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Protein

Tumor necrosis factor receptor type 1-associated DEATH domain protein

Gene

TRADD

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B (By similarity). The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiR-BTA-3371378. Regulation by c-FLIP.
R-BTA-5213460. RIPK1-mediated regulated necrosis.
R-BTA-5218900. CASP8 activity is inhibited.
R-BTA-5357786. TNFR1-induced proapoptotic signaling.
R-BTA-5357905. Regulation of TNFR1 signaling.
R-BTA-5357956. TNFR1-induced NFkappaB signaling pathway.
R-BTA-69416. Dimerization of procaspase-8.
R-BTA-75893. TNF signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor type 1-associated DEATH domain protein
Short name:
TNFR1-associated DEATH domain protein
Alternative name(s):
TNFRSF1A-associated via death domain
Gene namesi
Name:TRADDImported
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Tumor necrosis factor receptor type 1-associated DEATH domain proteinPRO_0000291658Add
BLAST

Proteomic databases

PaxDbiQ2KI74.

Expressioni

Gene expression databases

BgeeiENSBTAG00000012642.

Interactioni

Subunit structurei

Heterodimer with TNFRSF1A/TNFR1. Interacts with DAB2IP, FADD, HIPK2, KRT14, KRT16, KRT17, KRT18, RIPK1, SQSTM1, TRAF1, TRAF2 and TRPC4AP. Interacts with TRIP12 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016776.

Structurei

3D structure databases

ProteinModelPortaliQ2KI74.
SMRiQ2KI74. Positions 1-168.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini215 – 30591DeathPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni222 – 28968Interaction with KRT14 and KRT18By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi147 – 16317Nuclear export signalBy similarityAdd
BLAST
Motifi231 – 24414Nuclear localization signalBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi193 – 1986Poly-ProSequence analysis

Domaini

Requires the intact death domain to associate with TNFRSF1A/TNFR1.By similarity

Sequence similaritiesi

Contains 1 death domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IF81. Eukaryota.
ENOG4111IRA. LUCA.
GeneTreeiENSGT00390000002016.
HOGENOMiHOG000059664.
HOVERGENiHBG054083.
InParanoidiQ2KI74.
KOiK03171.
OMAiLRFCGRQ.
OrthoDBiEOG091G0DXR.
TreeFamiTF331882.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.30.70.680. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR009095. TRADD_N.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF09034. TRADD_N. 1 hit.
[Graphical view]
ProDomiPD182470. TRADD_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00005. DEATH. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF55044. SSF55044. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2KI74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGPNGLEE WVGSAYLFVE SSLDKVVLSD AYAHQQQKVA MYGALQTALA
60 70 80 90 100
ESGGSPDVLQ MLKIHRSDPQ LIVQLRFSGR QACSRFLRAY REGALRATLQ
110 120 130 140 150
GCLARALALN SVPLQLELRA GAEQLDALLT NEERCLNCIC AQKPDRLRDE
160 170 180 190 200
ELTELENALR NLTCGSAGGQ GSDVQGTPAP LQSLAPSPPE EKPPPPQPGQ
210 220 230 240 250
TFLFQGQPIV NRPLNLQDQQ KFARSVGLKW RKVGRSLQRS CRALRDPALD
260 270 280 290 300
SLAYEYERDG LYEQAFQLLR RFVQAEGRRA TLQRLVEALE ENELTSLAED
310
LLGLANPDGS LA
Length:312
Mass (Da):34,292
Last modified:March 7, 2006 - v1
Checksum:iBFB1F26AD5D9DCE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112743 mRNA. Translation: AAI12744.1.
RefSeqiNP_001039361.1. NM_001045896.2.
XP_010812732.1. XM_010814430.2.
UniGeneiBt.15875.

Genome annotation databases

EnsembliENSBTAT00000016776; ENSBTAP00000016776; ENSBTAG00000012642.
GeneIDi504707.
KEGGibta:504707.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112743 mRNA. Translation: AAI12744.1.
RefSeqiNP_001039361.1. NM_001045896.2.
XP_010812732.1. XM_010814430.2.
UniGeneiBt.15875.

3D structure databases

ProteinModelPortaliQ2KI74.
SMRiQ2KI74. Positions 1-168.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016776.

Proteomic databases

PaxDbiQ2KI74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000016776; ENSBTAP00000016776; ENSBTAG00000012642.
GeneIDi504707.
KEGGibta:504707.

Organism-specific databases

CTDi8717.

Phylogenomic databases

eggNOGiENOG410IF81. Eukaryota.
ENOG4111IRA. LUCA.
GeneTreeiENSGT00390000002016.
HOGENOMiHOG000059664.
HOVERGENiHBG054083.
InParanoidiQ2KI74.
KOiK03171.
OMAiLRFCGRQ.
OrthoDBiEOG091G0DXR.
TreeFamiTF331882.

Enzyme and pathway databases

ReactomeiR-BTA-3371378. Regulation by c-FLIP.
R-BTA-5213460. RIPK1-mediated regulated necrosis.
R-BTA-5218900. CASP8 activity is inhibited.
R-BTA-5357786. TNFR1-induced proapoptotic signaling.
R-BTA-5357905. Regulation of TNFR1 signaling.
R-BTA-5357956. TNFR1-induced NFkappaB signaling pathway.
R-BTA-69416. Dimerization of procaspase-8.
R-BTA-75893. TNF signaling.

Gene expression databases

BgeeiENSBTAG00000012642.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.30.70.680. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR009095. TRADD_N.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF09034. TRADD_N. 1 hit.
[Graphical view]
ProDomiPD182470. TRADD_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00005. DEATH. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF55044. SSF55044. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRADD_BOVIN
AccessioniPrimary (citable) accession number: Q2KI74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 7, 2006
Last modified: September 7, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.