ID   SYHC_BOVIN              Reviewed;         509 AA.
AC   Q2KI84;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   16-JUN-2009, entry version 27.
DE   RecName: Full=Histidyl-tRNA synthetase, cytoplasmic;
DE            EC=6.1.1.21;
DE   AltName: Full=Histidine--tRNA ligase;
DE            Short=HisRS;
GN   Name=HARS;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + L-histidine + tRNA(His) = AMP +
CC       diphosphate + L-histidyl-tRNA(His).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase
CC       family.
CC   -!- SIMILARITY: Contains 1 WHEP-TRS domain.
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DR   EMBL; BC112731; AAI12732.1; -; mRNA.
DR   IPI; IPI00686511; -.
DR   RefSeq; NP_001039531.1; -.
DR   UniGene; Bt.49179; -.
DR   SMR; Q2KI84; 1-60.
DR   Ensembl; ENSBTAG00000018847; Bos taurus.
DR   GeneID; 510937; -.
DR   KEGG; bta:510937; -.
DR   HOVERGEN; Q2KI84; -.
DR   BRENDA; 6.1.1.21; 251.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004821; F:histidine-tRNA ligase activity; IEA:EC.
DR   GO; GO:0006427; P:histidyl-tRNA aminoacylation; IEA:InterPro.
DR   InterPro; IPR002314; aa-tRNA-synt_IIb_cons-reg.
DR   InterPro; IPR006195; aa-tRNA-synth_II_cons-reg.
DR   InterPro; IPR004154; Anticodon_bd.
DR   InterPro; IPR015807; His-tRNA-synth_IIa_sub.
DR   InterPro; IPR004516; His-tRNA_synth_IIA.
DR   InterPro; IPR000738; WHEP-TRS.
DR   Gene3D; G3DSA:3.40.50.800; Anticodon_bd; 1.
DR   PANTHER; PTHR11476; His-tRNA_synth; 1.
DR   Pfam; PF03129; HGTP_anticodon; 1.
DR   Pfam; PF00587; tRNA-synt_2b; 1.
DR   Pfam; PF00458; WHEP-TRS; 1.
DR   PIRSF; PIRSF001549; His-tRNA_synth; 1.
DR   TIGRFAMs; TIGR00442; hisS; 1.
DR   PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
DR   PROSITE; PS00762; WHEP_TRS_1; 1.
DR   PROSITE; PS51185; WHEP_TRS_2; 1.
PE   2: Evidence at transcript level;
KW   Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
KW   Nucleotide-binding; Protein biosynthesis.
FT   CHAIN         1    509       Histidyl-tRNA synthetase, cytoplasmic.
FT                                /FTId=PRO_0000245021.
FT   DOMAIN        3     59       WHEP-TRS.
SQ   SEQUENCE   509 AA;  57285 MW;  54A2CAFD638D4358 CRC64;
     MADRAALEDL VRVQGERVRG LKQQKASAEQ IEEEVAKLLK LKAQLGPDEG KPKFVLKTPK
     GTRDYSPRQM AVREKVFDVI ISCFKRHGAE VIDTPVFELK ETLTGKYGED SKLIYDLKDQ
     GGELLSLRYD LTVPFARYLA MNKLTNIKRY HIAKVYRRDN PAMTRGRYRE FYQCDFDIAG
     QFDPMLPDAE CLKIMCEILS SLQIGDFLVK VNDRRILDGM FAICGVPDSK FRTICSSVDK
     LDKVSWEEVK NEMVGEKGLA PEVADRIGDY VQQHGGVSLV EQLLQDPKLS QNKQALEGLG
     DLKLLFEYLT LFGIADKISF DLSLARGLDY YTGVIYEAVL LQPPARAGEE PLGVGSVAAG
     GRYDGLVGMF DPKGRKVPCV GLSIGVERIF SIVEQRLEAL EEKVRTTETQ VLVASAQKKL
     LEERLKLISE LWDAGIKAEL LYKKNPKLLN QLQYCEETGI PLVAIIGEQE LKDGVIKLRS
     VASREEVDVR REDLVEEIKR RTSQPLCIC
//