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Protein

RING finger protein 151

Gene

RNF151

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in acrosome formation of spermatids.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri20 – 58RING-typeAdd BLAST39
Zinc fingeri101 – 156TRAF-typeAdd BLAST56

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDifferentiation, Spermatogenesis
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 151
Gene namesi
Name:RNF151
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000179580.9.
HGNCiHGNC:23235. RNF151.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179580.
PharmGKBiPA134992556.

Polymorphism and mutation databases

BioMutaiRNF151.
DMDMi119371030.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002552541 – 245RING finger protein 151Add BLAST245

Proteomic databases

PaxDbiQ2KHN1.
PeptideAtlasiQ2KHN1.
PRIDEiQ2KHN1.

PTM databases

iPTMnetiQ2KHN1.
PhosphoSitePlusiQ2KHN1.

Expressioni

Gene expression databases

BgeeiENSG00000179580.
CleanExiHS_RNF151.
ExpressionAtlasiQ2KHN1. baseline and differential.
GenevisibleiQ2KHN1. HS.

Interactioni

Subunit structurei

Interacts with DTNBP1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
PRPF3O433954EBI-12002474,EBI-744322

Protein-protein interaction databases

BioGridi126977. 57 interactors.
IntActiQ2KHN1. 12 interactors.
STRINGi9606.ENSP00000456566.

Structurei

3D structure databases

ProteinModelPortaliQ2KHN1.
SMRiQ2KHN1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri20 – 58RING-typeAdd BLAST39
Zinc fingeri101 – 156TRAF-typeAdd BLAST56

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410KDGV. Eukaryota.
ENOG4111KUV. LUCA.
GeneTreeiENSGT00530000063647.
HOGENOMiHOG000154154.
HOVERGENiHBG087956.
InParanoidiQ2KHN1.
OMAiHNCYREL.
OrthoDBiEOG091G0NOP.
PhylomeDBiQ2KHN1.
TreeFamiTF351947.

Family and domain databases

Gene3Di3.30.40.10. 3 hits.
InterProiView protein in InterPro
IPR008974. TRAF-like.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
IPR013010. Znf_SIAH.
IPR001293. Znf_TRAF.
SMARTiView protein in SMART
SM00184. RING. 1 hit.
SUPFAMiSSF49599. SSF49599. 1 hit.
PROSITEiView protein in PROSITE
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
PS51081. ZF_SIAH. 1 hit.
PS50145. ZF_TRAF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2KHN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGGYDLNLF ASPPDSNFVC SVCHGVLKRP ARLPCSHIFC KKCILRWLAR
60 70 80 90 100
QKTCPCCRKE VKRKKVVHMN KLRKTIGRLE VKCKNADAGC IVTCPLAHRK
110 120 130 140 150
GHQDSCPFEL TACPNEGCTS QVPRGTLAEH RQHCQQGSQQ RCPLGCGATL
160 170 180 190 200
DPAERARHNC YRELHNAWSV RQERRRPLLL SLLRRVRWLD QATSVVRREL
210 220 230 240
AELSNFLEED TALLEGAPQE EAEAAPEGNV GAEVVGEPRA NIPCK
Length:245
Mass (Da):27,412
Last modified:March 7, 2006 - v1
Checksum:iD96AF6A1B7DDD755
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029501 mRNA. Translation: AAH29501.2.
BC113014 mRNA. Translation: AAI13015.1.
CCDSiCCDS58405.1.
RefSeqiNP_001335640.1. NM_001348711.1.
NP_777563.2. NM_174903.5.
UniGeneiHs.99354.

Genome annotation databases

EnsembliENST00000569714; ENSP00000456566; ENSG00000179580.
GeneIDi146310.
KEGGihsa:146310.
UCSCiuc002cnt.1. human.

Similar proteinsi

Entry informationi

Entry nameiRN151_HUMAN
AccessioniPrimary (citable) accession number: Q2KHN1
Secondary accession number(s): Q8NHS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 7, 2006
Last modified: September 27, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM