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Q2KHW7

- RGS10_BOVIN

UniProt

Q2KHW7 - RGS10_BOVIN

Protein

Regulator of G-protein signaling 10

Gene

RGS10

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)-alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein By similarity.By similarity

    GO - Molecular functioni

    1. GTPase activator activity Source: RefGenome

    GO - Biological processi

    1. positive regulation of GTPase activity Source: GOC
    2. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Enzyme and pathway databases

    ReactomeiREACT_210568. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 10
    Short name:
    RGS10
    Gene namesi
    Name:RGS10
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 26

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. nucleus Source: Ensembl
    3. plasma membrane Source: RefGenome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 181181Regulator of G-protein signaling 10PRO_0000244459Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi74 – 741S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiQ2KHW7.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000003425.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2KHW7.
    SMRiQ2KHW7. Positions 33-172.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini41 – 156116RGSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG271158.
    GeneTreeiENSGT00700000104412.
    HOGENOMiHOG000233512.
    HOVERGENiHBG013233.
    InParanoidiQ2KHW7.
    KOiK16449.
    OMAiPKSTAKW.
    OrthoDBiEOG7XDBF0.
    TreeFamiTF315837.

    Family and domain databases

    Gene3Di1.10.196.10. 1 hit.
    InterProiIPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view]
    PfamiPF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    PROSITEiPS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2KHW7-1 [UniParc]FASTAAdd to Basket

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    MFNRAVSRLS RKRPPSDIHD SDGSSSSSHQ TPKSTAKWAS SLENLLEDPE    50
    GVKRFREFLK KEFSEENVLF WLACEDFKKT QDKKQMQEKA KEIYMTFLSS 100
    KASSQVNVEG QSRLNEKILE EPHPLMFQKL QDQIFNLMKY DSYSRFLKSD 150
    LFLKHKRTEE EDEESPDAQT AAKRASRIYN T 181
    Length:181
    Mass (Da):21,195
    Last modified:March 7, 2006 - v1
    Checksum:iF722EFB8EFFE9801
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC112856 mRNA. Translation: AAI12857.1.
    RefSeqiNP_001040005.1. NM_001046540.2.
    UniGeneiBt.31630.

    Genome annotation databases

    EnsembliENSBTAT00000003425; ENSBTAP00000003425; ENSBTAG00000002647.
    GeneIDi614550.
    KEGGibta:614550.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC112856 mRNA. Translation: AAI12857.1 .
    RefSeqi NP_001040005.1. NM_001046540.2.
    UniGenei Bt.31630.

    3D structure databases

    ProteinModelPortali Q2KHW7.
    SMRi Q2KHW7. Positions 33-172.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000003425.

    Proteomic databases

    PRIDEi Q2KHW7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000003425 ; ENSBTAP00000003425 ; ENSBTAG00000002647 .
    GeneIDi 614550.
    KEGGi bta:614550.

    Organism-specific databases

    CTDi 6001.

    Phylogenomic databases

    eggNOGi NOG271158.
    GeneTreei ENSGT00700000104412.
    HOGENOMi HOG000233512.
    HOVERGENi HBG013233.
    InParanoidi Q2KHW7.
    KOi K16449.
    OMAi PKSTAKW.
    OrthoDBi EOG7XDBF0.
    TreeFami TF315837.

    Enzyme and pathway databases

    Reactomei REACT_210568. G alpha (i) signalling events.

    Miscellaneous databases

    NextBioi 20899157.

    Family and domain databases

    Gene3Di 1.10.196.10. 1 hit.
    InterProi IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view ]
    Pfami PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    PROSITEi PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Hypothalamus.

    Entry informationi

    Entry nameiRGS10_BOVIN
    AccessioniPrimary (citable) accession number: Q2KHW7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3