Reviewed, UniProtKB/Swiss-Prot Q2KI84 (SYHC_BOVIN)

Names and origin

Protein names

Recommended name:
    Histidyl-tRNA synthetase, cytoplasmic
    EC=6.1.1.21
Alternative name(s):
    Histidine--tRNA ligase
      Short name=HisRS

Gene names

Name:

HARS

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	509 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family. Contains 1 WHEP-TRS domain.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Gene Ontology (GO)
Biological process	histidyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW histidine-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 509	509	Histidyl-tRNA synthetase, cytoplasmic		PRO_0000245021
Regions
	Domain	3 – 59	57	WHEP-TRS

Sequences

	Sequence		Length	Mass (Da)
	Q2KI84-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 54A2CAFD638D4358	FASTA	509	57,285
	10 20 30 40 50 60 MADRAALEDL VRVQGERVRG LKQQKASAEQ IEEEVAKLLK LKAQLGPDEG KPKFVLKTPK 70 80 90 100 110 120 GTRDYSPRQM AVREKVFDVI ISCFKRHGAE VIDTPVFELK ETLTGKYGED SKLIYDLKDQ 130 140 150 160 170 180 GGELLSLRYD LTVPFARYLA MNKLTNIKRY HIAKVYRRDN PAMTRGRYRE FYQCDFDIAG 190 200 210 220 230 240 QFDPMLPDAE CLKIMCEILS SLQIGDFLVK VNDRRILDGM FAICGVPDSK FRTICSSVDK 250 260 270 280 290 300 LDKVSWEEVK NEMVGEKGLA PEVADRIGDY VQQHGGVSLV EQLLQDPKLS QNKQALEGLG 310 320 330 340 350 360 DLKLLFEYLT LFGIADKISF DLSLARGLDY YTGVIYEAVL LQPPARAGEE PLGVGSVAAG 370 380 390 400 410 420 GRYDGLVGMF DPKGRKVPCV GLSIGVERIF SIVEQRLEAL EEKVRTTETQ VLVASAQKKL 430 440 450 460 470 480 LEERLKLISE LWDAGIKAEL LYKKNPKLLN QLQYCEETGI PLVAIIGEQE LKDGVIKLRS 490 500 VASREEVDVR REDLVEEIKR RTSQPLCIC

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Hypothalamus.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC112731 mRNA. Translation: AAI12732.1.
IPI	IPI00686511.
RefSeq	NP_001039531.1.
UniGene	Bt.49179
3D structure databases
SMR	Q2KI84. Positions 1-60.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000018847. Bos taurus. [Contig view]
GeneID	510937.
KEGG	bta:510937.
Phylogenomic databases
HOVERGEN	Q2KI84.
Enzyme and pathway databases
BRENDA	6.1.1.21. 251.
Family and domain databases
InterPro	IPR002314. aa-tRNA-synt_IIb_cons-reg. IPR006195. aa-tRNA-synth_II_cons-reg. IPR004154. Anticodon_bd. IPR015807. His-tRNA-synth_IIa_sub. IPR004516. His-tRNA_synth_IIA. IPR000738. WHEP-TRS. [Graphical view]
Gene3D	G3DSA:3.40.50.800. Anticodon_bd. 1 hit.
PANTHER	PTHR11476. His-tRNA_synth. 1 hit.
Pfam	PF03129. HGTP_anticodon. 1 hit. PF00587. tRNA-synt_2b. 1 hit. PF00458. WHEP-TRS. 1 hit. [Graphical view]
PIRSF	PIRSF001549. His-tRNA_synth. 1 hit.
TIGRFAMs	TIGR00442. hisS. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. PS00762. WHEP_TRS_1. 1 hit. PS51185. WHEP_TRS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYHC_BOVIN

Accession

Primary (citable) accession number: Q2KI84

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	March 7, 2006
Last modified:	June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)