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Protein

Protein moonraker

Gene

KIAA0753

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in centriole duplication. Positively regulates CEP63 centrosomal localization. Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:24613305, PubMed:26297806).1 Publication

GO - Biological processi

  • centriole replication Source: InterPro
  • protein localization to centrosome Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein moonraker1 Publication
Short name:
MNR1 Publication
Gene namesi
Name:KIAA0753
Synonyms:MNR1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:29110. KIAA0753.

Subcellular locationi

GO - Cellular componenti

  • centriolar satellite Source: UniProtKB
  • centrosome Source: UniProtKB
  • cytoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671615.

Polymorphism and mutation databases

BioMutaiKIAA0753.
DMDMi296439322.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 967967Protein moonrakerPRO_0000280109Add
BLAST

Proteomic databases

EPDiQ2KHM9.
MaxQBiQ2KHM9.
PaxDbiQ2KHM9.
PRIDEiQ2KHM9.

2D gel databases

OGPiO94853.

PTM databases

iPTMnetiQ2KHM9.
PhosphoSiteiQ2KHM9.

Expressioni

Gene expression databases

BgeeiQ2KHM9.
CleanExiHS_KIAA0753.
ExpressionAtlasiQ2KHM9. baseline and differential.
GenevisibleiQ2KHM9. HS.

Organism-specific databases

HPAiHPA023057.
HPA023494.

Interactioni

Subunit structurei

Interacts with CEP63, PCM1 and WDR62.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CT55Q8WUE53EBI-2805604,EBI-6873363
FAM161AQ3B8203EBI-2805604,EBI-719941
GCC1Q96CN93EBI-2805604,EBI-746252
TEAD4D3DUQ63EBI-2805604,EBI-10176734
USHBP1Q8N6Y03EBI-2805604,EBI-739895
ZNF114Q8NC263EBI-2805604,EBI-10265237

Protein-protein interaction databases

BioGridi115185. 123 interactions.
DIPiDIP-61716N.
IntActiQ2KHM9. 103 interactions.
STRINGi9606.ENSP00000355250.

Structurei

3D structure databases

ProteinModelPortaliQ2KHM9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili616 – 64227Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IKS4. Eukaryota.
ENOG410Z2QY. LUCA.
GeneTreeiENSGT00390000009714.
HOVERGENiHBG081825.
InParanoidiQ2KHM9.
OMAiPASPKCA.
OrthoDBiEOG7GQXV1.
PhylomeDBiQ2KHM9.
TreeFamiTF331402.

Family and domain databases

InterProiIPR031447. MNR.
[Graphical view]
PfamiPF15718. DUF4673. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2KHM9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPGQPASTC VHLAPRTQLD GRSDPKVLQT QNQLQFNRNV PTHSSNLAIR
60 70 80 90 100
YSCPHAIRIE KLKHSYNESY HCKDADCRVG PDLGSSVSFS VISQERLSYA
110 120 130 140 150
VHLARRDVKR RQFEKHIKEH HLRSQPQSSQ KCGHTKYKIP DHRVERKESK
160 170 180 190 200
SQAACQCSHQ PSKVEISSSG AKVYLYSSHP GQSDLTVPNS PPTHDPGLQP
210 220 230 240 250
HPRIGDHKNI SEQKSLLEVQ RLQKELSSCI HKIEEVTKKD RLEEALDPDE
260 270 280 290 300
ERRIRIRRQE QAARSARMLY VLQQQVKEIQ EELDKLSPHK IKHTKKSWAM
310 320 330 340 350
SKLAAAHRGA IRALQMFVTQ FTDRGEHPLP ARCKELGSLI RQLSLCSVKL
360 370 380 390 400
DADPSVPDVV IDILQQIEAL ESLLEKKLSP KKVKKCFSEI RSRFPIGSQK
410 420 430 440 450
ALERWPSTSP KGERRPLTAK DTFPQETSRP SVAKQLLADK YQPDTELPET
460 470 480 490 500
QRLQSELDVL DADIVLEEGP FILDQSASFK DEVLAVAKTK AGKKKPVTEN
510 520 530 540 550
VPFRKKDTLA PARQQGLRKA ERGRQSQPHS KSRVQQTTVS SRLKMNRQPV
560 570 580 590 600
KDRKAPWIPP NPTSPPASPK CAAWLKVKTS PRDATKEPLQ QEDPQEESHL
610 620 630 640 650
TGAVEHEAAR LAWLDAETSK RLKELEELKA KEIDSMQKQR LDWLDAETSR
660 670 680 690 700
RTKELNELKA EEMYRLQQLS VSATHLADKV EEAVLDRLKP LLVKAQRVNS
710 720 730 740 750
TTEANIHLKD GSSVNTAKAQ PAQEVAAVDF ESNNIRQLDD FLEDCASELW
760 770 780 790 800
AVTHAKILGS ETLATVEDSK DSPDLEIMMR RMEEMEKYQE SVRQRYNKIA
810 820 830 840 850
YADPRLWMQE ENNDQKISAI SEKPLSPHPI RITKTVDRKD PAVNIMLERP
860 870 880 890 900
CNGNSLDESV GTEEGSEKRE APLLSLAEDS QQKEGRAPLF VPPGMQHSIG
910 920 930 940 950
DYCSRFEQYL RIISHEAVGS FNPWLIAESF SEELVDEALG AVAAELQDMC
960
EDYAEAVFTS EFLEAAT
Length:967
Mass (Da):109,407
Last modified:May 18, 2010 - v3
Checksum:i2245C5246165B8AA
GO
Isoform 2 (identifier: Q2KHM9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-299: Missing.

