Q2KB43 (BETA_RHIEC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Choline dehydrogenase
Short name=CDH
Short name=CHD
EC=1.1.99.1

Gene names

Name:	betA
Ordered Locus Names:	RHE_CH01136

Organism

Rhizobium etli (strain CFN 42 / ATCC 51251) [Complete proteome] [HAMAP]

Taxonomic identifier

347834 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Rhizobium

Protein attributes

Sequence length	549 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity. HAMAP MF_00750
Catalytic activity	Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP MF_00750
Cofactor	FAD By similarity. HAMAP MF_00750
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP MF_00750
Sequence similarities	Belongs to the GMC oxidoreductase family.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: InterPro
Molecular function	choline dehydrogenase activity Inferred from electronic annotation. Source: EC flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 549	549	Choline dehydrogenase HAMAP MF_00750		PRO_0000258932
Regions
	Nucleotide binding	4 – 33	30	FAD Potential
Sites
	Active site	465	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2KB43 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: C262E284AEAB953F	FASTA	549	60,398
	10 20 30 40 50 60 MQADFVIIGS GSAGSALAYR LSEDGKNSVL VIEAGGSDFG PFIQMPAALA WPMSMKRYNW 70 80 90 100 110 120 GYLSEPEPNL NNRRITAPRG KVIGGSSSIN GMVYVRGHAE DFNRWEELGA SGWAYADVLP 130 140 150 160 170 180 YFKRMEHSHG GEEGWRGTDG PLHVQRGGFT NPLFRAFIEA GKQAGFETTE DYNGSKQEGF 190 200 210 220 230 240 GLMEQTIFAG RRWSAANAYL KPALKRDNVG IVYGLARRIV IENGRATGVE IERGGRTEVV 250 260 270 280 290 300 KANREVIVSA SSFNSPKLLM LSGIGPAKHL KEMGIEVKAD RPGVGANLQD HMEFYFQQVS 310 320 330 340 350 360 TKPVSLYSWL PWFWQGVAGA QWLLSKGGLG ASNQFEACAF LRSAPGLKQP DIQYHFLPVA 370 380 390 400 410 420 ISYDGKAAAK SHGFQVHVGY NLSKSRGSVT LRSPDPKADP VLRFNYMSHP EDWEKFRHCV 430 440 450 460 470 480 RLTREIFGQK AFDAYRGPEI QPGEGVQSDE QIDSFLREHL ESAYHPCGTC KMGAKDDPMA 490 500 510 520 530 540 VVDPQTRVIG VDGLRVADSS IFPHVTYGNL NGPSIMTGEK AADHILGKQP LARSNQEPWI NPRAAVSDR

References

[1]

"The partitioned Rhizobium etli genome: genetic and metabolic redundancy in seven interacting replicons." Gonzalez V., Santamaria R.I., Bustos P., Hernandez-Gonzalez I., Medrano-Soto A., Moreno-Hagelsieb G., Janga S.C., Ramirez M.A., Jimenez-Jacinto V., Collado-Vides J., Davila G. Proc. Natl. Acad. Sci. U.S.A. 103:3834-3839(2006) [PubMed: 16505379] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CFN 42 / ATCC 51251.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000133 Genomic DNA. Translation: ABC89943.1.
RefSeq	YP_468670.1. NC_007761.1.
3D structure databases
ProteinModelPortal	Q2KB43.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2KB43.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3890646.
GenomeReviews	Gene locus RHE_CH01136 in contig CP000133_GR.
KEGG	ret:RHE_CH01136.
PATRIC	23083617. VBIRhiEtl108884_1482.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2303.
HOGENOM	HBG734713.
OMA	GPFIQMP.
PhylomeDB	Q2KB43.
ProtClustDB	PRK02106.
Family and domain databases
HAMAP	MF_00750. Choline_dehydrogen. [Tree]
InterPro	IPR011533. Choline_dehydrogenase. IPR012132. GMC_OxRdtase. IPR000172. GMC_OxRdtase_N. IPR007867. GMC_OxRtase_C. [Graphical view]
KO	K00108.
Pfam	PF05199. GMC_oxred_C. 1 hit. PF00732. GMC_oxred_N. 1 hit. [Graphical view]
PIRSF	PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMs	TIGR01810. BetA. 1 hit.
PROSITE	PS00623. GMC_OXRED_1. 1 hit. PS00624. GMC_OXRED_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETA_RHIEC

Accession

Primary (citable) accession number: Q2KB43

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program