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Protein

Tumor necrosis factor receptor type 1-associated DEATH domain protein

Gene

TRADD

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B (By similarity). The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-BTA-3371378. Regulation by c-FLIP.
R-BTA-5213460. RIPK1-mediated regulated necrosis.
R-BTA-5218900. CASP8 activity is inhibited.
R-BTA-5357786. TNFR1-induced proapoptotic signaling.
R-BTA-5357905. Regulation of TNFR1 signaling.
R-BTA-5357956. TNFR1-induced NFkappaB signaling pathway.
R-BTA-69416. Dimerization of procaspase-8.
R-BTA-75893. TNF signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor type 1-associated DEATH domain protein
Short name:
TNFR1-associated DEATH domain protein
Alternative name(s):
TNFRSF1A-associated via death domain
Gene namesi
Name:TRADDImported
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002916581 – 312Tumor necrosis factor receptor type 1-associated DEATH domain proteinAdd BLAST312

Proteomic databases

PaxDbiQ2KI74.
PRIDEiQ2KI74.

Expressioni

Gene expression databases

BgeeiENSBTAG00000012642.

Interactioni

Subunit structurei

Stimulation of TNF-alpha receptor TNFRSF1A leads to the formation of two distinct signaling complexes. Plasma membrane-bound complex I is composed of TNFRSF1A, TRADD, RIPK1, TRAF2 and BIRC2/c-IAP1 or BIRC3 which interacts with CHUCK/IKK-alpha, IKBKB/IKK-beta and IKBKG/IKK-gamma promoting cell survival. Subsequently, TRADD, RIPK1 and TRAF2 dissociate from TNFRSF1A and form cytoplasmic complex II with FADD and caspase CASP8 promoting cell apoptosis. Within complex I, interacts with TNFRSF1A/TNFR1, TRAF2 and kinase RIPK1. Within complex I, interacts with TRPC4AP; the interaction promotes NF-kappa B activation. UXT1 associates with complex I; the interaction prevents the formation of complex II. Within complex I Interacts with scaffold protein DAB2IP. Interacts with autophagy receptor SQSTM1. Interacts with E3 ligase TRIP12. Interacts with kinase HIPK2. Interacts with keratin KRT14. Interacts with keratin KRT18. Interacts with KRT16 and KRT17.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016776.

Structurei

3D structure databases

ProteinModelPortaliQ2KI74.
SMRiQ2KI74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini215 – 305DeathPROSITE-ProRule annotationAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni222 – 289Interaction with KRT14 and KRT18By similarityAdd BLAST68

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi147 – 163Nuclear export signalBy similarityAdd BLAST17
Motifi231 – 244Nuclear localization signalBy similarityAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi193 – 198Poly-ProSequence analysis6

Domaini

Requires the intact death domain to associate with TNFRSF1A/TNFR1.By similarity

Phylogenomic databases

eggNOGiENOG410IF81. Eukaryota.
ENOG4111IRA. LUCA.
GeneTreeiENSGT00390000002016.
HOGENOMiHOG000059664.
HOVERGENiHBG054083.
InParanoidiQ2KI74.
KOiK03171.
OMAiFCGRQPC.
OrthoDBiEOG091G0DXR.
TreeFamiTF331882.

Family and domain databases

Gene3Di3.30.70.680. 1 hit.
InterProiView protein in InterPro
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR035712. TRADD.
IPR009095. TRADD_N.
PANTHERiPTHR14913. PTHR14913. 1 hit.
PfamiView protein in Pfam
PF00531. Death. 1 hit.
PF09034. TRADD_N. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD182470. TRADD_N. 1 hit.
SMARTiView protein in SMART
SM00005. DEATH. 1 hit.
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF55044. SSF55044. 1 hit.
PROSITEiView protein in PROSITE
PS50017. DEATH_DOMAIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2KI74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGPNGLEE WVGSAYLFVE SSLDKVVLSD AYAHQQQKVA MYGALQTALA
60 70 80 90 100
ESGGSPDVLQ MLKIHRSDPQ LIVQLRFSGR QACSRFLRAY REGALRATLQ
110 120 130 140 150
GCLARALALN SVPLQLELRA GAEQLDALLT NEERCLNCIC AQKPDRLRDE
160 170 180 190 200
ELTELENALR NLTCGSAGGQ GSDVQGTPAP LQSLAPSPPE EKPPPPQPGQ
210 220 230 240 250
TFLFQGQPIV NRPLNLQDQQ KFARSVGLKW RKVGRSLQRS CRALRDPALD
260 270 280 290 300
SLAYEYERDG LYEQAFQLLR RFVQAEGRRA TLQRLVEALE ENELTSLAED
310
LLGLANPDGS LA
Length:312
Mass (Da):34,292
Last modified:March 7, 2006 - v1
Checksum:iBFB1F26AD5D9DCE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112743 mRNA. Translation: AAI12744.1.
RefSeqiNP_001039361.1. NM_001045896.2.
XP_010812732.1. XM_010814430.2.
UniGeneiBt.15875.

Genome annotation databases

EnsembliENSBTAT00000016776; ENSBTAP00000016776; ENSBTAG00000012642.
GeneIDi504707.
KEGGibta:504707.

Similar proteinsi

Entry informationi

Entry nameiTRADD_BOVIN
AccessioniPrimary (citable) accession number: Q2KI74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 7, 2006
Last modified: September 27, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome