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Q2KHW7 (RGS10_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Regulator of G-protein signaling 10

Short name=RGS10
Gene names
Name:RGS10
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length181 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)-alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein By similarity.

Sequence similarities

Contains 1 RGS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 181181Regulator of G-protein signaling 10
PRO_0000244459

Regions

Domain41 – 156116RGS

Amino acid modifications

Lipidation741S-palmitoyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2KHW7 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: F722EFB8EFFE9801

FASTA18121,195
        10         20         30         40         50         60 
MFNRAVSRLS RKRPPSDIHD SDGSSSSSHQ TPKSTAKWAS SLENLLEDPE GVKRFREFLK 

        70         80         90        100        110        120 
KEFSEENVLF WLACEDFKKT QDKKQMQEKA KEIYMTFLSS KASSQVNVEG QSRLNEKILE 

       130        140        150        160        170        180 
EPHPLMFQKL QDQIFNLMKY DSYSRFLKSD LFLKHKRTEE EDEESPDAQT AAKRASRIYN 


T 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Hypothalamus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC112856 mRNA. Translation: AAI12857.1.
RefSeqNP_001040005.1. NM_001046540.2.
UniGeneBt.31630.

3D structure databases

ProteinModelPortalQ2KHW7.
SMRQ2KHW7. Positions 33-172.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000003425.

Proteomic databases

PRIDEQ2KHW7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000003425; ENSBTAP00000003425; ENSBTAG00000002647.
GeneID614550.
KEGGbta:614550.

Organism-specific databases

CTD6001.

Phylogenomic databases

eggNOGNOG271158.
GeneTreeENSGT00700000104412.
HOGENOMHOG000233512.
HOVERGENHBG013233.
InParanoidQ2KHW7.
KOK16449.
OMAPKSTAKW.
OrthoDBEOG7XDBF0.
TreeFamTF315837.

Family and domain databases

Gene3D1.10.196.10. 1 hit.
InterProIPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamPF00615. RGS. 1 hit.
[Graphical view]
PRINTSPR01301. RGSPROTEIN.
SMARTSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMSSF48097. SSF48097. 1 hit.
PROSITEPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20899157.

Entry information

Entry nameRGS10_BOVIN
AccessionPrimary (citable) accession number: Q2KHW7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 7, 2006
Last modified: February 19, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families