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Q2KB42

- BETB_RHIEC

UniProt

Q2KB42 - BETB_RHIEC

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Protein
NAD/NADP-dependent betaine aldehyde dehydrogenase
Gene
betB, RHE_CH01137
Organism
Rhizobium etli (strain CFN 42 / ATCC 51251)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid By similarity.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

Binds 2 potassium ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi26 – 261Potassium 1 By similarity
Metal bindingi93 – 931Potassium 1 By similarity
Active sitei162 – 1621Charge relay system By similarity
Metal bindingi244 – 2441Potassium 2; via carbonyl oxygen By similarity
Active sitei250 – 2501Proton acceptor By similarity
Binding sitei284 – 2841NAD/NADP By similarity
Binding sitei384 – 3841NAD/NADP By similarity
Metal bindingi454 – 4541Potassium 2; via carbonyl oxygen By similarity
Metal bindingi457 – 4571Potassium 2; via carbonyl oxygen By similarity
Active sitei461 – 4611Charge relay system By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi150 – 1534NAD/NADP By similarity
Nucleotide bindingi176 – 1794NAD/NADP By similarity
Nucleotide bindingi228 – 2336NAD/NADP By similarity

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

BioCyciRETL347834:GJJ0-1146-MONOMER.
UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betB
Ordered Locus Names:RHE_CH01137
OrganismiRhizobium etli (strain CFN 42 / ATCC 51251)
Taxonomic identifieri347834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
ProteomesiUP000001936: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 487487NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation
PRO_1000047052Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei284 – 2841Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Dimer of dimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi347834.RHE_CH01137.

Structurei

3D structure databases

ProteinModelPortaliQ2KB42.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00130.
OMAiPTQIACW.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00804. BADH.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01804. BADH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2KB42-1 [UniParc]FASTAAdd to Basket

« Hide

MKAQPKASHF INGEYVEDTD GTVIESLYPA TGEVIARLHA ATPAIVEKAI    50
AAAKRAQPEW AAMSPMARGR ILKRAADIMR ERNRELSELE TLDTGKPIQE 100
TIVADPTSGA DAFEFFGGVA PAGLNGSHIP LGQDFAYTKR VPLGVCVGIG 150
AWNYPQQIAC WKGAPALISG NAMVFKPSEN TPLGALKIAE ILHEAGLPKG 200
LFNVIQGDRD TGPLLVNHPD VAKVSLTGSV PTGRRVAAAA AGSLKHVTME 250
LGGKSPLIVF DDADLDSAVG GAMLGNFYST GQVCSNGTRV FVQKAVKAEF 300
LKRLKARTEA MLIGDPLDEA TQIGPMVSWA QREKVIAYIE KGKAEGATLV 350
AGGGIPNNVS GEGYYVQPTV FADVTDDMTI AREEIFGPVM SVLDFDDEDE 400
VITRANASEF GLSGGVFTAD LSRAHRVVDR LEAGTLWINT YNLCPVEIPF 450
GGSKQSGFGR ENSLAALEHY SELKTVYVGM GPVAAPY 487
Length:487
Mass (Da):51,733
Last modified:March 7, 2006 - v1
Checksum:iE1BDD8086ADCBB1C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000133 Genomic DNA. Translation: ABC89944.1.
RefSeqiYP_468671.1. NC_007761.1.

Genome annotation databases

EnsemblBacteriaiABC89944; ABC89944; RHE_CH01137.
GeneIDi3890791.
KEGGiret:RHE_CH01137.
PATRICi23083619. VBIRhiEtl108884_1483.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000133 Genomic DNA. Translation: ABC89944.1 .
RefSeqi YP_468671.1. NC_007761.1.

3D structure databases

ProteinModelPortali Q2KB42.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 347834.RHE_CH01137.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC89944 ; ABC89944 ; RHE_CH01137 .
GeneIDi 3890791.
KEGGi ret:RHE_CH01137.
PATRICi 23083619. VBIRhiEtl108884_1483.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
KOi K00130.
OMAi PTQIACW.
OrthoDBi EOG6BS8QW.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00386 .
BioCyci RETL347834:GJJ0-1146-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPi MF_00804. BADH.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR01804. BADH. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CFN 42 / ATCC 51251.

Entry informationi

Entry nameiBETB_RHIEC
AccessioniPrimary (citable) accession number: Q2KB42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 7, 2006
Last modified: June 11, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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