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Protein

Sorting nexin-8

Gene

SNX8

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei104Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei130Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei143Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-8
Gene namesi
Name:SNX8
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002901881 – 459Sorting nexin-8Add BLAST459

Proteomic databases

PaxDbiQ2KHV6.
PRIDEiQ2KHV6.

Expressioni

Gene expression databases

BgeeiENSBTAG00000013708.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018213.

Structurei

3D structure databases

ProteinModelPortaliQ2KHV6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 176PXPROSITE-ProRule annotationAdd BLAST109

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2273. Eukaryota.
COG5391. LUCA.
GeneTreeiENSGT00460000041594.
HOGENOMiHOG000252992.
HOVERGENiHBG017827.
InParanoidiQ2KHV6.
KOiK17922.
OMAiMMSATVQ.
OrthoDBiEOG091G0NVM.
TreeFamiTF314082.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2KHV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGGAMDPLP TAPGAAAAEA EVDEEADPPA ADSPVPPVSE PRAPDAGQMQ
60 70 80 90 100
VPPGNPLLLS LTLQELLARD AVQVELVPEK KGLFLKHVEY EVSSQRFKSC
110 120 130 140 150
VYRRYNDFVV FHETLLHKFP YRMVPALPPK RMLGADREFI EARRRALKRF
160 170 180 190 200
INLVARHPPF SEDTILKLFL SFSGPDVQNK LKESAQCLGD EFMNCRLAAR
210 220 230 240 250
AKDFLPADIQ TQFAMSRELI RNIYNSFHKL RDRAERMVSR AIDNAADLLI
260 270 280 290 300
FGKELSALGS DTTPLPSWAS LNSSTWGSLK QALKGLSVEF ALLADKAAQQ
310 320 330 340 350
GKQEENDVVE KLNLFLDLLQ SYKDLCERHE KGVLHKHQRA LHKYSLMKRQ
360 370 380 390 400
MVSAAVQSRE PESMEQLESR IVQQENVIQT MELRSHFSLY CLHQETQLVH
410 420 430 440 450
VYLPLTSHIL GAFVNSQIQG HKEMSKVWND LQPKLRCLFV GPHGAPAPPR

PPQDGLSAH
Length:459
Mass (Da):51,619
Last modified:March 7, 2006 - v1
Checksum:i572458DB2C96518E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112867 mRNA. Translation: AAI12868.1.
RefSeqiNP_001039998.1. NM_001046533.2.
UniGeneiBt.28467.

Genome annotation databases

EnsembliENSBTAT00000018213; ENSBTAP00000018213; ENSBTAG00000013708.
GeneIDi614344.
KEGGibta:614344.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112867 mRNA. Translation: AAI12868.1.
RefSeqiNP_001039998.1. NM_001046533.2.
UniGeneiBt.28467.

3D structure databases

ProteinModelPortaliQ2KHV6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018213.

Proteomic databases

PaxDbiQ2KHV6.
PRIDEiQ2KHV6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000018213; ENSBTAP00000018213; ENSBTAG00000013708.
GeneIDi614344.
KEGGibta:614344.

Organism-specific databases

CTDi29886.

Phylogenomic databases

eggNOGiKOG2273. Eukaryota.
COG5391. LUCA.
GeneTreeiENSGT00460000041594.
HOGENOMiHOG000252992.
HOVERGENiHBG017827.
InParanoidiQ2KHV6.
KOiK17922.
OMAiMMSATVQ.
OrthoDBiEOG091G0NVM.
TreeFamiTF314082.

Gene expression databases

BgeeiENSBTAG00000013708.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNX8_BOVIN
AccessioniPrimary (citable) accession number: Q2KHV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: March 7, 2006
Last modified: September 7, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.