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Q2KE51

- MASZ_RHIEC

UniProt

Q2KE51 - MASZ_RHIEC

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Protein
Malate synthase G
Gene
glcB, RHE_CH00052
Organism
Rhizobium etli (strain CFN 42 / ATCC 51251)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei116 – 1161Acetyl-CoA; via carbonyl oxygen By similarity
Binding sitei274 – 2741Acetyl-CoA By similarity
Binding sitei311 – 3111Acetyl-CoA By similarity
Active sitei338 – 3381Proton acceptor By similarity
Binding sitei338 – 3381Glyoxylate By similarity
Metal bindingi430 – 4301Magnesium By similarity
Binding sitei430 – 4301Glyoxylate By similarity
Metal bindingi458 – 4581Magnesium By similarity
Binding sitei539 – 5391Acetyl-CoA; via carbonyl oxygen By similarity
Active sitei629 – 6291Proton donor By similarity

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciRETL347834:GJJ0-52-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase G (EC:2.3.3.9)
Gene namesi
Name:glcB
Ordered Locus Names:RHE_CH00052
OrganismiRhizobium etli (strain CFN 42 / ATCC 51251)
Taxonomic identifieri347834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
ProteomesiUP000001936: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 723723Malate synthase GUniRule annotation
PRO_1000056921Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei615 – 6151Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi347834.RHE_CH00052.

Structurei

3D structure databases

ProteinModelPortaliQ2KE51.
SMRiQ2KE51. Positions 9-722.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni123 – 1242Acetyl-CoA binding By similarity
Regioni455 – 4584Glyoxylate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000220740.
KOiK01638.
OMAiARTENVD.
OrthoDBiEOG6HJ286.

Family and domain databases

Gene3Di2.170.170.11. 2 hits.
HAMAPiMF_00641. Malate_synth_G.
InterProiIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2KE51-1 [UniParc]FASTAAdd to Basket

« Hide

MSRIDKNGLA IETILHDFLT QEVLPGLAID ADRFFADFSA IVHDLAPRNR    50
ALLVKRDELQ TKIDDWYRQH GAPSDMDDYQ SFLRSIGYLL PEGSDFQVST 100
ANVDPEIASI AGPQLVVPVM NARYALNAAN ARWGSLYDAL YGTDAIPEND 150
GAEKGKGYNP KRGEKVIAWV RDFLDAAAPL QDSRWKDVGS FFVKDGMLVV 200
RSVDGEQTML GDGGHFAGYR GDAAAPAHIL LKNNGIHIDI VIDPTTAIGK 250
ADPAHISDVW LESAITTIMD CEDSIAAVDA EDKVVVYRNW LGLMKGDLQE 300
EVAKGGTTFL RKLNPDLDYT SPDGASFELH RRSLMLVRNV GHLMTNPAIL 350
DKDGNEVPEG IMDAVITGLI ALYDIGPTGR KKNSRTGSMY VVKPKMHGPE 400
EVAFAVEIFS RVEDALGMAR NTIKMGIMDE ERRTTINLKE CIRAARERVV 450
FINTGFLDRT GDEIHTSMEA GPMIRKGDMR QAAWISAYEN WNVDIGLECG 500
LSGHAQIGKG MWAMPDLMAA MLEQKIAHPK AGANTAWVPS PTAATLHATH 550
YHRVNVAKVQ QGLKDRARAR LSDILSVPVA VRPNWTPEEI QRELDNNAQG 600
ILGYVVRWID QGVGCSKVPD INNIGLMEDR ATLRISAQHM ANWLHHKVVT 650
EAQIVETMKR MAAIVDRQNE SDPAYRPMAG NFDDSIAFQA ALDLVLKGRE 700
QPNGYTEPVL HRRRLELKAK QSA 723
Length:723
Mass (Da):79,899
Last modified:March 7, 2006 - v1
Checksum:i01C9C009C1A9E813
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000133 Genomic DNA. Translation: ABC88885.1.
RefSeqiWP_011423456.1. NC_007761.1.
YP_467612.1. NC_007761.1.

Genome annotation databases

EnsemblBacteriaiABC88885; ABC88885; RHE_CH00052.
GeneIDi3893196.
KEGGiret:RHE_CH00052.
PATRICi23081380. VBIRhiEtl108884_0382.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000133 Genomic DNA. Translation: ABC88885.1 .
RefSeqi WP_011423456.1. NC_007761.1.
YP_467612.1. NC_007761.1.

3D structure databases

ProteinModelPortali Q2KE51.
SMRi Q2KE51. Positions 9-722.
ModBasei Search...

Protein-protein interaction databases

STRINGi 347834.RHE_CH00052.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC88885 ; ABC88885 ; RHE_CH00052 .
GeneIDi 3893196.
KEGGi ret:RHE_CH00052.
PATRICi 23081380. VBIRhiEtl108884_0382.

Phylogenomic databases

eggNOGi COG2225.
HOGENOMi HOG000220740.
KOi K01638.
OMAi ARTENVD.
OrthoDBi EOG6HJ286.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci RETL347834:GJJ0-52-MONOMER.

Family and domain databases

Gene3Di 2.170.170.11. 2 hits.
HAMAPi MF_00641. Malate_synth_G.
InterProi IPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CFN 42 / ATCC 51251.

Entry informationi

Entry nameiMASZ_RHIEC
AccessioniPrimary (citable) accession number: Q2KE51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 7, 2006
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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