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Protein

Ketimine reductase mu-crystallin

Gene

CRYM

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors (By similarity).By similarity

Catalytic activityi

Thiomorpholine 3-carboxylate + NAD(P)+ = 3,4-dehydro-thiomorpholine-3-carboxylate + NAD(P)H.

Cofactori

NAD+By similarity, NADP+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei168NADPBy similarity1
Binding sitei169NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi143 – 148NADPBy similarity6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

ReactomeiR-BTA-71064. Lysine catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Ketimine reductase mu-crystallin (EC:1.5.1.25)
Alternative name(s):
NADP-regulated thyroid-hormone-binding protein
Gene namesi
Name:CRYM
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003282611 – 313Ketimine reductase mu-crystallinAdd BLAST313

Proteomic databases

PaxDbiQ2KHX6.
PRIDEiQ2KHX6.

Expressioni

Gene expression databases

BgeeiENSBTAG00000009842.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012972.

Structurei

3D structure databases

ProteinModelPortaliQ2KHX6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3007. Eukaryota.
COG2423. LUCA.
GeneTreeiENSGT00390000000237.
HOGENOMiHOG000137263.
HOVERGENiHBG005408.
InParanoidiQ2KHX6.
KOiK18258.
OMAiQRNLVNM.
OrthoDBiEOG091G0NR8.
TreeFamiTF105309.

Family and domain databases

Gene3Di3.30.1780.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR003462. ODC_Mu_crystall.
IPR023401. ODC_N.
[Graphical view]
PfamiPF02423. OCD_Mu_crystall. 1 hit.
[Graphical view]
PIRSFiPIRSF001439. CryM. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2KHX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRPVFLSA ADVQDHLRSS SLLIAPLETA LANFSSGPDG GVVQPVRTVV
60 70 80 90 100
PVAKHRGFLG VMPAYSAAED ALTTKLVTFY EDHSATSTVP SHQATVLLFQ
110 120 130 140 150
PSNGSLLAVM DGNVITAKRT AAVSAIATKF LKPPNSEVLC ILGAGVQAYS
160 170 180 190 200
HYEVFTEQFF FKEVRIWNRT KENAEKFVNT VPGEVRICSS VQEAVTGADV
210 220 230 240 250
IITVTMATEP ILFGEWVKPG AHINAIGASR PDWRELDDEL MKQAVLYVDS
260 270 280 290 300
QEAALKESGD VLLSGAEIFA ELGEVVKGVK PAHCEKTTVF KSLGMAVEDM
310
VAAKLVYDSW SSGK
Length:314
Mass (Da):33,747
Last modified:March 7, 2006 - v1
Checksum:iD9EAE1F47B7CAE2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112846 mRNA. Translation: AAI12847.1.
RefSeqiNP_001039379.1. NM_001045914.2.
UniGeneiBt.2913.

Genome annotation databases

EnsembliENSBTAT00000012972; ENSBTAP00000012972; ENSBTAG00000009842.
GeneIDi505167.
KEGGibta:505167.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112846 mRNA. Translation: AAI12847.1.
RefSeqiNP_001039379.1. NM_001045914.2.
UniGeneiBt.2913.

3D structure databases

ProteinModelPortaliQ2KHX6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012972.

Proteomic databases

PaxDbiQ2KHX6.
PRIDEiQ2KHX6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000012972; ENSBTAP00000012972; ENSBTAG00000009842.
GeneIDi505167.
KEGGibta:505167.

Organism-specific databases

CTDi1428.

Phylogenomic databases

eggNOGiKOG3007. Eukaryota.
COG2423. LUCA.
GeneTreeiENSGT00390000000237.
HOGENOMiHOG000137263.
HOVERGENiHBG005408.
InParanoidiQ2KHX6.
KOiK18258.
OMAiQRNLVNM.
OrthoDBiEOG091G0NR8.
TreeFamiTF105309.

Enzyme and pathway databases

ReactomeiR-BTA-71064. Lysine catabolism.

Gene expression databases

BgeeiENSBTAG00000009842.

Family and domain databases

Gene3Di3.30.1780.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR003462. ODC_Mu_crystall.
IPR023401. ODC_N.
[Graphical view]
PfamiPF02423. OCD_Mu_crystall. 1 hit.
[Graphical view]
PIRSFiPIRSF001439. CryM. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCRYM_BOVIN
AccessioniPrimary (citable) accession number: Q2KHX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: March 7, 2006
Last modified: November 30, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.