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Q2KA01 (Q2KA01_RHIEC) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III HAMAP MF_01815
Beta-ketoacyl-ACP synthase III HAMAP MF_01815
Gene names
Name:fabH HAMAP MF_01815 EMBL ABC90335.1
Ordered Locus Names:RHE_CH01532
OrganismRhizobium etli (strain CFN 42 / ATCC 51251) [Complete proteome] [HAMAP]
Taxonomic identifier347834 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Rhizobium

Protein attributes

Sequence length301 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region229 – 2335ACP-binding By similarity HAMAP MF_01815

Sites

Active site911 By similarity HAMAP MF_01815
Active site2281 By similarity HAMAP MF_01815
Active site2581 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
Q2KA01 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: 3ECBFF5BBBBEBF5F

FASTA30131,669
        10         20         30         40         50         60 
MEAIVDTSDE WIVQRTGIRQ RHVAGDDETT ASLGEAAARA ALANGGLMPA DIDLIICATS 

        70         80         90        100        110        120 
TPDNTFPATS VNIQNRLGMS HGFAFDVQAV CTGFVYAVTT ADAYIRGGLA KRVLVIGAET 

       130        140        150        160        170        180 
FSRILDWNDR TTCVLFGDGA GAIVLEAAEG EGTSADRGVL TAHLRSDGSH KDKLYVDGGP 

       190        200        210        220        230        240 
STTGSVGKLR MEGREVFKYA VGMITDVIQA AFDSTGTTAE DLDWLVPHQA NRRIIDGSAK 

       250        260        270        280        290        300 
KLNIDADKVV VTVDLHGNTS AASIPLALAT AAGDGRIKKG DLVMLEAMGG GFTWGAVLLR 


W

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References

[1]"The partitioned Rhizobium etli genome: genetic and metabolic redundancy in seven interacting replicons."
Gonzalez V., Santamaria R.I., Bustos P., Hernandez-Gonzalez I., Medrano-Soto A., Moreno-Hagelsieb G., Janga S.C., Ramirez M.A., Jimenez-Jacinto V., Collado-Vides J., Davila G.
Proc. Natl. Acad. Sci. U.S.A. 103:3834-3839(2006) [PubMed: 16505379] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000133 Genomic DNA. Translation: ABC90335.1.
RefSeqYP_469062.2. NC_007761.1.

3D structure databases

ProteinModelPortalQ2KA01.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2KA01.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3890835.
GenomeReviewsGene locus RHE_CH01532 in contig CP000133_GR.
KEGGret:RHE_CH01532.
PATRIC23084483. VBIRhiEtl108884_1913.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0332.
HOGENOMHBG649927.
OMADAYIRGG.
PhylomeDBQ2KA01.
ProtClustDBPRK09352.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ2KA01_RHIEC
AccessionPrimary (citable) accession number: Q2KA01
Entry history
Integrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: December 14, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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