        220        230        240 
VTDLLADPVV RFQRKYYKIT VVLMCFVVPT LVPWYIWGES LWNSYFLASI LRYTISLNVT 

       250        260        270        280        290        300 
WLVNSVAHMY GNRPYDKHIS PRQNPLVTLG AIGEGFHNYH HTFPFDYSAS EFGLNFNPTT 

       310        320        330 
WFIDFMCWLG LATDRKRATK QMIEARKART GDGSA 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of a novel bovine stearoyl-CoA desaturase isoform with homology to human SCD5."
Lengi A.J., Corl B.A.
Lipids 42:499-508(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Hypothalamus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EF014951 mRNA. Translation: ABJ99757.1.
BC112711 mRNA. Translation: AAI12712.1.
RefSeqNP_001070413.1. NM_001076945.1.
UniGeneBt.13249.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000025820.

Proteomic databases

PRIDEQ2KIA4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000025820; ENSBTAP00000025820; ENSBTAG00000022449.
GeneID617419.
KEGGbta:617419.

Organism-specific databases

CTD79966.

Phylogenomic databases

eggNOGCOG1398.
GeneTreeENSGT00530000063158.
HOGENOMHOG000270352.
HOVERGENHBG003367.
InParanoidQ2KIA4.
KOK00507.
OMAAAYFCFL.
OrthoDBEOG7ZPNKS.
TreeFamTF313251.

Family and domain databases

InterProIPR005804. Fatty_acid_desaturase-1.
IPR001522. Fatty_acid_desaturase-1_C.
IPR015876. Fatty_acid_desaturase-1_core.
[Graphical view]
PfamPF00487. FA_desaturase. 1 hit.
[Graphical view]
PRINTSPR00075. FACDDSATRASE.
PROSITEPS00476. FATTY_ACID_DESATUR_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20900654.

Entry information

Entry nameSCD5_BOVIN
AccessionPrimary (citable) accession number: Q2KIA4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 7, 2006
Last modified: February 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families