ID   BETB_RHIEC              Reviewed;         487 AA.
AC   Q2KB42;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=Betaine aldehyde dehydrogenase;
DE            Short=BADH;
DE            EC=1.2.1.8;
GN   Name=betB; OrderedLocusNames=RHE_CH01137;
OS   Rhizobium etli (strain CFN 42 / ATCC 51251).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=347834;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16505379; DOI=10.1073/pnas.0508502103;
RA   Gonzalez V., Santamaria R.I., Bustos P., Hernandez-Gonzalez I.,
RA   Medrano-Soto A., Moreno-Hagelsieb G., Janga S.C., Ramirez M.A.,
RA   Jimenez-Jacinto V., Collado-Vides J., Davila G.;
RT   "The partitioned Rhizobium etli genome: genetic and metabolic
RT   redundancy in seven interacting replicons.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:3834-3839(2006).
CC   -!- CATALYTIC ACTIVITY: Betaine aldehyde + NAD(+) + H(2)O = betaine +
CC       NADH.
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway; betaine from betaine aldehyde: step 1/1.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; CP000133; ABC89944.1; -; Genomic_DNA.
DR   RefSeq; YP_468671.1; -.
DR   GeneID; 3890791; -.
DR   GenomeReviews; CP000133_GR; RHE_CH01137.
DR   KEGG; ret:RHE_CH01137; -.
DR   HOGENOM; Q2KB42; -.
DR   OMA; Q2KB42; VFKPSEN.
DR   GO; GO:0008802; F:betaine-aldehyde dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from c...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00804; -; 1.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   InterPro; IPR011264; Betaine_Ald_DH.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   TIGRFAMs; TIGR01804; BADH; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    487       Betaine aldehyde dehydrogenase.
FT                                /FTId=PRO_1000047052.
FT   NP_BIND     228    233       NAD (By similarity).
FT   ACT_SITE    250    250       By similarity.
FT   ACT_SITE    284    284       By similarity.
SQ   SEQUENCE   487 AA;  51733 MW;  E1BDD8086ADCBB1C CRC64;
     MKAQPKASHF INGEYVEDTD GTVIESLYPA TGEVIARLHA ATPAIVEKAI AAAKRAQPEW
     AAMSPMARGR ILKRAADIMR ERNRELSELE TLDTGKPIQE TIVADPTSGA DAFEFFGGVA
     PAGLNGSHIP LGQDFAYTKR VPLGVCVGIG AWNYPQQIAC WKGAPALISG NAMVFKPSEN
     TPLGALKIAE ILHEAGLPKG LFNVIQGDRD TGPLLVNHPD VAKVSLTGSV PTGRRVAAAA
     AGSLKHVTME LGGKSPLIVF DDADLDSAVG GAMLGNFYST GQVCSNGTRV FVQKAVKAEF
     LKRLKARTEA MLIGDPLDEA TQIGPMVSWA QREKVIAYIE KGKAEGATLV AGGGIPNNVS
     GEGYYVQPTV FADVTDDMTI AREEIFGPVM SVLDFDDEDE VITRANASEF GLSGGVFTAD
     LSRAHRVVDR LEAGTLWINT YNLCPVEIPF GGSKQSGFGR ENSLAALEHY SELKTVYVGM
     GPVAAPY
//