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Q2KD95

- TRMB_RHIEC

UniProt

Q2KD95 - TRMB_RHIEC

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Rhizobium etli (strain CFN 42 / ATCC 51251)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei61 – 611S-adenosyl-L-methionineUniRule annotation
Binding sitei86 – 861S-adenosyl-L-methionineUniRule annotation
Binding sitei113 – 1131S-adenosyl-L-methionineUniRule annotation
Active sitei135 – 1351By similarity
Binding sitei135 – 1351S-adenosyl-L-methionineUniRule annotation
Binding sitei139 – 1391SubstrateUniRule annotation
Binding sitei171 – 1711SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciRETL347834:GJJ0-371-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:RHE_CH00369
OrganismiRhizobium etli (strain CFN 42 / ATCC 51251)
Taxonomic identifieri347834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
ProteomesiUP000001936: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 230230tRNA (guanine-N(7)-)-methyltransferasePRO_0000288209Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi347834.RHE_CH00369.

Structurei

3D structure databases

ProteinModelPortaliQ2KD95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni209 – 2124Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073969.
KOiK03439.
OMAiRAFYGRR.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2KD95-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERRGRATEA FFGRRKGKAL REQQAETLNS LLPAFLIDLS AAPPEPLTSL
60 70 80 90 100
FPVPVTTLRL EIGFGGGEHL IHRALERPST GFIGVEPFVN SMQKLLARAG
110 120 130 140 150
QTGARNIRVY NDDATQLLDW LPDASLDQID LLYPDPWPKR KHWKRRFVSK
160 170 180 190 200
TNLDRFHRVL KPGGLFCFAS DIDTYVNWTL LKCRDHSGFD WIADNAADWL
210 220 230
TPYEGWPSTR YEAKARREGR SSAYLTFRKI
Length:230
Mass (Da):26,332
Last modified:March 7, 2006 - v1
Checksum:i75072252C34CD814
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000133 Genomic DNA. Translation: ABC89191.1.
RefSeqiWP_011423751.1. NC_007761.1.
YP_467918.1. NC_007761.1.

Genome annotation databases

EnsemblBacteriaiABC89191; ABC89191; RHE_CH00369.
GeneIDi3891139.
KEGGiret:RHE_CH00369.
PATRICi23082036. VBIRhiEtl108884_0702.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000133 Genomic DNA. Translation: ABC89191.1 .
RefSeqi WP_011423751.1. NC_007761.1.
YP_467918.1. NC_007761.1.

3D structure databases

ProteinModelPortali Q2KD95.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 347834.RHE_CH00369.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC89191 ; ABC89191 ; RHE_CH00369 .
GeneIDi 3891139.
KEGGi ret:RHE_CH00369.
PATRICi 23082036. VBIRhiEtl108884_0702.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073969.
KOi K03439.
OMAi RAFYGRR.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci RETL347834:GJJ0-371-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CFN 42 / ATCC 51251.

Entry informationi

Entry nameiTRMB_RHIEC
AccessioniPrimary (citable) accession number: Q2KD95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 7, 2006
Last modified: November 26, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3