ID   HGD_RHIEC               Reviewed;         453 AA.
AC   Q2K9E5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   05-MAY-2009, entry version 21.
DE   RecName: Full=Homogentisate 1,2-dioxygenase;
DE            EC=1.13.11.5;
DE   AltName: Full=Homogentisicase;
DE   AltName: Full=Homogentisate oxygenase;
DE   AltName: Full=Homogentisic acid oxidase;
GN   Name=hmgA; OrderedLocusNames=RHE_CH01746;
OS   Rhizobium etli (strain CFN 42 / ATCC 51251).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=347834;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16505379; DOI=10.1073/pnas.0508502103;
RA   Gonzalez V., Santamaria R.I., Bustos P., Hernandez-Gonzalez I.,
RA   Medrano-Soto A., Moreno-Hagelsieb G., Janga S.C., Ramirez M.A.,
RA   Jimenez-Jacinto V., Collado-Vides J., Davila G.;
RT   "The partitioned Rhizobium etli genome: genetic and metabolic
RT   redundancy in seven interacting replicons.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:3834-3839(2006).
CC   -!- CATALYTIC ACTIVITY: Homogentisate + O(2) = 4-maleylacetoacetate.
CC   -!- COFACTOR: Iron (By similarity).
CC   -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC       acetoacetic acid and fumarate from L-phenylalanine: step 4/6.
CC   -!- SIMILARITY: Belongs to the homogentisate dioxygenase family.
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DR   EMBL; CP000133; ABC90541.1; -; Genomic_DNA.
DR   RefSeq; YP_469268.1; -.
DR   GeneID; 3894193; -.
DR   GenomeReviews; CP000133_GR; RHE_CH01746.
DR   KEGG; ret:RHE_CH01746; -.
DR   HOGENOM; Q2K9E5; -.
DR   OMA; Q2K9E5; HRNCMSE.
DR   GO; GO:0004411; F:homogentisate 1,2-dioxygenase activity; IEA:HAMAP.
DR   GO; GO:0005506; F:iron ion binding; IEA:HAMAP.
DR   GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006572; P:tyrosine catabolic process; IEA:HAMAP.
DR   HAMAP; MF_00334; -; 1.
DR   InterPro; IPR005708; Homogentis_dOase.
DR   PANTHER; PTHR11056; Homogentis_dOase; 1.
DR   Pfam; PF04209; HgmA; 1.
DR   TIGRFAMs; TIGR01015; hmgA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase;
KW   Phenylalanine catabolism; Tyrosine catabolism.
FT   CHAIN         1    453       Homogentisate 1,2-dioxygenase.
FT                                /FTId=PRO_1000019538.
FT   METAL       349    349       Iron (By similarity).
FT   METAL       355    355       Iron (By similarity).
FT   METAL       385    385       Iron (By similarity).
SQ   SEQUENCE   453 AA;  50806 MW;  0148D86F9664C483 CRC64;
     MDQTAIQAAD AEAATANRLK YMPGFGNDFE TESLPGALPQ GQNSPQKCNY GLYAEQLSGS
     PFTAPRGTNE RSWLYRIRPS VRHTRRFSNA SYPLWKTAPC LDEHSLPLGQ LRWDPIPAPE
     EKLTFLQGVR TMTTAGDAAT QVGMSAHAYV FNEDMVDDYF FDADGELLIV PQLGAIRVFT
     EMGIMDVEPL EICLVPRGMM FKVMTTGEQT ASRGYICENY GAKFTLPDRG PIGANCLANP
     RDFKTPVAAF EDKEKPCRVH VKWCGKFYVT EIGHSPLDVV AWHGNYAPYK YDLRTFSPVG
     AISFDHPDPS IFSVLTAPTE DAGTANVDFV IFPPRWLVAE HTFRPPWYHR NIMSEFMGLI
     HGQYDAKEEG FVPGGISLHN MMLPHGPDAL AFEKASNVEL KPVKLDHTMA FMFETRYPQQ
     LTKYAAELET LQDDYLECWD GLERKFDGTP GIK
//