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Protein

Regulator of G-protein signaling 10

Gene

RGS10

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)-alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Enzyme and pathway databases

ReactomeiREACT_338486. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 10
Short name:
RGS10
Gene namesi
Name:RGS10
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 26

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181Regulator of G-protein signaling 10PRO_0000244459Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi74 – 741S-palmitoyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PRIDEiQ2KHW7.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003425.

Structurei

3D structure databases

ProteinModelPortaliQ2KHW7.
SMRiQ2KHW7. Positions 33-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 156116RGSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG271158.
GeneTreeiENSGT00760000119142.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiQ2KHW7.
KOiK16449.
OMAiPKSTAKW.
OrthoDBiEOG7XDBF0.
TreeFamiTF315837.

Family and domain databases

Gene3Di1.10.196.10. 1 hit.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2KHW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNRAVSRLS RKRPPSDIHD SDGSSSSSHQ TPKSTAKWAS SLENLLEDPE
60 70 80 90 100
GVKRFREFLK KEFSEENVLF WLACEDFKKT QDKKQMQEKA KEIYMTFLSS
110 120 130 140 150
KASSQVNVEG QSRLNEKILE EPHPLMFQKL QDQIFNLMKY DSYSRFLKSD
160 170 180
LFLKHKRTEE EDEESPDAQT AAKRASRIYN T
Length:181
Mass (Da):21,195
Last modified:March 7, 2006 - v1
Checksum:iF722EFB8EFFE9801
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112856 mRNA. Translation: AAI12857.1.
RefSeqiNP_001040005.1. NM_001046540.2.
UniGeneiBt.31630.

Genome annotation databases

EnsembliENSBTAT00000003425; ENSBTAP00000003425; ENSBTAG00000002647.
GeneIDi614550.
KEGGibta:614550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112856 mRNA. Translation: AAI12857.1.
RefSeqiNP_001040005.1. NM_001046540.2.
UniGeneiBt.31630.

3D structure databases

ProteinModelPortaliQ2KHW7.
SMRiQ2KHW7. Positions 33-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003425.

Proteomic databases

PRIDEiQ2KHW7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000003425; ENSBTAP00000003425; ENSBTAG00000002647.
GeneIDi614550.
KEGGibta:614550.

Organism-specific databases

CTDi6001.

Phylogenomic databases

eggNOGiNOG271158.
GeneTreeiENSGT00760000119142.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiQ2KHW7.
KOiK16449.
OMAiPKSTAKW.
OrthoDBiEOG7XDBF0.
TreeFamiTF315837.

Enzyme and pathway databases

ReactomeiREACT_338486. G alpha (i) signalling events.

Miscellaneous databases

NextBioi20899157.

Family and domain databases

Gene3Di1.10.196.10. 1 hit.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiRGS10_BOVIN
AccessioniPrimary (citable) accession number: Q2KHW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 7, 2006
Last modified: May 27, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.