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Q2KHW5 (ACBG1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Long-chain-fatty-acid--CoA ligase ACSBG1

EC=6.2.1.3
Alternative name(s):
Acyl-CoA synthetase bubblegum family member 1
Gene names
Name:ACSBG1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length726 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids By similarity.

Catalytic activity

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Subcellular location

Cytoplasm By similarity. Cytoplasmic vesicle By similarity. Microsome By similarity. Endoplasmic reticulum By similarity.

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily.

Sequence caution

The sequence AAX46711.1 differs from that shown. Reason: Frameshift at position 705.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 726726Long-chain-fatty-acid--CoA ligase ACSBG1
PRO_0000315807

Amino acid modifications

Modified residue6411Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2KHW5 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: 22EC0E08E143FB72

FASTA72680,585
        10         20         30         40         50         60 
MPDSRAAPQE SLLDASLGTT QENVGTSSLT DGQTLSKEPL SHALKLSTPE KVKDAQLNPP 

        70         80         90        100        110        120 
EEALWTTRAD GRVRLRIDPI CSQTPRTVHQ MFSTTLDKYG DLSAMGFKRQ GTWEHISYTQ 

       130        140        150        160        170        180 
YYLLARKAAK GFLKLGLERA HSVAILAFNS PEWFFSAVGA VFGGGIITGI YTTSSPEACQ 

       190        200        210        220        230        240 
YIAYDCRANI IVVDTQKQLE KILKIWKHLP HLKAVVIYRE APPMRMPSVY TMEELMELGN 

       250        260        270        280        290        300 
EVPEEALDVI INAQKPNQCC ALVYTSGTTG NPKGVMLSQD NITWTARYGS QAGDIQPAEI 

       310        320        330        340        350        360 
QQEVVVSYLP LSHIAAQIYD LWTGIQWGAQ VCFAEPDALK GSLVNTLREV EPTSHMGVPR 

       370        380        390        400        410        420 
VWEKIMEQIQ EVAAQSGFIW RKMLLWAMSV TLEQNLTCPS SDLKPFTTRL ADYLVLAKVR 

       430        440        450        460        470        480 
QALGFAKCQK NFYGAAPMTA ETQHFFLGLN IRLYAGYGLS ETSGPHFMSS PYNYRLYSSG 

       490        500        510        520        530        540 
KVVPGCQVKL VNEDAEGIGE ICLWGRTIFM GYLNMEDKTC EAIDAEGWLH TGDTGRLDAD 

       550        560        570        580        590        600 
GFLYITGRLK ELIITAGGEN VPPVPIEEAV KTELPIIRNA MLIGDQRKFL SMLLTLKCTL 

       610        620        630        640        650        660 
DPDTFEPTDN LTEQAVEFCQ RVGSKATTVS EVVGKKDEAV YQAIEEGIQR VNMNAAARPY 

       670        680        690        700        710        720 
HIQKWAILEK DFSISGGELG PTMKLKRLAV LEKYKDVIDS FYQEQKSKQG SSLPGFSLRW 


QTGASS 

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References

[1]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Hypothalamus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BT021864 mRNA. Translation: AAX46711.1. Frameshift.
BC112858 mRNA. Translation: AAI12859.1.
RefSeqNP_001019719.1. NM_001024548.1.
UniGeneBt.37833.

3D structure databases

ProteinModelPortalQ2KHW5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000043854.

Proteomic databases

PRIDEQ2KHW5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000008182; ENSBTAP00000008182; ENSBTAG00000006231.
ENSBTAT00000046569; ENSBTAP00000043854; ENSBTAG00000006231.
GeneID515577.
KEGGbta:515577.

Organism-specific databases

CTD23205.

Phylogenomic databases

eggNOGCOG1022.
GeneTreeENSGT00690000101725.
HOGENOMHOG000230004.
HOVERGENHBG054660.
InParanoidQ2KHW5.
KOK15013.
OMATQQPNQC.
OrthoDBEOG7B5WVB.
TreeFamTF354286.

Family and domain databases

InterProIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20871900.

Entry information

Entry nameACBG1_BOVIN
AccessionPrimary (citable) accession number: Q2KHW5
Secondary accession number(s): Q58CT3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 7, 2006
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families