Show »
Length:668
Mass (Da):75,136
Checksum:i9E7545743FB62FF4
GO

Sequence cautioni

The sequence BAA34473.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti250 – 2501E → K in BAF85565 (PubMed:14702039).Curated
Sequence conflicti821 – 8211S → G in BAA34473 (PubMed:9872452).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti201 – 2011H → Q.
Corresponds to variant rs16955985 [ dbSNP | Ensembl ].
VAR_031065
Natural varianti375 – 3751E → D.
Corresponds to variant rs9889363 [ dbSNP | Ensembl ].
VAR_031066
Natural varianti375 – 3751E → G.
Corresponds to variant rs17794522 [ dbSNP | Ensembl ].
VAR_031067
Natural varianti444 – 4441D → N.3 Publications
Corresponds to variant rs2289643 [ dbSNP | Ensembl ].
VAR_031068
Natural varianti466 – 4661L → P.3 Publications
Corresponds to variant rs2289642 [ dbSNP | Ensembl ].
VAR_031069
Natural varianti501 – 5011V → M.
Corresponds to variant rs11868877 [ dbSNP | Ensembl ].
VAR_031070
Natural varianti566 – 5661P → L.
Corresponds to variant rs2304977 [ dbSNP | Ensembl ].
VAR_031071
Natural varianti896 – 8961Q → R.3 Publications
Corresponds to variant rs1443417 [ dbSNP | Ensembl ].
VAR_031072

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 299299Missing in isoform 2. 2 PublicationsVSP_023539Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018296 mRNA. Translation: BAA34473.2. Different initiation.
AK292876 mRNA. Translation: BAF85565.1.
AK296971 mRNA. Translation: BAH12465.1.
AC004706 Genomic DNA. No translation available.
AC015916 Genomic DNA. No translation available.
BC113016 mRNA. Translation: AAI13017.1.
BC113017 mRNA. Translation: AAI13018.1.
AL080108 mRNA. Translation: CAB45712.1.
CCDSiCCDS42247.1. [Q2KHM9-1]
PIRiT12550.
RefSeqiNP_055619.2. NM_014804.2. [Q2KHM9-1]
XP_006721675.1. XM_006721612.1. [Q2KHM9-2]
UniGeneiHs.28070.

