Q2KI06 (PHOP2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyridoxal phosphate phosphatase PHOSPHO2
EC=3.1.3.74

Gene names

Name:

PHOSPHO2

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	241 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Phosphatase that has high activity toward pyridoxal 5'-phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate By similarity.
Catalytic activity	Pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

Ontologies

Keywords
Ligand	Magnesium Metal-binding Pyridoxal phosphate
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW pyridoxal phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 241	241	Pyridoxal phosphate phosphatase PHOSPHO2		PRO_0000254017
Sites
	Active site	8	1	Nucleophile By similarity
	Active site	10	1	Proton donor By similarity
	Metal binding	8	1	Magnesium By similarity
	Metal binding	10	1	Magnesium By similarity
	Metal binding	179	1	Magnesium By similarity
	Binding site	19	1	Substrate By similarity
	Binding site	99	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2KI06 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 86EF01C1A6A54325	FASTA	241	27,751
	10 20 30 40 50 60 MKILLVFDFD NTIIDDNSDT WIVQCAPEKK LPLELKDSYK KGFWTEFMGR VFKYLGDEGV 70 80 90 100 110 120 REDEMKRAMI SMPFTPGMVE LLNFIRKNKN KFDCIIISDS NSVFIDWVLE ATNFHDVFDK 130 140 150 160 170 180 VFTNPAAFDS NGHLTVEKHH THSCTRCPQN LCKNVVLVEF VGEQLQQGVN YTRIVYIGDG 190 200 210 220 230 240 GNDVCPVTFL KKNDIAMPRK GYALQKTLYR MCQNLEPMES SVVSWSSGVE IISYLQFLIK E

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Heart ventricle.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC112815 mRNA. Translation: AAI12816.1.
IPI	IPI00704487.
RefSeq	NP_001039430.1. NM_001045965.1.
UniGene	Bt.52539.
3D structure databases
ProteinModelPortal	Q2KI06.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2KI06.
Proteomic databases
PRIDE	Q2KI06.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000001446; ENSBTAP00000001446; ENSBTAG00000001092.
GeneID	507308.
KEGG	bta:507308.
Organism-specific databases
CTD	493911.
Phylogenomic databases
eggNOG	maNOG08553.
GeneTree	ENSGT00390000007741.
HOVERGEN	HBG080058.
InParanoid	Q2KI06.
OMA	DWVLEAT.
OrthoDB	EOG4S4PH0.
Family and domain databases
InterPro	IPR023214. HAD-like_dom. IPR006383. HAD-SF_hydro_IB_PSP-like. IPR016965. Pase_PHOSPHO-typ. IPR006384. PyrdxlP_Pase-rel. [Graphical view]
Gene3D	G3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
KO	K13248.
Pfam	PF06888. Put_Phosphatase. 1 hit. [Graphical view]
PIRSF	PIRSF031051. PyrdxlP_Pase_PHOSPHO2. 1 hit.
SUPFAM	SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01489. DKMTPPase-SF. 1 hit. TIGR01488. HAD-SF-IB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PHOP2_BOVIN

Accession

Primary (citable) accession number: Q2KI06

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	March 7, 2006
Last modified:	December 14, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program