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Q2KHW5

- ACBG1_BOVIN

UniProt

Q2KHW5 - ACBG1_BOVIN

Protein

Long-chain-fatty-acid--CoA ligase ACSBG1

Gene

ACSBG1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids By similarity.By similarity

    Catalytic activityi

    ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC
    3. very long-chain fatty acid-CoA ligase activity Source: Ensembl

    GO - Biological processi

    1. response to glucocorticoid Source: Ensembl
    2. very long-chain fatty acid metabolic process Source: Ensembl

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Long-chain-fatty-acid--CoA ligase ACSBG1 (EC:6.2.1.3)
    Alternative name(s):
    Acyl-CoA synthetase bubblegum family member 1
    Gene namesi
    Name:ACSBG1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 21

    Subcellular locationi

    Cytoplasm By similarity. Cytoplasmic vesicle By similarity. Microsome By similarity. Endoplasmic reticulum By similarity

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
    2. endoplasmic reticulum Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 726726Long-chain-fatty-acid--CoA ligase ACSBG1PRO_0000315807Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei641 – 6411PhosphotyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ2KHW5.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000043854.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2KHW5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1022.
    GeneTreeiENSGT00690000101725.
    HOGENOMiHOG000230004.
    HOVERGENiHBG054660.
    InParanoidiQ2KHW5.
    KOiK15013.
    OMAiFYQEQKM.
    OrthoDBiEOG7B5WVB.
    TreeFamiTF354286.

    Family and domain databases

    InterProiIPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    [Graphical view]
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2KHW5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPDSRAAPQE SLLDASLGTT QENVGTSSLT DGQTLSKEPL SHALKLSTPE    50
    KVKDAQLNPP EEALWTTRAD GRVRLRIDPI CSQTPRTVHQ MFSTTLDKYG 100
    DLSAMGFKRQ GTWEHISYTQ YYLLARKAAK GFLKLGLERA HSVAILAFNS 150
    PEWFFSAVGA VFGGGIITGI YTTSSPEACQ YIAYDCRANI IVVDTQKQLE 200
    KILKIWKHLP HLKAVVIYRE APPMRMPSVY TMEELMELGN EVPEEALDVI 250
    INAQKPNQCC ALVYTSGTTG NPKGVMLSQD NITWTARYGS QAGDIQPAEI 300
    QQEVVVSYLP LSHIAAQIYD LWTGIQWGAQ VCFAEPDALK GSLVNTLREV 350
    EPTSHMGVPR VWEKIMEQIQ EVAAQSGFIW RKMLLWAMSV TLEQNLTCPS 400
    SDLKPFTTRL ADYLVLAKVR QALGFAKCQK NFYGAAPMTA ETQHFFLGLN 450
    IRLYAGYGLS ETSGPHFMSS PYNYRLYSSG KVVPGCQVKL VNEDAEGIGE 500
    ICLWGRTIFM GYLNMEDKTC EAIDAEGWLH TGDTGRLDAD GFLYITGRLK 550
    ELIITAGGEN VPPVPIEEAV KTELPIIRNA MLIGDQRKFL SMLLTLKCTL 600
    DPDTFEPTDN LTEQAVEFCQ RVGSKATTVS EVVGKKDEAV YQAIEEGIQR 650
    VNMNAAARPY HIQKWAILEK DFSISGGELG PTMKLKRLAV LEKYKDVIDS 700
    FYQEQKSKQG SSLPGFSLRW QTGASS 726
    Length:726
    Mass (Da):80,585
    Last modified:March 7, 2006 - v1
    Checksum:i22EC0E08E143FB72
    GO

    Sequence cautioni

    The sequence AAX46711.1 differs from that shown. Reason: Frameshift at position 705.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT021864 mRNA. Translation: AAX46711.1. Frameshift.
    BC112858 mRNA. Translation: AAI12859.1.
    RefSeqiNP_001019719.1. NM_001024548.1.
    UniGeneiBt.37833.

    Genome annotation databases

    EnsembliENSBTAT00000008182; ENSBTAP00000008182; ENSBTAG00000006231.
    ENSBTAT00000046569; ENSBTAP00000043854; ENSBTAG00000006231.
    GeneIDi515577.
    KEGGibta:515577.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT021864 mRNA. Translation: AAX46711.1 . Frameshift.
    BC112858 mRNA. Translation: AAI12859.1 .
    RefSeqi NP_001019719.1. NM_001024548.1.
    UniGenei Bt.37833.

    3D structure databases

    ProteinModelPortali Q2KHW5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000043854.

    Proteomic databases

    PRIDEi Q2KHW5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000008182 ; ENSBTAP00000008182 ; ENSBTAG00000006231 .
    ENSBTAT00000046569 ; ENSBTAP00000043854 ; ENSBTAG00000006231 .
    GeneIDi 515577.
    KEGGi bta:515577.

    Organism-specific databases

    CTDi 23205.

    Phylogenomic databases

    eggNOGi COG1022.
    GeneTreei ENSGT00690000101725.
    HOGENOMi HOG000230004.
    HOVERGENi HBG054660.
    InParanoidi Q2KHW5.
    KOi K15013.
    OMAi FYQEQKM.
    OrthoDBi EOG7B5WVB.
    TreeFami TF354286.

    Miscellaneous databases

    NextBioi 20871900.

    Family and domain databases

    InterProi IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    [Graphical view ]
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Hypothalamus.

    Entry informationi

    Entry nameiACBG1_BOVIN
    AccessioniPrimary (citable) accession number: Q2KHW5
    Secondary accession number(s): Q58CT3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3