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Protein

Phosphoserine phosphatase

Gene

PSPH

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates (By similarity).By similarity

Catalytic activityi

O-phospho-L(or D)-serine + H2O = L(or D)-serine + phosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Pathwayi: L-serine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-serine from 3-phospho-D-glycerate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. D-3-phosphoglycerate dehydrogenase (PHGDH), D-3-phosphoglycerate dehydrogenase (PHGDH)
  2. Phosphoserine aminotransferase (PSAT1)
  3. Phosphoserine phosphatase (PSPH)
This subpathway is part of the pathway L-serine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-serine from 3-phospho-D-glycerate, the pathway L-serine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei20NucleophileBy similarity1
Metal bindingi20MagnesiumBy similarity1
Active sitei22Proton donorBy similarity1
Metal bindingi22Magnesium; via carbonyl oxygenBy similarity1
Binding sitei29SubstrateBy similarity1
Binding sitei65SubstrateBy similarity1
Binding sitei158SubstrateBy similarity1
Metal bindingi179MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAmino-acid biosynthesis, Serine biosynthesis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-977347 Serine biosynthesis
UniPathwayiUPA00135; UER00198

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoserine phosphatase (EC:3.1.3.3)
Short name:
PSP
Short name:
PSPase
Alternative name(s):
L-3-phosphoserine phosphatase
O-phosphoserine phosphohydrolase
Gene namesi
Name:PSPH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Organism-specific databases

VGNCiVGNC:33483 PSPH

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002444071 – 225Phosphoserine phosphataseAdd BLAST225

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ2KHU0
PRIDEiQ2KHU0

Expressioni

Gene expression databases

BgeeiENSBTAG00000013081

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017392

Structurei

3D structure databases

ProteinModelPortaliQ2KHU0
SMRiQ2KHU0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni109 – 110Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1615 Eukaryota
COG0560 LUCA
GeneTreeiENSGT00390000003115
HOGENOMiHOG000231116
HOVERGENiHBG057486
InParanoidiQ2KHU0
KOiK01079
OMAiRAQYYVT
OrthoDBiEOG091G0JBZ
TreeFamiTF315024

Family and domain databases

Gene3Di1.10.150.210, 2 hits
3.40.50.1000, 3 hits
InterProiView protein in InterPro
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR023190 Pser_Pase_dom_2
SUPFAMiSSF56784 SSF56784, 1 hit

Sequencei

Sequence statusi: Complete.

Q2KHU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSHSELRNL FCSADAVCFD VDSTVIQEEG IDELAKFCGV EDAVSEMTRQ
60 70 80 90 100
AMGGAVPFKA ALTQRLALIQ PSREQVQRLL AEHPPHLTPG IRELVSRLQE
110 120 130 140 150
RNVQVFLISG GFRSIVEHVA SKLNIPSTNV FANRLKFYFN GEYAGFDETQ
160 170 180 190 200
PTAESGGKGK VIKLLKEKFH FKKIVMVGDG ATDMEACPPA DAFIGFGGNV
210 220
IRQQVKDNAE WYITDFVELL GALEE
Length:225
Mass (Da):24,850
Last modified:March 7, 2006 - v1
Checksum:iB7E176431231DE17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112884 mRNA Translation: AAI12885.1
RefSeqiNP_001039820.1, NM_001046355.2
XP_005224980.1, XM_005224923.3
XP_005224981.1, XM_005224924.3
XP_005224982.1, XM_005224925.3
XP_010817735.1, XM_010819433.2
UniGeneiBt.25099

Genome annotation databases

EnsembliENSBTAT00000017392; ENSBTAP00000017392; ENSBTAG00000013081
GeneIDi533630
KEGGibta:533630

Similar proteinsi

Entry informationi

Entry nameiSERB_BOVIN
AccessioniPrimary (citable) accession number: Q2KHU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 7, 2006
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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