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Q2KHW7

- RGS10_BOVIN

UniProt

Q2KHW7 - RGS10_BOVIN

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Protein

Regulator of G-protein signaling 10

Gene
RGS10
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)-alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein By similarity.

GO - Molecular functioni

  1. GTPase activator activity Source: RefGenome

GO - Biological processi

  1. positive regulation of GTPase activity Source: GOC
  2. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Enzyme and pathway databases

ReactomeiREACT_210568. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 10
Short name:
RGS10
Gene namesi
Name:RGS10
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 26

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. nucleus Source: Ensembl
  3. plasma membrane Source: RefGenome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181Regulator of G-protein signaling 10PRO_0000244459Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi74 – 741S-palmitoyl cysteine By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PRIDEiQ2KHW7.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003425.

Structurei

3D structure databases

ProteinModelPortaliQ2KHW7.
SMRiQ2KHW7. Positions 33-172.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 156116RGSAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.

Phylogenomic databases

eggNOGiNOG271158.
GeneTreeiENSGT00700000104412.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiQ2KHW7.
KOiK16449.
OMAiPKSTAKW.
OrthoDBiEOG7XDBF0.
TreeFamiTF315837.

Family and domain databases

Gene3Di1.10.196.10. 1 hit.
InterProiIPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2KHW7-1 [UniParc]FASTAAdd to Basket

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MFNRAVSRLS RKRPPSDIHD SDGSSSSSHQ TPKSTAKWAS SLENLLEDPE    50
GVKRFREFLK KEFSEENVLF WLACEDFKKT QDKKQMQEKA KEIYMTFLSS 100
KASSQVNVEG QSRLNEKILE EPHPLMFQKL QDQIFNLMKY DSYSRFLKSD 150
LFLKHKRTEE EDEESPDAQT AAKRASRIYN T 181
Length:181
Mass (Da):21,195
Last modified:March 7, 2006 - v1
Checksum:iF722EFB8EFFE9801
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC112856 mRNA. Translation: AAI12857.1.
RefSeqiNP_001040005.1. NM_001046540.2.
UniGeneiBt.31630.

Genome annotation databases

EnsembliENSBTAT00000003425; ENSBTAP00000003425; ENSBTAG00000002647.
GeneIDi614550.
KEGGibta:614550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC112856 mRNA. Translation: AAI12857.1 .
RefSeqi NP_001040005.1. NM_001046540.2.
UniGenei Bt.31630.

3D structure databases

ProteinModelPortali Q2KHW7.
SMRi Q2KHW7. Positions 33-172.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000003425.

Proteomic databases

PRIDEi Q2KHW7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000003425 ; ENSBTAP00000003425 ; ENSBTAG00000002647 .
GeneIDi 614550.
KEGGi bta:614550.

Organism-specific databases

CTDi 6001.

Phylogenomic databases

eggNOGi NOG271158.
GeneTreei ENSGT00700000104412.
HOGENOMi HOG000233512.
HOVERGENi HBG013233.
InParanoidi Q2KHW7.
KOi K16449.
OMAi PKSTAKW.
OrthoDBi EOG7XDBF0.
TreeFami TF315837.

Enzyme and pathway databases

Reactomei REACT_210568. G alpha (i) signalling events.

Miscellaneous databases

NextBioi 20899157.

Family and domain databases

Gene3Di 1.10.196.10. 1 hit.
InterProi IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view ]
Pfami PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
PROSITEi PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiRGS10_BOVIN
AccessioniPrimary (citable) accession number: Q2KHW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 7, 2006
Last modified: September 3, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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