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Protein

RING finger protein 151

Gene

RNF151

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in acrosome formation of spermatids.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri20 – 58RING-typePROSITE-ProRule annotationAdd BLAST39
Zinc fingeri101 – 156TRAF-typePROSITE-ProRule annotationAdd BLAST56

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 151
Gene namesi
Name:RNF151
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:23235. RNF151.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179580.
PharmGKBiPA134992556.

Polymorphism and mutation databases

BioMutaiRNF151.
DMDMi119371030.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002552541 – 245RING finger protein 151Add BLAST245

Proteomic databases

PaxDbiQ2KHN1.
PRIDEiQ2KHN1.

PTM databases

iPTMnetiQ2KHN1.
PhosphoSitePlusiQ2KHN1.

Expressioni

Gene expression databases

BgeeiENSG00000179580.
CleanExiHS_RNF151.
ExpressionAtlasiQ2KHN1. baseline and differential.
GenevisibleiQ2KHN1. HS.

Organism-specific databases

HPAiHPA055054.

Interactioni

Subunit structurei

Interacts with DTNBP1.By similarity

Protein-protein interaction databases

BioGridi126977. 4 interactors.
IntActiQ2KHN1. 11 interactors.
STRINGi9606.ENSP00000456566.

Structurei

3D structure databases

ProteinModelPortaliQ2KHN1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
Contains 1 TRAF-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri20 – 58RING-typePROSITE-ProRule annotationAdd BLAST39
Zinc fingeri101 – 156TRAF-typePROSITE-ProRule annotationAdd BLAST56

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410KDGV. Eukaryota.
ENOG4111KUV. LUCA.
GeneTreeiENSGT00530000063647.
HOGENOMiHOG000154154.
HOVERGENiHBG087956.
InParanoidiQ2KHN1.
OMAiTCPLAHR.
OrthoDBiEOG091G0NOP.
PhylomeDBiQ2KHN1.
TreeFamiTF351947.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.90.890.10. 1 hit.
InterProiIPR013323. SIAH-type.
IPR008974. TRAF-like.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
IPR013010. Znf_SIAH.
IPR001293. Znf_TRAF.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 1 hit.
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
PS51081. ZF_SIAH. 1 hit.
PS50145. ZF_TRAF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2KHN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGGYDLNLF ASPPDSNFVC SVCHGVLKRP ARLPCSHIFC KKCILRWLAR
60 70 80 90 100
QKTCPCCRKE VKRKKVVHMN KLRKTIGRLE VKCKNADAGC IVTCPLAHRK
110 120 130 140 150
GHQDSCPFEL TACPNEGCTS QVPRGTLAEH RQHCQQGSQQ RCPLGCGATL
160 170 180 190 200
DPAERARHNC YRELHNAWSV RQERRRPLLL SLLRRVRWLD QATSVVRREL
210 220 230 240
AELSNFLEED TALLEGAPQE EAEAAPEGNV GAEVVGEPRA NIPCK
Length:245
Mass (Da):27,412
Last modified:March 7, 2006 - v1
Checksum:iD96AF6A1B7DDD755
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029501 mRNA. Translation: AAH29501.2.
BC113014 mRNA. Translation: AAI13015.1.
CCDSiCCDS58405.1.
RefSeqiNP_777563.2. NM_174903.4.
UniGeneiHs.99354.

Genome annotation databases

EnsembliENST00000569714; ENSP00000456566; ENSG00000179580.
GeneIDi146310.
KEGGihsa:146310.
UCSCiuc002cnt.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029501 mRNA. Translation: AAH29501.2.
BC113014 mRNA. Translation: AAI13015.1.
CCDSiCCDS58405.1.
RefSeqiNP_777563.2. NM_174903.4.
UniGeneiHs.99354.

3D structure databases

ProteinModelPortaliQ2KHN1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126977. 4 interactors.
IntActiQ2KHN1. 11 interactors.
STRINGi9606.ENSP00000456566.

PTM databases

iPTMnetiQ2KHN1.
PhosphoSitePlusiQ2KHN1.

Polymorphism and mutation databases

BioMutaiRNF151.
DMDMi119371030.

Proteomic databases

PaxDbiQ2KHN1.
PRIDEiQ2KHN1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000569714; ENSP00000456566; ENSG00000179580.
GeneIDi146310.
KEGGihsa:146310.
UCSCiuc002cnt.1. human.

Organism-specific databases

CTDi146310.
GeneCardsiRNF151.
HGNCiHGNC:23235. RNF151.
HPAiHPA055054.
neXtProtiNX_Q2KHN1.
OpenTargetsiENSG00000179580.
PharmGKBiPA134992556.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KDGV. Eukaryota.
ENOG4111KUV. LUCA.
GeneTreeiENSGT00530000063647.
HOGENOMiHOG000154154.
HOVERGENiHBG087956.
InParanoidiQ2KHN1.
OMAiTCPLAHR.
OrthoDBiEOG091G0NOP.
PhylomeDBiQ2KHN1.
TreeFamiTF351947.

Miscellaneous databases

GenomeRNAii146310.
PROiQ2KHN1.

Gene expression databases

BgeeiENSG00000179580.
CleanExiHS_RNF151.
ExpressionAtlasiQ2KHN1. baseline and differential.
GenevisibleiQ2KHN1. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.90.890.10. 1 hit.
InterProiIPR013323. SIAH-type.
IPR008974. TRAF-like.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
IPR013010. Znf_SIAH.
IPR001293. Znf_TRAF.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 1 hit.
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
PS51081. ZF_SIAH. 1 hit.
PS50145. ZF_TRAF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRN151_HUMAN
AccessioniPrimary (citable) accession number: Q2KHN1
Secondary accession number(s): Q8NHS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 7, 2006
Last modified: November 30, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.