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Protein

Presenilins-associated rhomboid-like protein, mitochondrial

Gene

PARL

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity).By similarity

Catalytic activityi

Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei275NucleophileBy similarity1
Active sitei333By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

ReactomeiR-BTA-8949664 Processing of SMDT1

Names & Taxonomyi

Protein namesi
Recommended name:
Presenilins-associated rhomboid-like protein, mitochondrial (EC:3.4.21.105)
Alternative name(s):
Mitochondrial intramembrane cleaving protease PARL
Cleaved into the following chain:
P-beta
Short name:
Pbeta
Gene namesi
Name:PARL
Synonyms:PSARL
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 1

Organism-specific databases

VGNCiVGNC:53595 PARL

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini53 – 99Mitochondrial matrixSequence analysisAdd BLAST47
Transmembranei100 – 119HelicalSequence analysisAdd BLAST20
Topological domaini120 – 165Mitochondrial intermembraneSequence analysisAdd BLAST46
Transmembranei166 – 185HelicalSequence analysisAdd BLAST20
Topological domaini186 – 205Mitochondrial matrixSequence analysisAdd BLAST20
Transmembranei206 – 228HelicalSequence analysisAdd BLAST23
Topological domaini229 – 242Mitochondrial intermembraneSequence analysisAdd BLAST14
Transmembranei243 – 260HelicalSequence analysisAdd BLAST18
Topological domaini261 – 270Mitochondrial matrixSequence analysis10
Transmembranei271 – 287HelicalSequence analysisAdd BLAST17
Topological domaini288 – 293Mitochondrial intermembraneSequence analysis6
Transmembranei294 – 316HelicalSequence analysisAdd BLAST23
Topological domaini317 – 330Mitochondrial matrixSequence analysisAdd BLAST14
Transmembranei331 – 352HelicalSequence analysisAdd BLAST22
Topological domaini353 – 377Mitochondrial intermembraneSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 52MitochondrionBy similarityAdd BLAST52
ChainiPRO_000024509353 – 377Presenilins-associated rhomboid-like protein, mitochondrialAdd BLAST325
PeptideiPRO_000024509453 – 75P-betaBy similarityAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei65PhosphoserineBy similarity1
Modified residuei68PhosphoserineBy similarity1

Post-translational modificationi

P-beta is proteolytically processed (beta-cleavage) in a PARL-dependent manner.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ2KHV4
PRIDEiQ2KHV4

Expressioni

Gene expression databases

BgeeiENSBTAG00000014460

Interactioni

Subunit structurei

Interacts with PSEN1 and PSEN2. Binds OPA1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019227

Structurei

3D structure databases

ProteinModelPortaliQ2KHV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S54 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2980 Eukaryota
COG0705 LUCA
GeneTreeiENSGT00390000013063
HOGENOMiHOG000230670
HOVERGENiHBG082107
InParanoidiQ2KHV4
KOiK09650
OMAiHEMRTNS
OrthoDBiEOG091G0B3Z
TreeFamiTF313603

Family and domain databases

Gene3Di1.20.1540.10, 1 hit
InterProiView protein in InterPro
IPR022764 Peptidase_S54_rhomboid_dom
IPR035952 Rhomboid-like_sf
PfamiView protein in Pfam
PF01694 Rhomboid, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2KHV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWRGWAQRG WGCGQAWTLP VCGGSYEELT AALAPSRLLR RRFNFFIQQK
60 70 80 90 100
CGFRKAPRKV EPRRSDTSSE AYKRSALIPP VEETAFYPSP YPIRTLVKPL
110 120 130 140 150
FFTVGFTGCA FGSAAIWQYE SLKSKVQSYF DGIKADWLDS IRPQKEGDFR
160 170 180 190 200
KEINKWWNNL SDGQRTVTGI IAANVFVFCL WRVPSLQRTM IRYFTSNPAS
210 220 230 240 250
KVLCSPMLLS TFSHFSLFHM AANMYVLWSF SSSIVNILGQ EQFMAVYLSA
260 270 280 290 300
GVISTFVSYV CKVATGRYGP SLGASGAIMT VLAAVCTKIP EGRLAIIFLP
310 320 330 340 350
MFTFTAGNAL KAIIAMDTAG MILGWKFFDH AAHLGGALFG IWYITYGHEL
360 370
IWKNREPLVK IWHEMRTNSP KKGGGSK
Length:377
Mass (Da):42,301
Last modified:March 7, 2006 - v1
Checksum:i657E9D56D803203D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4R → G in AAX08693 (PubMed:16305752).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020676 mRNA Translation: AAX08693.1
BT026291 mRNA Translation: ABG81447.1
BT029889 mRNA Translation: ABM06139.1
BC112869 mRNA Translation: AAI12870.1
RefSeqiNP_001015596.1, NM_001015596.1
UniGeneiBt.4331

Genome annotation databases

EnsembliENSBTAT00000019227; ENSBTAP00000019227; ENSBTAG00000014460
GeneIDi514191
KEGGibta:514191

Similar proteinsi

Entry informationi

Entry nameiPARL_BOVIN
AccessioniPrimary (citable) accession number: Q2KHV4
Secondary accession number(s): A1L5A2, Q0V8C8, Q5EA93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 7, 2006
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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