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Q2KB42 (BETB_RHIEC) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betB
Ordered Locus Names:RHE_CH01137
OrganismRhizobium etli (strain CFN 42 / ATCC 51251) [Complete proteome] [HAMAP]
Taxonomic identifier347834 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Rhizobium

Protein attributes

Sequence length487 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP MF_00804

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP MF_00804

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processbetaine biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionbetaine-aldehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 487487Betaine aldehyde dehydrogenase HAMAP MF_00804
PRO_1000047052

Regions

Nucleotide binding228 – 2336NAD By similarity

Sites

Active site2501 By similarity
Active site2841 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2KB42 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: E1BDD8086ADCBB1C

FASTA48751,733
        10         20         30         40         50         60 
MKAQPKASHF INGEYVEDTD GTVIESLYPA TGEVIARLHA ATPAIVEKAI AAAKRAQPEW 

        70         80         90        100        110        120 
AAMSPMARGR ILKRAADIMR ERNRELSELE TLDTGKPIQE TIVADPTSGA DAFEFFGGVA 

       130        140        150        160        170        180 
PAGLNGSHIP LGQDFAYTKR VPLGVCVGIG AWNYPQQIAC WKGAPALISG NAMVFKPSEN 

       190        200        210        220        230        240 
TPLGALKIAE ILHEAGLPKG LFNVIQGDRD TGPLLVNHPD VAKVSLTGSV PTGRRVAAAA 

       250        260        270        280        290        300 
AGSLKHVTME LGGKSPLIVF DDADLDSAVG GAMLGNFYST GQVCSNGTRV FVQKAVKAEF 

       310        320        330        340        350        360 
LKRLKARTEA MLIGDPLDEA TQIGPMVSWA QREKVIAYIE KGKAEGATLV AGGGIPNNVS 

       370        380        390        400        410        420 
GEGYYVQPTV FADVTDDMTI AREEIFGPVM SVLDFDDEDE VITRANASEF GLSGGVFTAD 

       430        440        450        460        470        480 
LSRAHRVVDR LEAGTLWINT YNLCPVEIPF GGSKQSGFGR ENSLAALEHY SELKTVYVGM 


GPVAAPY

« Hide

References

[1]"The partitioned Rhizobium etli genome: genetic and metabolic redundancy in seven interacting replicons."
Gonzalez V., Santamaria R.I., Bustos P., Hernandez-Gonzalez I., Medrano-Soto A., Moreno-Hagelsieb G., Janga S.C., Ramirez M.A., Jimenez-Jacinto V., Collado-Vides J., Davila G.
Proc. Natl. Acad. Sci. U.S.A. 103:3834-3839(2006) [PubMed: 16505379] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CFN 42 / ATCC 51251.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000133 Genomic DNA. Translation: ABC89944.1.
RefSeqYP_468671.1. NC_007761.1.

3D structure databases

HSSPHSSP built from PDB template 2D4E based on UniProtKB Q5SJP9.
ProteinModelPortalQ2KB42.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2KB42.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3890791.
GenomeReviewsGene locus RHE_CH01137 in contig CP000133_GR.
KEGGret:RHE_CH01137.
PATRIC23083619. VBIRhiEtl108884_1483.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHBG752218.
OMAIMRERNR.
PhylomeDBQ2KB42.
ProtClustDBPRK13252.

Family and domain databases

HAMAPMF_00804. BADH.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. Betaine_Ald_DH.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK00130.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR01804. BADH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETB_RHIEC
AccessionPrimary (citable) accession number: Q2KB42
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 7, 2006
Last modified: January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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