Reviewed, UniProtKB/Swiss-Prot Q2KI06 (PHOP2_BOVIN)

Names and origin

Protein names

Recommended name:
    Pyridoxal phosphate phosphatase PHOSPHO2
    EC=3.1.3.74

Gene names

Name:

PHOSPHO2

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	241 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Phosphatase that has high activity toward pyridoxal 5'-phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate By similarity.
Catalytic activity	Pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

Ontologies

Keywords
Ligand	Magnesium Metal-binding Pyridoxal phosphate
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW pyridoxal phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 241	241	Pyridoxal phosphate phosphatase PHOSPHO2		PRO_0000254017
Sites
	Active site	8	1	Nucleophile By similarity
	Active site	10	1	Proton donor By similarity
	Metal binding	8	1	Magnesium By similarity
	Metal binding	10	1	Magnesium By similarity
	Metal binding	179	1	Magnesium By similarity
	Binding site	19	1	Substrate By similarity
	Binding site	99	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2KI06-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 86EF01C1A6A54325	FASTA	241	27,751
	10 20 30 40 50 60 MKILLVFDFD NTIIDDNSDT WIVQCAPEKK LPLELKDSYK KGFWTEFMGR VFKYLGDEGV 70 80 90 100 110 120 REDEMKRAMI SMPFTPGMVE LLNFIRKNKN KFDCIIISDS NSVFIDWVLE ATNFHDVFDK 130 140 150 160 170 180 VFTNPAAFDS NGHLTVEKHH THSCTRCPQN LCKNVVLVEF VGEQLQQGVN YTRIVYIGDG 190 200 210 220 230 240 GNDVCPVTFL KKNDIAMPRK GYALQKTLYR MCQNLEPMES SVVSWSSGVE IISYLQFLIK E

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Heart ventricle.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC112815 mRNA. Translation: AAI12816.1.
IPI	IPI00704487.
RefSeq	NP_001039430.1.
UniGene	Bt.52539
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000001092. Bos taurus. [Contig view]
GeneID	507308.
KEGG	bta:507308.
Phylogenomic databases
HOVERGEN	Q2KI06.
OMA	Q2KI06. NDVAMPR.
Enzyme and pathway databases
BRENDA	3.1.3.74. 251.
Family and domain databases
InterPro	IPR006383. HAD-SF_hydro_IB_PSP-like. IPR006384. PyrdxlP_Pase-rel. IPR016965. PyrdxlP_Pase_PHOSPHO2. [Graphical view]
Pfam	PF06888. Put_Phosphatase. 1 hit. [Graphical view]
PIRSF	PIRSF031051. PyrdxlP_Pase_PHOSPHO2. 1 hit.
TIGRFAMs	TIGR01489. DKMTPPase-SF. 1 hit. TIGR01488. HAD-SF-IB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PHOP2_BOVIN

Accession

Primary (citable) accession number: Q2KI06

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	March 7, 2006
Last modified:	June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)