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Protein

Pyridoxal phosphate phosphatase PHOSPHO2

Gene

PHOSPHO2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Phosphatase that has high activity toward pyridoxal 5'-phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate (By similarity).By similarity

Catalytic activityi

Pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei8NucleophileBy similarity1
Metal bindingi8MagnesiumBy similarity1
Active sitei10Proton donorBy similarity1
Metal bindingi10MagnesiumBy similarity1
Binding sitei19SubstrateBy similarity1
Binding sitei99SubstrateBy similarity1
Metal bindingi179MagnesiumBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding, Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyridoxal phosphate phosphatase PHOSPHO2 (EC:3.1.3.74)
Gene namesi
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Organism-specific databases

VGNCiVGNC:32843 PHOSPHO2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002540171 – 241Pyridoxal phosphate phosphatase PHOSPHO2Add BLAST241

Proteomic databases

PaxDbiQ2KI06
PRIDEiQ2KI06

Expressioni

Gene expression databases

BgeeiENSBTAG00000001092

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001446

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3120 Eukaryota
ENOG4111NAQ LUCA
GeneTreeiENSGT00390000007741
HOGENOMiHOG000231038
HOVERGENiHBG080058
InParanoidiQ2KI06
KOiK13248
OMAiSPNMCKG
OrthoDBiEOG091G0GZ1
TreeFamiTF300112

Family and domain databases

Gene3Di3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR016965 Pase_PHOSPHO-typ
IPR006384 PyrdxlP_Pase-rel
PANTHERiPTHR20889 PTHR20889, 1 hit
PfamiView protein in Pfam
PF06888 Put_Phosphatase, 1 hit
PIRSFiPIRSF031051 PyrdxlP_Pase_PHOSPHO2, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR01489 DKMTPPase-SF, 1 hit

Sequencei

Sequence statusi: Complete.

Q2KI06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILLVFDFD NTIIDDNSDT WIVQCAPEKK LPLELKDSYK KGFWTEFMGR
60 70 80 90 100
VFKYLGDEGV REDEMKRAMI SMPFTPGMVE LLNFIRKNKN KFDCIIISDS
110 120 130 140 150
NSVFIDWVLE ATNFHDVFDK VFTNPAAFDS NGHLTVEKHH THSCTRCPQN
160 170 180 190 200
LCKNVVLVEF VGEQLQQGVN YTRIVYIGDG GNDVCPVTFL KKNDIAMPRK
210 220 230 240
GYALQKTLYR MCQNLEPMES SVVSWSSGVE IISYLQFLIK E
Length:241
Mass (Da):27,751
Last modified:March 7, 2006 - v1
Checksum:i86EF01C1A6A54325
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112815 mRNA Translation: AAI12816.1
RefSeqiNP_001039430.1, NM_001045965.2
XP_010800188.1, XM_010801886.2
UniGeneiBt.36836

Genome annotation databases

EnsembliENSBTAT00000001446; ENSBTAP00000001446; ENSBTAG00000001092
GeneIDi507308
KEGGibta:507308

Similar proteinsi

Entry informationi

Entry nameiPHOP2_BOVIN
AccessioniPrimary (citable) accession number: Q2KI06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 7, 2006
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health