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Protein

Glutaryl-CoA dehydrogenase, mitochondrial

Gene

GCDH

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO2 in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor (By similarity).By similarity

Catalytic activityi

Glutaryl-CoA + electron-transfer flavoprotein = crotonyl-CoA + CO2 + reduced electron-transfer flavoprotein.

Cofactori

FADBy similarity

Pathwayi: lysine degradation

This protein is involved in the pathway lysine degradation, which is part of Amino-acid metabolism.
View all proteins of this organism that are known to be involved in the pathway lysine degradation and in Amino-acid metabolism.

Pathwayi: tryptophan metabolism

This protein is involved in the pathway tryptophan metabolism, which is part of Amino-acid metabolism.
View all proteins of this organism that are known to be involved in the pathway tryptophan metabolism and in Amino-acid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei186 – 1861FADBy similarity
Binding sitei186 – 1861Substrate; via carbonyl oxygenBy similarity
Binding sitei294 – 2941SubstrateBy similarity
Binding sitei319 – 3191FADBy similarity
Binding sitei330 – 3301FADBy similarity
Active sitei414 – 4141Proton acceptorBy similarity
Binding sitei415 – 4151Substrate; via amide nitrogenBy similarity
Binding sitei416 – 4161FADBy similarity
Binding sitei434 – 4341FAD; via carbonyl oxygenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi177 – 18610FADBy similarity
Nucleotide bindingi177 – 1804FADBy similarity
Nucleotide bindingi212 – 2143FADBy similarity
Nucleotide bindingi387 – 3915FADBy similarity
Nucleotide bindingi416 – 4183FADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-BTA-71064. Lysine catabolism.
UniPathwayiUPA00224.
UPA00225.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaryl-CoA dehydrogenase, mitochondrial (EC:1.3.8.6)
Short name:
GCD
Gene namesi
Name:GCDH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4444MitochondrionSequence analysisAdd
BLAST
Chaini45 – 438394Glutaryl-CoA dehydrogenase, mitochondrialPRO_0000281992Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei240 – 2401N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ2KHZ9.
PeptideAtlasiQ2KHZ9.
PRIDEiQ2KHZ9.

Expressioni

Gene expression databases

BgeeiENSBTAG00000016211.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000043333.

Structurei

3D structure databases

ProteinModelPortaliQ2KHZ9.
SMRiQ2KHZ9. Positions 47-436.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni138 – 1392Substrate bindingBy similarity
Regioni287 – 2948Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the acyl-CoA dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0138. Eukaryota.
COG1960. LUCA.
GeneTreeiENSGT00760000119007.
HOGENOMiHOG000131662.
HOVERGENiHBG001939.
InParanoidiQ2KHZ9.
KOiK00252.
OMAiRCEDGCI.
OrthoDBiEOG091G07GZ.
TreeFamiTF105051.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
InterProiIPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEiPS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KHZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRGVYAQL LNRGPGLRVF RSWSSATAQT EKGEKTQSRS AKPSRPEFDW
60 70 80 90 100
RDPLLLEEQL TADEILIRDT FRTYCQERLM PRILLANRNE VFHREIISEM
110 120 130 140 150
GELGMLGPTI QGYSCAGVSS VAYGLLAREL ERVDSGYRSA MSVQSSLVMY
160 170 180 190 200
PIYAYGSEEQ KQKYLPRLAK GELLGCFGLT EPNHGSDPSG METRARHNPS
210 220 230 240 250
SRSYILSGSK TWITNSPVAD LLIVWARCED SCIRGFLLEK GMRGLSTPRI
260 270 280 290 300
EGKFSLRASS TGMIIMDDVE VPEENVLPGV SGLAGPFGCL NNARYGITWG
310 320 330 340 350
VLGAAEFCLH TARQYTLDRI QFGVPLAKNQ LIQKKLADML TEITLGLHAC
360 370 380 390 400
LQLGRLKDQD KAAPEMVSLL KRNNCGKALD IARQARDMLG GNGISDEYHV
410 420 430
IRHVMNLESV NTYEGTHDIH ALILGRAITG IQAFVAGK
Length:438
Mass (Da):48,472
Last modified:March 7, 2006 - v1
Checksum:iC420C9901292CDEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112822 mRNA. Translation: AAI12823.1.
RefSeqiNP_001039404.1. NM_001045939.2.
UniGeneiBt.43227.

Genome annotation databases

EnsembliENSBTAT00000045996; ENSBTAP00000043333; ENSBTAG00000016211.
GeneIDi506310.
KEGGibta:506310.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112822 mRNA. Translation: AAI12823.1.
RefSeqiNP_001039404.1. NM_001045939.2.
UniGeneiBt.43227.

3D structure databases

ProteinModelPortaliQ2KHZ9.
SMRiQ2KHZ9. Positions 47-436.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000043333.

Proteomic databases

PaxDbiQ2KHZ9.
PeptideAtlasiQ2KHZ9.
PRIDEiQ2KHZ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000045996; ENSBTAP00000043333; ENSBTAG00000016211.
GeneIDi506310.
KEGGibta:506310.

Organism-specific databases

CTDi2639.

Phylogenomic databases

eggNOGiKOG0138. Eukaryota.
COG1960. LUCA.
GeneTreeiENSGT00760000119007.
HOGENOMiHOG000131662.
HOVERGENiHBG001939.
InParanoidiQ2KHZ9.
KOiK00252.
OMAiRCEDGCI.
OrthoDBiEOG091G07GZ.
TreeFamiTF105051.

Enzyme and pathway databases

UniPathwayiUPA00224.
UPA00225.
ReactomeiR-BTA-71064. Lysine catabolism.

Gene expression databases

BgeeiENSBTAG00000016211.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
InterProiIPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEiPS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGCDH_BOVIN
AccessioniPrimary (citable) accession number: Q2KHZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 7, 2006
Last modified: September 7, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.