Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Long-chain-fatty-acid--CoA ligase ACSBG1

Gene

ACSBG1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids (By similarity).By similarity

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC
  3. very long-chain fatty acid-CoA ligase activity Source: Ensembl

GO - Biological processi

  1. response to glucocorticoid Source: Ensembl
  2. very long-chain fatty acid metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase ACSBG1 (EC:6.2.1.3)
Alternative name(s):
Acyl-CoA synthetase bubblegum family member 1
Gene namesi
Name:ACSBG1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 21

Subcellular locationi

Cytoplasm By similarity. Cytoplasmic vesicle By similarity. Microsome By similarity. Endoplasmic reticulum By similarity

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
  2. endoplasmic reticulum Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 726726Long-chain-fatty-acid--CoA ligase ACSBG1PRO_0000315807Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei641 – 6411PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ2KHW5.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000043854.

Structurei

3D structure databases

ProteinModelPortaliQ2KHW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1022.
GeneTreeiENSGT00690000101725.
HOGENOMiHOG000230004.
HOVERGENiHBG054660.
InParanoidiQ2KHW5.
KOiK15013.
OMAiTQQPNQC.
OrthoDBiEOG7B5WVB.
TreeFamiTF354286.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2KHW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDSRAAPQE SLLDASLGTT QENVGTSSLT DGQTLSKEPL SHALKLSTPE
60 70 80 90 100
KVKDAQLNPP EEALWTTRAD GRVRLRIDPI CSQTPRTVHQ MFSTTLDKYG
110 120 130 140 150
DLSAMGFKRQ GTWEHISYTQ YYLLARKAAK GFLKLGLERA HSVAILAFNS
160 170 180 190 200
PEWFFSAVGA VFGGGIITGI YTTSSPEACQ YIAYDCRANI IVVDTQKQLE
210 220 230 240 250
KILKIWKHLP HLKAVVIYRE APPMRMPSVY TMEELMELGN EVPEEALDVI
260 270 280 290 300
INAQKPNQCC ALVYTSGTTG NPKGVMLSQD NITWTARYGS QAGDIQPAEI
310 320 330 340 350
QQEVVVSYLP LSHIAAQIYD LWTGIQWGAQ VCFAEPDALK GSLVNTLREV
360 370 380 390 400
EPTSHMGVPR VWEKIMEQIQ EVAAQSGFIW RKMLLWAMSV TLEQNLTCPS
410 420 430 440 450
SDLKPFTTRL ADYLVLAKVR QALGFAKCQK NFYGAAPMTA ETQHFFLGLN
460 470 480 490 500
IRLYAGYGLS ETSGPHFMSS PYNYRLYSSG KVVPGCQVKL VNEDAEGIGE
510 520 530 540 550
ICLWGRTIFM GYLNMEDKTC EAIDAEGWLH TGDTGRLDAD GFLYITGRLK
560 570 580 590 600
ELIITAGGEN VPPVPIEEAV KTELPIIRNA MLIGDQRKFL SMLLTLKCTL
610 620 630 640 650
DPDTFEPTDN LTEQAVEFCQ RVGSKATTVS EVVGKKDEAV YQAIEEGIQR
660 670 680 690 700
VNMNAAARPY HIQKWAILEK DFSISGGELG PTMKLKRLAV LEKYKDVIDS
710 720
FYQEQKSKQG SSLPGFSLRW QTGASS
Length:726
Mass (Da):80,585
Last modified:March 7, 2006 - v1
Checksum:i22EC0E08E143FB72
GO

Sequence cautioni

The sequence AAX46711.1 differs from that shown. Reason: Frameshift at position 705. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021864 mRNA. Translation: AAX46711.1. Frameshift.
BC112858 mRNA. Translation: AAI12859.1.
RefSeqiNP_001019719.1. NM_001024548.1.
UniGeneiBt.37833.

Genome annotation databases

EnsembliENSBTAT00000046569; ENSBTAP00000043854; ENSBTAG00000006231.
GeneIDi515577.
KEGGibta:515577.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021864 mRNA. Translation: AAX46711.1. Frameshift.
BC112858 mRNA. Translation: AAI12859.1.
RefSeqiNP_001019719.1. NM_001024548.1.
UniGeneiBt.37833.

3D structure databases

ProteinModelPortaliQ2KHW5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000043854.

Proteomic databases

PRIDEiQ2KHW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000046569; ENSBTAP00000043854; ENSBTAG00000006231.
GeneIDi515577.
KEGGibta:515577.

Organism-specific databases

CTDi23205.

Phylogenomic databases

eggNOGiCOG1022.
GeneTreeiENSGT00690000101725.
HOGENOMiHOG000230004.
HOVERGENiHBG054660.
InParanoidiQ2KHW5.
KOiK15013.
OMAiTQQPNQC.
OrthoDBiEOG7B5WVB.
TreeFamiTF354286.

Miscellaneous databases

NextBioi20871900.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiACBG1_BOVIN
AccessioniPrimary (citable) accession number: Q2KHW5
Secondary accession number(s): Q58CT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 7, 2006
Last modified: March 4, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.