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Protein

Ketimine reductase mu-crystallin

Gene

CRYM

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors (By similarity).By similarity

Catalytic activityi

Thiomorpholine 3-carboxylate + NAD(P)+ = 3,4-dehydro-thiomorpholine-3-carboxylate + NAD(P)H.

Cofactori

NAD+By similarity, NADP+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei168NADPBy similarity1
Binding sitei169NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi143 – 148NADPBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD, NADP

Enzyme and pathway databases

ReactomeiR-BTA-71064 Lysine catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Ketimine reductase mu-crystallin (EC:1.5.1.25)
Alternative name(s):
NADP-regulated thyroid-hormone-binding protein
Gene namesi
Name:CRYM
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Organism-specific databases

VGNCiVGNC:27745 CRYM

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003282611 – 313Ketimine reductase mu-crystallinAdd BLAST313

Proteomic databases

PaxDbiQ2KHX6
PRIDEiQ2KHX6

Expressioni

Gene expression databases

BgeeiENSBTAG00000009842

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012972

Structurei

3D structure databases

ProteinModelPortaliQ2KHX6
SMRiQ2KHX6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3007 Eukaryota
COG2423 LUCA
GeneTreeiENSGT00390000000237
HOGENOMiHOG000137263
HOVERGENiHBG005408
InParanoidiQ2KHX6
KOiK18258
OMAiHTHINAM
OrthoDBiEOG091G0NR8
TreeFamiTF105309

Family and domain databases

Gene3Di3.30.1780.10, 2 hits
InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR003462 ODC_Mu_crystall
IPR023401 ODC_N
PANTHERiPTHR13812 PTHR13812, 1 hit
PfamiView protein in Pfam
PF02423 OCD_Mu_crystall, 1 hit
PIRSFiPIRSF001439 CryM, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

Q2KHX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRPVFLSA ADVQDHLRSS SLLIAPLETA LANFSSGPDG GVVQPVRTVV
60 70 80 90 100
PVAKHRGFLG VMPAYSAAED ALTTKLVTFY EDHSATSTVP SHQATVLLFQ
110 120 130 140 150
PSNGSLLAVM DGNVITAKRT AAVSAIATKF LKPPNSEVLC ILGAGVQAYS
160 170 180 190 200
HYEVFTEQFF FKEVRIWNRT KENAEKFVNT VPGEVRICSS VQEAVTGADV
210 220 230 240 250
IITVTMATEP ILFGEWVKPG AHINAIGASR PDWRELDDEL MKQAVLYVDS
260 270 280 290 300
QEAALKESGD VLLSGAEIFA ELGEVVKGVK PAHCEKTTVF KSLGMAVEDM
310
VAAKLVYDSW SSGK
Length:314
Mass (Da):33,747
Last modified:March 7, 2006 - v1
Checksum:iD9EAE1F47B7CAE2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112846 mRNA Translation: AAI12847.1
RefSeqiNP_001039379.1, NM_001045914.2
UniGeneiBt.2913

Genome annotation databases

EnsembliENSBTAT00000012972; ENSBTAP00000012972; ENSBTAG00000009842
GeneIDi505167
KEGGibta:505167

Similar proteinsi

Entry informationi

Entry nameiCRYM_BOVIN
AccessioniPrimary (citable) accession number: Q2KHX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: March 7, 2006
Last modified: March 28, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health