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Q2KD95

- TRMB_RHIEC

UniProt

Q2KD95 - TRMB_RHIEC

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, RHE_CH00369
Organism
Rhizobium etli (strain CFN 42 / ATCC 51251)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei61 – 611S-adenosyl-L-methionine By similarity
Binding sitei86 – 861S-adenosyl-L-methionine By similarity
Binding sitei113 – 1131S-adenosyl-L-methionine By similarity
Active sitei135 – 1351 By similarity
Binding sitei135 – 1351S-adenosyl-L-methionine By similarity
Binding sitei139 – 1391Substrate By similarity
Binding sitei171 – 1711Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciRETL347834:GJJ0-371-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferase
    tRNA(m7G46)-methyltransferase
    Gene namesi
    Name:trmB
    Ordered Locus Names:RHE_CH00369
    OrganismiRhizobium etli (strain CFN 42 / ATCC 51251)
    Taxonomic identifieri347834 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
    ProteomesiUP000001936: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 230230tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
    PRO_0000288209Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi347834.RHE_CH00369.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2KD95.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni209 – 2124Substrate binding By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073969.
    KOiK03439.
    OMAiRAFYGRR.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2KD95-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERRGRATEA FFGRRKGKAL REQQAETLNS LLPAFLIDLS AAPPEPLTSL    50
    FPVPVTTLRL EIGFGGGEHL IHRALERPST GFIGVEPFVN SMQKLLARAG 100
    QTGARNIRVY NDDATQLLDW LPDASLDQID LLYPDPWPKR KHWKRRFVSK 150
    TNLDRFHRVL KPGGLFCFAS DIDTYVNWTL LKCRDHSGFD WIADNAADWL 200
    TPYEGWPSTR YEAKARREGR SSAYLTFRKI 230
    Length:230
    Mass (Da):26,332
    Last modified:March 7, 2006 - v1
    Checksum:i75072252C34CD814
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000133 Genomic DNA. Translation: ABC89191.1.
    RefSeqiYP_467918.1. NC_007761.1.

    Genome annotation databases

    EnsemblBacteriaiABC89191; ABC89191; RHE_CH00369.
    GeneIDi3891139.
    KEGGiret:RHE_CH00369.
    PATRICi23082036. VBIRhiEtl108884_0702.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000133 Genomic DNA. Translation: ABC89191.1 .
    RefSeqi YP_467918.1. NC_007761.1.

    3D structure databases

    ProteinModelPortali Q2KD95.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 347834.RHE_CH00369.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC89191 ; ABC89191 ; RHE_CH00369 .
    GeneIDi 3891139.
    KEGGi ret:RHE_CH00369.
    PATRICi 23082036. VBIRhiEtl108884_0702.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073969.
    KOi K03439.
    OMAi RAFYGRR.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci RETL347834:GJJ0-371-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CFN 42 / ATCC 51251.

    Entry informationi

    Entry nameiTRMB_RHIEC
    AccessioniPrimary (citable) accession number: Q2KD95
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: March 7, 2006
    Last modified: June 11, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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