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Protein

Alanine racemase

Gene

alr

Organism
Rhizobium etli (strain CFN 42 / ATCC 51251)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (dadX), Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei92SubstrateUniRule annotation1
Active sitei214Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei273Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:RHE_CH01432Imported
OrganismiRhizobium etli (strain CFN 42 / ATCC 51251)Imported
Taxonomic identifieri347834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
Proteomesi
  • UP000001936 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi347834.RHE_CH01432

Structurei

3D structure databases

ProteinModelPortaliQ2KAA1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini193 – 330Ala_racemase_CInterPro annotationAdd BLAST138

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031445
KOiK01775
OMAiCALHVDT

Family and domain databases

Gene3Di2.40.37.10, 1 hit
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit

Sequencei

Sequence statusi: Complete.

Q2KAA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIEDAGEAL YLAGARDFFV ATVDEGVTLR LYAPEARIFV LSGIWPGTER
60 70 80 90 100
RFFDNDLVPV ISSDEQFAFW MAVLADYGDY PCALHVDTGF NRLGLHIDDA
110 120 130 140 150
IALADDVSRP ASFAPVLVMS HLACGDDPSH LMNRQQLESF RKVTAAYEGI
160 170 180 190 200
DSSLAASAGI FLGEDYHFDL TRPGIALYGG EAVCGVTNPM RPVATTEARI
210 220 230 240 250
IQVRTVKAGE TVSYGRALQL HRDSRLAIVS AGYADGYMRS QSSGGVPLRQ
260 270 280 290 300
AVPQGGQGFI AGHKVPVAGR ITMDLTIFDV TDLPENAVRA GDYVELFGKN
310 320 330
MALDDVARAA GTIGYEILTS MGLRHERRYV AEE
Length:333
Mass (Da):36,045
Last modified:March 7, 2006 - v1
Checksum:i06264F49BC1F36E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000133 Genomic DNA Translation: ABC90235.1

Genome annotation databases

EnsemblBacteriaiABC90235; ABC90235; RHE_CH01432
KEGGiret:RHE_CH01432

Similar proteinsi

Entry informationi

Entry nameiQ2KAA1_RHIEC
AccessioniPrimary (citable) accession number: Q2KAA1
Entry historyiIntegrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health