Genome annotation databases

EnsembliENST00000361413; ENSP00000355250; ENSG00000198920. [Q2KHM9-1]
ENST00000572370; ENSP00000460050; ENSG00000198920. [Q2KHM9-2]
GeneIDi9851.
KEGGihsa:9851.
UCSCiuc002gde.5. human. [Q2KHM9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018296 mRNA. Translation: BAA34473.2. Different initiation.
AK292876 mRNA. Translation: BAF85565.1.
AK296971 mRNA. Translation: BAH12465.1.
AC004706 Genomic DNA. No translation available.
AC015916 Genomic DNA. No translation available.
BC113016 mRNA. Translation: AAI13017.1.
BC113017 mRNA. Translation: AAI13018.1.
AL080108 mRNA. Translation: CAB45712.1.
CCDSiCCDS42247.1. [Q2KHM9-1]
PIRiT12550.
RefSeqiNP_055619.2. NM_014804.2. [Q2KHM9-1]
XP_006721675.1. XM_006721612.1. [Q2KHM9-2]
UniGeneiHs.28070.

3D structure databases

ProteinModelPortaliQ2KHM9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115185. 123 interactions.
DIPiDIP-61716N.
IntActiQ2KHM9. 103 interactions.
STRINGi9606.ENSP00000355250.

PTM databases

iPTMnetiQ2KHM9.
PhosphoSiteiQ2KHM9.

Polymorphism and mutation databases

BioMutaiKIAA0753.
DMDMi296439322.

2D gel databases

OGPiO94853.

Proteomic databases

EPDiQ2KHM9.
MaxQBiQ2KHM9.
PaxDbiQ2KHM9.
PRIDEiQ2KHM9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361413; ENSP00000355250; ENSG00000198920. [Q2KHM9-1]
ENST00000572370; ENSP00000460050; ENSG00000198920. [Q2KHM9-2]
GeneIDi9851.
KEGGihsa:9851.
UCSCiuc002gde.5. human. [Q2KHM9-1]

Organism-specific databases

CTDi9851.
GeneCardsiKIAA0753.
HGNCiHGNC:29110. KIAA0753.
HPAiHPA023057.
HPA023494.
neXtProtiNX_Q2KHM9.
PharmGKBiPA142671615.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKS4. Eukaryota.
ENOG410Z2QY. LUCA.
GeneTreeiENSGT00390000009714.
HOVERGENiHBG081825.
InParanoidiQ2KHM9.
OMAiPASPKCA.
OrthoDBiEOG7GQXV1.
PhylomeDBiQ2KHM9.
TreeFamiTF331402.

Miscellaneous databases

ChiTaRSiKIAA0753. human.
GenomeRNAii9851.
NextBioi37126.
PROiQ2KHM9.

Gene expression databases

BgeeiQ2KHM9.
CleanExiHS_KIAA0753.
ExpressionAtlasiQ2KHM9. baseline and differential.
GenevisibleiQ2KHM9. HS.

Family and domain databases

InterProiIPR031447. MNR.
[Graphical view]
PfamiPF15718. DUF4673. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. Ohara O., Suyama M., Nagase T., Ishikawa K., Kikuno R.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS ASN-444; PRO-466 AND ARG-896.
    Tissue: Tongue and Trachea.
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS ASN-444; PRO-466 AND ARG-896.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 404-967, VARIANTS ASN-444; PRO-466 AND ARG-896.
    Tissue: Uterus.
  7. "Proximity interactions among centrosome components identify regulators of centriole duplication."
    Firat-Karalar E.N., Rauniyar N., Yates J.R. III, Stearns T.
    Curr. Biol. 24:664-670(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CEP63, SUBCELLULAR LOCATION.
  8. "Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication."
    Kodani A., Yu T.W., Johnson J.R., Jayaraman D., Johnson T.L., Al-Gazali L., Sztriha L., Partlow J.N., Kim H., Krup A.L., Dammermann A., Krogan N., Walsh C.A., Reiter J.F.
    Elife 4:0-0(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH WDR62 AND PCM1.

Entry informationi

Entry nameiMOONR_HUMAN
AccessioniPrimary (citable) accession number: Q2KHM9
Secondary accession number(s): A8KA11
, B7Z479, O94853, Q05D97, Q2KHN0, Q9UG45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: May 18, 2010
Last modified: April 13, 2016
This is version 74 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.