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Q2K9E5

- HGD_RHIEC

UniProt

Q2K9E5 - HGD_RHIEC

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Protein
Homogentisate 1,2-dioxygenase
Gene
hmgA, RHE_CH01746
Organism
Rhizobium etli (strain CFN 42 / ATCC 51251)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate By similarity.UniRule annotation

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

Cofactori

Iron By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei306 – 3061Proton acceptor By similarity
Metal bindingi349 – 3491Iron By similarity
Metal bindingi355 – 3551Iron By similarity
Binding sitei364 – 3641homogentisate By similarity
Metal bindingi385 – 3851Iron By similarity
Binding sitei385 – 3851homogentisate By similarity

GO - Molecular functioni

  1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-HAMAP
  2. iron ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. L-phenylalanine catabolic process Source: UniProtKB-HAMAP
  2. tyrosine catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciRETL347834:GJJ0-1757-MONOMER.
UniPathwayiUPA00139; UER00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenase (EC:1.13.11.5)
Short name:
HGDO
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene namesi
Name:hmgA
Ordered Locus Names:RHE_CH01746
OrganismiRhizobium etli (strain CFN 42 / ATCC 51251)
Taxonomic identifieri347834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
ProteomesiUP000001936: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453Homogentisate 1,2-dioxygenaseUniRule annotation
PRO_1000019538Add
BLAST

Interactioni

Subunit structurei

Hexamer; dimer of trimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi347834.RHE_CH01746.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3508.
HOGENOMiHOG000139824.
KOiK00451.
OMAiTTETHKL.
OrthoDBiEOG6D5FZK.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_00334. Homogentis_dioxygen.
InterProiIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2K9E5-1 [UniParc]FASTAAdd to Basket

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MDQTAIQAAD AEAATANRLK YMPGFGNDFE TESLPGALPQ GQNSPQKCNY    50
GLYAEQLSGS PFTAPRGTNE RSWLYRIRPS VRHTRRFSNA SYPLWKTAPC 100
LDEHSLPLGQ LRWDPIPAPE EKLTFLQGVR TMTTAGDAAT QVGMSAHAYV 150
FNEDMVDDYF FDADGELLIV PQLGAIRVFT EMGIMDVEPL EICLVPRGMM 200
FKVMTTGEQT ASRGYICENY GAKFTLPDRG PIGANCLANP RDFKTPVAAF 250
EDKEKPCRVH VKWCGKFYVT EIGHSPLDVV AWHGNYAPYK YDLRTFSPVG 300
AISFDHPDPS IFSVLTAPTE DAGTANVDFV IFPPRWLVAE HTFRPPWYHR 350
NIMSEFMGLI HGQYDAKEEG FVPGGISLHN MMLPHGPDAL AFEKASNVEL 400
KPVKLDHTMA FMFETRYPQQ LTKYAAELET LQDDYLECWD GLERKFDGTP 450
GIK 453
Length:453
Mass (Da):50,806
Last modified:March 7, 2006 - v1
Checksum:i0148D86F9664C483
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000133 Genomic DNA. Translation: ABC90541.1.
RefSeqiWP_011425039.1. NC_007761.1.
YP_469268.1. NC_007761.1.

Genome annotation databases

EnsemblBacteriaiABC90541; ABC90541; RHE_CH01746.
GeneIDi3894193.
KEGGiret:RHE_CH01746.
PATRICi23084955. VBIRhiEtl108884_2141.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000133 Genomic DNA. Translation: ABC90541.1 .
RefSeqi WP_011425039.1. NC_007761.1.
YP_469268.1. NC_007761.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 347834.RHE_CH01746.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC90541 ; ABC90541 ; RHE_CH01746 .
GeneIDi 3894193.
KEGGi ret:RHE_CH01746.
PATRICi 23084955. VBIRhiEtl108884_2141.

Phylogenomic databases

eggNOGi COG3508.
HOGENOMi HOG000139824.
KOi K00451.
OMAi TTETHKL.
OrthoDBi EOG6D5FZK.

Enzyme and pathway databases

UniPathwayi UPA00139 ; UER00339 .
BioCyci RETL347834:GJJ0-1757-MONOMER.

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
HAMAPi MF_00334. Homogentis_dioxygen.
InterProi IPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR11056. PTHR11056. 1 hit.
Pfami PF04209. HgmA. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR01015. hmgA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CFN 42 / ATCC 51251.

Entry informationi

Entry nameiHGD_RHIEC
AccessioniPrimary (citable) accession number: Q2K9E5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 7, 2006
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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