Reviewed, UniProtKB/Swiss-Prot Q2KIA4 (SCD5_BOVIN)

Names and origin

Protein names

Recommended name:
    Stearoyl-CoA desaturase 5
    EC=1.14.19.1
Alternative name(s):
    Acyl-CoA-desaturase 4
    Stearoyl-CoA 9-desaturase

Gene names

Name:

SCD5

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Fatty acid delta(9)-desaturase that introduces a double bond in fatty acyl-coenzyme A at the delta 9 position By similarity.
Catalytic activity	Stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O.
Cofactor	Iron By similarity.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.
Tissue specificity	Detected in brain. Ref.1
Domain	The histidine box domains may contain the active site and/or be involved in metal ion binding By similarity.
Sequence similarities	Belongs to the fatty acid desaturase family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane
Ligand	Iron Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW stearoyl-CoA 9-desaturase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 335	335	Stearoyl-CoA desaturase 5		PRO_0000312652
Regions
	Transmembrane	55 – 75	21	Potential
	Transmembrane	78 – 98	21	Potential
	Transmembrane	199 – 219	21	Potential
	Transmembrane	228 – 247	20	Potential
	Motif	99 – 104	6	Histidine box-1 By similarity
	Motif	136 – 140	5	Histidine box-2 By similarity
	Motif	277 – 281	5	Histidine box-3 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2KIA4-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 32F8B2C60533AB31	FASTA	335	38,215
	10 20 30 40 50 60 MPGPAVDAEK VPFRSAKEEI RAGVGVEGSE GGGGGGGRER PGARGHRQDI VWRNVFLMSL 70 80 90 100 110 120 LHLAAVYSLV LIPKAQPLTL LWAYFCFLLT ALGVTAGAHR LWSHRSYKAK LPLRIFLAAA 130 140 150 160 170 180 NSMAFQNDIF EWSRDHRVHH KYSETDADPH NARRGFFFSH IGWLFVRKHR DVIEKGRKLD 190 200 210 220 230 240 VTDLLADPVV RFQRKYYKIT VVLMCFVVPT LVPWYIWGES LWNSYFLASI LRYTISLNVT 250 260 270 280 290 300 WLVNSVAHMY GNRPYDKHIS PRQNPLVTLG AIGEGFHNYH HTFPFDYSAS EFGLNFNPTT 310 320 330 WFIDFMCWLG LATDRKRATK QMIEARKART GDGSA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of a novel bovine stearoyl-CoA desaturase isoform with homology to human SCD5." Lengi A.J., Corl B.A. Lipids 42:499-508(2007) [PubMed: 17468887] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Hypothalamus.

Cross-references

Sequence databases
EMBLGenBankDDBJ	EF014951 mRNA. Translation: ABJ99757.1. BC112711 mRNA. Translation: AAI12712.1.
IPI	IPI00716739.
RefSeq	NP_001070413.1.
UniGene	Bt.13249
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000022449. Bos taurus. [Contig view]
GeneID	617419.
KEGG	bta:617419.
Phylogenomic databases
HOVERGEN	Q2KIA4.
OMA	Q2KIA4. CFFISAL.
Enzyme and pathway databases
BRENDA	1.14.19.1. 251.
Family and domain databases
InterPro	IPR005804. Fatty_acid_desaturase-1. IPR001522. Fatty_acid_desaturase-1_C. IPR015876. Fatty_acid_desaturase-1_core. [Graphical view]
Pfam	PF00487. FA_desaturase. 1 hit. [Graphical view]
PRINTS	PR00075. FACDDSATRASE.
ProDom	PD002221. Desaturase. 1 hit. PD001081. FA_desat_sub. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00476. FATTY_ACID_DESATUR_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SCD5_BOVIN

Accession

Primary (citable) accession number: Q2KIA4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	March 7, 2006
Last modified:	June 16, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)