Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sorting nexin-8

Gene

SNX8

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei104Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei130Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei143Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-8
Gene namesi
Name:SNX8
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002901881 – 459Sorting nexin-8Add BLAST459

Proteomic databases

PaxDbiQ2KHV6.
PRIDEiQ2KHV6.

Expressioni

Gene expression databases

BgeeiENSBTAG00000013708.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018213.

Structurei

3D structure databases

ProteinModelPortaliQ2KHV6.
SMRiQ2KHV6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 176PXPROSITE-ProRule annotationAdd BLAST109

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Phylogenomic databases

eggNOGiKOG2273. Eukaryota.
COG5391. LUCA.
GeneTreeiENSGT00460000041594.
HOGENOMiHOG000252992.
HOVERGENiHBG017827.
InParanoidiQ2KHV6.
KOiK17922.
OMAiIRNIYNS.
OrthoDBiEOG091G0NVM.
TreeFamiTF314082.

Family and domain databases

CDDicd06866. PX_SNX8_Mvp1p_like. 1 hit.
Gene3Di1.20.1270.60. 1 hit.
3.30.1520.10. 1 hit.
InterProiView protein in InterPro
IPR027267. AH/BAR_dom_sf.
IPR001683. Phox.
IPR036871. PX_dom_sf.
IPR028662. SNX8/Mvp1.
IPR035704. SNX8/Mvp1_PX.
PANTHERiPTHR10555:SF165. PTHR10555:SF165. 1 hit.
PfamiView protein in Pfam
PF00787. PX. 1 hit.
SMARTiView protein in SMART
SM00312. PX. 1 hit.
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiView protein in PROSITE
PS50195. PX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2KHV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGGAMDPLP TAPGAAAAEA EVDEEADPPA ADSPVPPVSE PRAPDAGQMQ
60 70 80 90 100
VPPGNPLLLS LTLQELLARD AVQVELVPEK KGLFLKHVEY EVSSQRFKSC
110 120 130 140 150
VYRRYNDFVV FHETLLHKFP YRMVPALPPK RMLGADREFI EARRRALKRF
160 170 180 190 200
INLVARHPPF SEDTILKLFL SFSGPDVQNK LKESAQCLGD EFMNCRLAAR
210 220 230 240 250
AKDFLPADIQ TQFAMSRELI RNIYNSFHKL RDRAERMVSR AIDNAADLLI
260 270 280 290 300
FGKELSALGS DTTPLPSWAS LNSSTWGSLK QALKGLSVEF ALLADKAAQQ
310 320 330 340 350
GKQEENDVVE KLNLFLDLLQ SYKDLCERHE KGVLHKHQRA LHKYSLMKRQ
360 370 380 390 400
MVSAAVQSRE PESMEQLESR IVQQENVIQT MELRSHFSLY CLHQETQLVH
410 420 430 440 450
VYLPLTSHIL GAFVNSQIQG HKEMSKVWND LQPKLRCLFV GPHGAPAPPR

PPQDGLSAH
Length:459
Mass (Da):51,619
Last modified:March 7, 2006 - v1
Checksum:i572458DB2C96518E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112867 mRNA. Translation: AAI12868.1.
RefSeqiNP_001039998.1. NM_001046533.2.
UniGeneiBt.28467.

Genome annotation databases

EnsembliENSBTAT00000018213; ENSBTAP00000018213; ENSBTAG00000013708.
GeneIDi614344.
KEGGibta:614344.

Similar proteinsi

Entry informationi

Entry nameiSNX8_BOVIN
AccessioniPrimary (citable) accession number: Q2KHV6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: March 7, 2006
Last modified: November 22, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families