Q2KDR5 (ADE_RHIEC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenine deaminase
Short name=ADE
EC=3.5.4.2

Alternative name(s):
Adenine aminohydrolase
Short name=AAH

Gene names

Ordered Locus Names:

RHE_CH00197

Organism

Rhizobium etli (strain CFN 42 / ATCC 51251) [Complete proteome] [HAMAP]

Taxonomic identifier

347834 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Rhizobium

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism By similarity. HAMAP MF_01962
Catalytic activity	Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01962
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_01962
Sequence similarities	Belongs to the adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	adenine deaminase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 322	322	Adenine deaminase HAMAP MF_01962		PRO_1000017690
Sites
	Active site	192	1	Proton donor By similarity
	Metal binding	11	1	Zinc; catalytic By similarity
	Metal binding	13	1	Zinc; catalytic By similarity
	Metal binding	189	1	Zinc; catalytic By similarity
	Metal binding	270	1	Zinc; catalytic By similarity
	Binding site	271	1	Substrate By similarity
	Site	213	1	Important for catalytic activity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2KDR5 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 68162FAE9963D7ED	FASTA	322	34,940
	10 20 30 40 50 60 MTSHLKKVEL HCHLEGAASP ALTEAQARKY GIDISGQLRD GVYIWHDFAS FLECYDKVSE 70 80 90 100 110 120 VYRTEEDYAL LTETYLDELA GINTIYSELI VSPDHGKRIG LGADAYISGV CEGIRRAKAK 130 140 150 160 170 180 SGIEARLIVT GERHFGPESV IGAAEYAAKA GNPLITGFNL AGEERMGRVA DYIRAFDIAR 190 200 210 220 230 240 DAGLGLTIHA GEVCGAFSVA DALDAVRPAR IGHGVRAIED LDLVKRLADL GTVLEVCPGS 250 260 270 280 290 300 NIALRVYPDF ASHPLRRLKE AGVRVTISSD DPPFFHTSLE REYALAAEAF GFGDAEIDAM 310 320 TRVAIEAAFV DEETRKALLA RL

References

[1]

"The partitioned Rhizobium etli genome: genetic and metabolic redundancy in seven interacting replicons." Gonzalez V., Santamaria R.I., Bustos P., Hernandez-Gonzalez I., Medrano-Soto A., Moreno-Hagelsieb G., Janga S.C., Ramirez M.A., Jimenez-Jacinto V., Collado-Vides J., Davila G. Proc. Natl. Acad. Sci. U.S.A. 103:3834-3839(2006) [PubMed: 16505379] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CFN 42 / ATCC 51251.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000133 Genomic DNA. Translation: ABC89021.1.
RefSeq	YP_467748.1. NC_007761.1.
3D structure databases
ProteinModelPortal	Q2KDR5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2KDR5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3890897.
GenomeReviews	Gene locus RHE_CH00197 in contig CP000133_GR.
KEGG	ret:RHE_CH00197.
PATRIC	23081686. VBIRhiEtl108884_0528.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1816.
HOGENOM	HBG630382.
OMA	AELHVHH.
PhylomeDB	Q2KDR5.
ProtClustDB	PRK09358.
Family and domain databases
HAMAP	MF_01962. Adenine_deaminase. [Tree]
InterPro	IPR001365. A/AMP_deaminase_dom. IPR006330. A_deaminase. [Graphical view]
KO	K01488.
PANTHER	PTHR11409:SF21. PTHR11409:SF21. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. Aden_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ADE_RHIEC

Accession

Primary (citable) accession number: Q2KDR5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program