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Protein

Protein moonraker

Gene

KIAA0753

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in centriole duplication. Positively regulates CEP63 centrosomal localization. Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:24613305, PubMed:26297806).1 Publication

GO - Biological processi

  • centriole replication Source: InterPro
  • protein localization to centrosome Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-32434-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein moonraker1 Publication
Short name:
MNR1 Publication
Gene namesi
Name:KIAA0753
Synonyms:MNR1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:29110. KIAA0753.

Subcellular locationi

GO - Cellular componenti

  • centriolar satellite Source: UniProtKB
  • centrosome Source: UniProtKB
  • cytoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198920.
PharmGKBiPA142671615.

Polymorphism and mutation databases

BioMutaiKIAA0753.
DMDMi296439322.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002801091 – 967Protein moonrakerAdd BLAST967

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei287PhosphoserineCombined sources1
Modified residuei409PhosphoserineCombined sources1
Modified residuei700PhosphoserineCombined sources1
Modified residuei826PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ2KHM9.
MaxQBiQ2KHM9.
PaxDbiQ2KHM9.
PeptideAtlasiQ2KHM9.
PRIDEiQ2KHM9.

2D gel databases

OGPiO94853.

PTM databases

iPTMnetiQ2KHM9.
PhosphoSitePlusiQ2KHM9.

Expressioni

Gene expression databases

BgeeiENSG00000198920.
CleanExiHS_KIAA0753.
ExpressionAtlasiQ2KHM9. baseline and differential.
GenevisibleiQ2KHM9. HS.

Organism-specific databases

HPAiHPA023057.
HPA023494.

Interactioni

Subunit structurei

Interacts with CEP63, PCM1 and WDR62.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CT55Q8WUE53EBI-2805604,EBI-6873363
FAM161AQ3B8203EBI-2805604,EBI-719941
GCC1Q96CN93EBI-2805604,EBI-746252
TCHPQ9BT923EBI-2805604,EBI-740781
TEAD4D3DUQ63EBI-2805604,EBI-10176734
USHBP1Q8N6Y03EBI-2805604,EBI-739895
ZNF114Q8NC263EBI-2805604,EBI-10265237

Protein-protein interaction databases

BioGridi115185. 123 interactors.
DIPiDIP-61716N.
IntActiQ2KHM9. 114 interactors.
STRINGi9606.ENSP00000355250.

Structurei

3D structure databases

ProteinModelPortaliQ2KHM9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili616 – 642Sequence analysisAdd BLAST27

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IKS4. Eukaryota.
ENOG410Z2QY. LUCA.
GeneTreeiENSGT00390000009714.
HOVERGENiHBG081825.
InParanoidiQ2KHM9.
OMAiPASPKCA.
OrthoDBiEOG091G01P0.
PhylomeDBiQ2KHM9.
TreeFamiTF331402.

Family and domain databases

InterProiIPR031447. MNR.
[Graphical view]
PfamiPF15718. MNR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2KHM9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPGQPASTC VHLAPRTQLD GRSDPKVLQT QNQLQFNRNV PTHSSNLAIR
60 70 80 90 100
YSCPHAIRIE KLKHSYNESY HCKDADCRVG PDLGSSVSFS VISQERLSYA
110 120 130 140 150
VHLARRDVKR RQFEKHIKEH HLRSQPQSSQ KCGHTKYKIP DHRVERKESK
160 170 180 190 200
SQAACQCSHQ PSKVEISSSG AKVYLYSSHP GQSDLTVPNS PPTHDPGLQP
210 220 230 240 250
HPRIGDHKNI SEQKSLLEVQ RLQKELSSCI HKIEEVTKKD RLEEALDPDE
260 270 280 290 300
ERRIRIRRQE QAARSARMLY VLQQQVKEIQ EELDKLSPHK IKHTKKSWAM
310 320 330 340 350
SKLAAAHRGA IRALQMFVTQ FTDRGEHPLP ARCKELGSLI RQLSLCSVKL
360 370 380 390 400
DADPSVPDVV IDILQQIEAL ESLLEKKLSP KKVKKCFSEI RSRFPIGSQK
410 420 430 440 450
ALERWPSTSP KGERRPLTAK DTFPQETSRP SVAKQLLADK YQPDTELPET
460 470 480 490 500
QRLQSELDVL DADIVLEEGP FILDQSASFK DEVLAVAKTK AGKKKPVTEN
510 520 530 540 550
VPFRKKDTLA PARQQGLRKA ERGRQSQPHS KSRVQQTTVS SRLKMNRQPV
560 570 580 590 600
KDRKAPWIPP NPTSPPASPK CAAWLKVKTS PRDATKEPLQ QEDPQEESHL
610 620 630 640 650
TGAVEHEAAR LAWLDAETSK RLKELEELKA KEIDSMQKQR LDWLDAETSR
660 670 680 690 700
RTKELNELKA EEMYRLQQLS VSATHLADKV EEAVLDRLKP LLVKAQRVNS
710 720 730 740 750
TTEANIHLKD GSSVNTAKAQ PAQEVAAVDF ESNNIRQLDD FLEDCASELW
760 770 780 790 800
AVTHAKILGS ETLATVEDSK DSPDLEIMMR RMEEMEKYQE SVRQRYNKIA
810 820 830 840 850
YADPRLWMQE ENNDQKISAI SEKPLSPHPI RITKTVDRKD PAVNIMLERP
860 870 880 890 900
CNGNSLDESV GTEEGSEKRE APLLSLAEDS QQKEGRAPLF VPPGMQHSIG
910 920 930 940 950
DYCSRFEQYL RIISHEAVGS FNPWLIAESF SEELVDEALG AVAAELQDMC
960
EDYAEAVFTS EFLEAAT
Length:967
Mass (Da):109,407
Last modified:May 18, 2010 - v3
Checksum:i2245C5246165B8AA
GO
Isoform 2 (identifier: Q2KHM9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-299: Missing.

