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Protein

O-acetyl-ADP-ribose deacetylase MACROD1

Gene

MACROD1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei306SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
O-acetyl-ADP-ribose deacetylase MACROD1 (EC:3.2.2.-, EC:3.5.1.-)
Alternative name(s):
MACRO domain-containing protein 1
Protein LRP16
[Protein ADP-ribosylglutamate] hydrolase
Gene namesi
Name:MACROD1
Synonyms:LRP16
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 29

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003004601 – 325O-acetyl-ADP-ribose deacetylase MACROD1Add BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei96N6-succinyllysineBy similarity1
Modified residuei103N6-succinyllysineBy similarity1
Modified residuei129N6-succinyllysineBy similarity1
Modified residuei163N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ2KHU5.
PRIDEiQ2KHU5.

Expressioni

Gene expression databases

BgeeiENSBTAG00000017181.

Interactioni

Subunit structurei

Interacts with ESR1. Interacts with AR (via macro domain).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022832.

Structurei

3D structure databases

ProteinModelPortaliQ2KHU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini141 – 322MacroPROSITE-ProRule annotationAdd BLAST182

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni159 – 161Substrate bindingBy similarity3
Regioni172 – 174Substrate bindingBy similarity3
Regioni179 – 184Substrate bindingBy similarity6
Regioni267 – 273Substrate bindingBy similarity7

Sequence similaritiesi

Contains 1 Macro domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2633. Eukaryota.
COG2110. LUCA.
GeneTreeiENSGT00520000055566.
HOGENOMiHOG000086960.
HOVERGENiHBG052356.
InParanoidiQ2KHU5.
OMAiKITCGYR.
OrthoDBiEOG091G0NNH.
TreeFamiTF341440.

Family and domain databases

InterProiIPR002589. Macro_dom.
[Graphical view]
PfamiPF01661. Macro. 1 hit.
[Graphical view]
SMARTiSM00506. A1pp. 1 hit.
[Graphical view]
PROSITEiPS51154. MACRO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2KHU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLQSRVSRL LAQLRAAGQL LGAPRPWPGP SPGATRTRSS ACGPPASLSA
60 70 80 90 100
HHPRARTSAG VGAWGAAAVG RRAGVRTWAP LAMAAKVDLS TSTDWKEAKS
110 120 130 140 150
FLKGLSDKQR EEHYFCRDFV RLKKIPTWKE TAKGVTVKVE EPKYKKDKQL
160 170 180 190 200
NEKISLFRGD ITKLEVDAIV NAANSSLLGG GGVDGCIHRA AGPLLTDECR
210 220 230 240 250
TLQNCETGKA KITCGYRLPA KYVIHTVGPI AHGEPSASQA AELRSCYLSS
260 270 280 290 300
LDLLLEHRLR SAAFPCISTG VFGYPNEAAA EVVLTALREW LEQHKDKVDR
310 320
LIICVFLEKD ENIYRERLPH YFPVA
Length:325
Mass (Da):35,569
Last modified:March 7, 2006 - v1
Checksum:i9FC586B54CC85DDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112879 mRNA. Translation: AAI12880.1.
RefSeqiNP_001039974.1. NM_001046509.1.
UniGeneiBt.62929.

Genome annotation databases

EnsembliENSBTAT00000022832; ENSBTAP00000022832; ENSBTAG00000017181.
GeneIDi613568.
KEGGibta:613568.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112879 mRNA. Translation: AAI12880.1.
RefSeqiNP_001039974.1. NM_001046509.1.
UniGeneiBt.62929.

3D structure databases

ProteinModelPortaliQ2KHU5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022832.

Proteomic databases

PaxDbiQ2KHU5.
PRIDEiQ2KHU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000022832; ENSBTAP00000022832; ENSBTAG00000017181.
GeneIDi613568.
KEGGibta:613568.

Organism-specific databases

CTDi28992.

Phylogenomic databases

eggNOGiKOG2633. Eukaryota.
COG2110. LUCA.
GeneTreeiENSGT00520000055566.
HOGENOMiHOG000086960.
HOVERGENiHBG052356.
InParanoidiQ2KHU5.
OMAiKITCGYR.
OrthoDBiEOG091G0NNH.
TreeFamiTF341440.

Gene expression databases

BgeeiENSBTAG00000017181.

Family and domain databases

InterProiIPR002589. Macro_dom.
[Graphical view]
PfamiPF01661. Macro. 1 hit.
[Graphical view]
SMARTiSM00506. A1pp. 1 hit.
[Graphical view]
PROSITEiPS51154. MACRO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMACD1_BOVIN
AccessioniPrimary (citable) accession number: Q2KHU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 7, 2006
Last modified: September 7, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.