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Protein

Pyridoxal phosphate phosphatase PHOSPHO2

Gene

PHOSPHO2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Phosphatase that has high activity toward pyridoxal 5'-phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate (By similarity).By similarity

Catalytic activityi

Pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei8 – 81NucleophileBy similarity
Metal bindingi8 – 81MagnesiumBy similarity
Active sitei10 – 101Proton donorBy similarity
Metal bindingi10 – 101MagnesiumBy similarity
Binding sitei19 – 191SubstrateBy similarity
Binding sitei99 – 991SubstrateBy similarity
Metal bindingi179 – 1791MagnesiumBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding, Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyridoxal phosphate phosphatase PHOSPHO2 (EC:3.1.3.74)
Gene namesi
Name:PHOSPHO2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241Pyridoxal phosphate phosphatase PHOSPHO2PRO_0000254017Add
BLAST

Proteomic databases

PaxDbiQ2KI06.
PRIDEiQ2KI06.

Expressioni

Gene expression databases

BgeeiENSBTAG00000001092.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001446.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3120. Eukaryota.
ENOG4111NAQ. LUCA.
GeneTreeiENSGT00390000007741.
HOGENOMiHOG000231038.
HOVERGENiHBG080058.
InParanoidiQ2KI06.
KOiK13248.
OMAiASQFECK.
OrthoDBiEOG091G0GZ1.
TreeFamiTF300112.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006383. HAD-SF_hydro_IB_PSP-like.
IPR016965. Pase_PHOSPHO-typ.
IPR006384. PyrdxlP_Pase-rel.
[Graphical view]
PfamiPF06888. Put_Phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF031051. PyrdxlP_Pase_PHOSPHO2. 1 hit.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01489. DKMTPPase-SF. 1 hit.
TIGR01488. HAD-SF-IB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2KI06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILLVFDFD NTIIDDNSDT WIVQCAPEKK LPLELKDSYK KGFWTEFMGR
60 70 80 90 100
VFKYLGDEGV REDEMKRAMI SMPFTPGMVE LLNFIRKNKN KFDCIIISDS
110 120 130 140 150
NSVFIDWVLE ATNFHDVFDK VFTNPAAFDS NGHLTVEKHH THSCTRCPQN
160 170 180 190 200
LCKNVVLVEF VGEQLQQGVN YTRIVYIGDG GNDVCPVTFL KKNDIAMPRK
210 220 230 240
GYALQKTLYR MCQNLEPMES SVVSWSSGVE IISYLQFLIK E
Length:241
Mass (Da):27,751
Last modified:March 7, 2006 - v1
Checksum:i86EF01C1A6A54325
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112815 mRNA. Translation: AAI12816.1.
RefSeqiNP_001039430.1. NM_001045965.2.
XP_010800188.1. XM_010801886.2.
UniGeneiBt.36836.

Genome annotation databases

EnsembliENSBTAT00000001446; ENSBTAP00000001446; ENSBTAG00000001092.
GeneIDi507308.
KEGGibta:507308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112815 mRNA. Translation: AAI12816.1.
RefSeqiNP_001039430.1. NM_001045965.2.
XP_010800188.1. XM_010801886.2.
UniGeneiBt.36836.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001446.

Proteomic databases

PaxDbiQ2KI06.
PRIDEiQ2KI06.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000001446; ENSBTAP00000001446; ENSBTAG00000001092.
GeneIDi507308.
KEGGibta:507308.

Organism-specific databases

CTDi493911.

Phylogenomic databases

eggNOGiKOG3120. Eukaryota.
ENOG4111NAQ. LUCA.
GeneTreeiENSGT00390000007741.
HOGENOMiHOG000231038.
HOVERGENiHBG080058.
InParanoidiQ2KI06.
KOiK13248.
OMAiASQFECK.
OrthoDBiEOG091G0GZ1.
TreeFamiTF300112.

Gene expression databases

BgeeiENSBTAG00000001092.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006383. HAD-SF_hydro_IB_PSP-like.
IPR016965. Pase_PHOSPHO-typ.
IPR006384. PyrdxlP_Pase-rel.
[Graphical view]
PfamiPF06888. Put_Phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF031051. PyrdxlP_Pase_PHOSPHO2. 1 hit.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01489. DKMTPPase-SF. 1 hit.
TIGR01488. HAD-SF-IB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPHOP2_BOVIN
AccessioniPrimary (citable) accession number: Q2KI06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 7, 2006
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.