Show »
Length:668
Mass (Da):75,136
Checksum:i9E7545743FB62FF4
GO

Sequence cautioni

The sequence BAA34473 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti250E → K in BAF85565 (PubMed:14702039).Curated1
Sequence conflicti821S → G in BAA34473 (PubMed:9872452).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031065201H → Q.Corresponds to variant rs16955985dbSNPEnsembl.1
Natural variantiVAR_031066375E → D.Corresponds to variant rs9889363dbSNPEnsembl.1
Natural variantiVAR_031067375E → G.Corresponds to variant rs17794522dbSNPEnsembl.1
Natural variantiVAR_031068444D → N.3 PublicationsCorresponds to variant rs2289643dbSNPEnsembl.1
Natural variantiVAR_031069466L → P.3 PublicationsCorresponds to variant rs2289642dbSNPEnsembl.1
Natural variantiVAR_031070501V → M.Corresponds to variant rs11868877dbSNPEnsembl.1
Natural variantiVAR_031071566P → L.Corresponds to variant rs2304977dbSNPEnsembl.1
Natural variantiVAR_031072896Q → R.3 PublicationsCorresponds to variant rs1443417dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0235391 – 299Missing in isoform 2. 2 PublicationsAdd BLAST299

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018296 mRNA. Translation: BAA34473.2. Different initiation.
AK292876 mRNA. Translation: BAF85565.1.
AK296971 mRNA. Translation: BAH12465.1.
AC004706 Genomic DNA. No translation available.
AC015916 Genomic DNA. No translation available.
BC113016 mRNA. Translation: AAI13017.1.
BC113017 mRNA. Translation: AAI13018.1.
AL080108 mRNA. Translation: CAB45712.1.
CCDSiCCDS42247.1. [Q2KHM9-1]
PIRiT12550.
RefSeqiNP_055619.2. NM_014804.2. [Q2KHM9-1]
XP_006721675.1. XM_006721612.2. [Q2KHM9-2]
XP_016880945.1. XM_017025456.1. [Q2KHM9-2]
UniGeneiHs.28070.

Genome annotation databases

EnsembliENST00000361413; ENSP00000355250; ENSG00000198920. [Q2KHM9-1]
ENST00000572370; ENSP00000460050; ENSG00000198920. [Q2KHM9-2]
GeneIDi9851.
KEGGihsa:9851.
UCSCiuc002gde.5. human. [Q2KHM9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018296 mRNA. Translation: BAA34473.2. Different initiation.
AK292876 mRNA. Translation: BAF85565.1.
AK296971 mRNA. Translation: BAH12465.1.
AC004706 Genomic DNA. No translation available.
AC015916 Genomic DNA. No translation available.
BC113016 mRNA. Translation: AAI13017.1.
BC113017 mRNA. Translation: AAI13018.1.
AL080108 mRNA. Translation: CAB45712.1.
CCDSiCCDS42247.1. [Q2KHM9-1]
PIRiT12550.
RefSeqiNP_055619.2. NM_014804.2. [Q2KHM9-1]
XP_006721675.1. XM_006721612.2. [Q2KHM9-2]
XP_016880945.1. XM_017025456.1. [Q2KHM9-2]
UniGeneiHs.28070.

3D structure databases

ProteinModelPortaliQ2KHM9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115185. 123 interactors.
DIPiDIP-61716N.
IntActiQ2KHM9. 114 interactors.
STRINGi9606.ENSP00000355250.

PTM databases

iPTMnetiQ2KHM9.
PhosphoSitePlusiQ2KHM9.

Polymorphism and mutation databases

BioMutaiKIAA0753.
DMDMi296439322.

2D gel databases

OGPiO94853.

Proteomic databases

EPDiQ2KHM9.
MaxQBiQ2KHM9.
PaxDbiQ2KHM9.
PeptideAtlasiQ2KHM9.
PRIDEiQ2KHM9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361413; ENSP00000355250; ENSG00000198920. [Q2KHM9-1]
ENST00000572370; ENSP00000460050; ENSG00000198920. [Q2KHM9-2]
GeneIDi9851.
KEGGihsa:9851.
UCSCiuc002gde.5. human. [Q2KHM9-1]

Organism-specific databases

CTDi9851.
GeneCardsiKIAA0753.
HGNCiHGNC:29110. KIAA0753.
HPAiHPA023057.
HPA023494.
neXtProtiNX_Q2KHM9.
OpenTargetsiENSG00000198920.
PharmGKBiPA142671615.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKS4. Eukaryota.
ENOG410Z2QY. LUCA.
GeneTreeiENSGT00390000009714.
HOVERGENiHBG081825.
InParanoidiQ2KHM9.
OMAiPASPKCA.
OrthoDBiEOG091G01P0.
PhylomeDBiQ2KHM9.
TreeFamiTF331402.

Enzyme and pathway databases

BioCyciZFISH:G66-32434-MONOMER.

Miscellaneous databases

ChiTaRSiKIAA0753. human.
GenomeRNAii9851.
PROiQ2KHM9.

Gene expression databases

BgeeiENSG00000198920.
CleanExiHS_KIAA0753.
ExpressionAtlasiQ2KHM9. baseline and differential.
GenevisibleiQ2KHM9. HS.

Family and domain databases

InterProiIPR031447. MNR.
[Graphical view]
PfamiPF15718. MNR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMOONR_HUMAN
AccessioniPrimary (citable) accession number: Q2KHM9
Secondary accession number(s): A8KA11
, B7Z479, O94853, Q05D97, Q2KHN0, Q9UG45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 80 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.