Q2K8E2 (Q2K8E2_RHIEC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897

Gene names

Name:	gyrA HAMAP MF_01897 EMBL ABC90894.1
Ordered Locus Names:	RHE_CH02110

Organism

Rhizobium etli (strain CFN 42 / ATCC 51251) [Complete proteome] [HAMAP]

Taxonomic identifier

347834 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Rhizobium

Protein attributes

Sequence length	908 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691 HAMAP MF_01897
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP MF_01897
Subunit structure	Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897
Subcellular location	Cytoplasm By similarity SAAS SAAS006691 HAMAP MF_01897.
Sequence similarities	Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Ontologies

Keywords
Cellular component	Cytoplasm SAAS SAAS006691 HAMAP MF_01897
Ligand	ATP-binding SAAS SAAS006691 HAMAP MF_01897 DNA-binding SAAS SAAS006691 HAMAP MF_01897 Nucleotide-binding
Molecular function	Isomerase Topoisomerase SAAS SAAS006691 HAMAP MF_01897
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q2K8E2 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 9076829FB9176A27	FASTA	908	100,517
	10 20 30 40 50 60 MSVIVSRALP DVRDGLKPVH RRILYGMSEL GIDWNKKYVK CARVTGDVMG KYHPHGNAAI 70 80 90 100 110 120 YDALARMAQP WSLRLPLIDG QGNFGSVDGD PPAAERYTEC RLEKAAHSLL DDLDKETVDF 130 140 150 160 170 180 RDNYDGTLSE PVVVPAKFPN LLVNGAGGIA VGMATNIPPH NLSEVIDGCI ALINDPAIEL 190 200 210 220 230 240 PELMQIIPGP DFPTGAKILG RAGIRSAYET GRGSVIMRGV ATIEPMRGDR EQIIITEIPY 250 260 270 280 290 300 QVNKATMIEK MAELVREKRI EGISDLRDES DRQGYRVVIE LKRDANAEVI LNQLYRYTPL 310 320 330 340 350 360 QTSFGCNMVA LNGGKPEQLT LLDMLRAFVS FREEVVSRRT KFLLRKARER AHVLVGLAIA 370 380 390 400 410 420 VANIDEVIRV IRQAPDPQSA REELMTRRWP AEDVESLIRL IDDPRHRIND DLTYNLSEEQ 430 440 450 460 470 480 ARAILELRLA RLTALGRDEI GDELNKIGEE IRDYLDILSS RVRIQTIVKD ELSAVRDEFG 490 500 510 520 530 540 TPRRTEIVDG GLEMDDEDLI AREDMVVTVS HLGYIKRVPL TTYRAQRRGG KGRSGMTTRD 550 560 570 580 590 600 EDFVSRLFVV NTHTPVLFFS SRGIVYKEKV WRLPIGTPTS RGKALINMLP LEPGERITTI 610 620 630 640 650 660 LPLPEDEASW DNLDVMFSTT RGTVRRNKLS DFVQVNRNGK IAMKLEEEGD EILSVETCTD 670 680 690 700 710 720 RDDVLLTTAL GQCIRFSVDD VRVFAGRNSI GVRGINLGEG DRIISMTIVG HVDAEPWERA 730 740 750 760 770 780 AYLKRSAAER RAIGVDEEDI ALVGEEVTEE GQLSDERYEE LKAREQFVLT VSEKGFGKRS 790 800 810 820 830 840 SSYDFRISGR GGKGIRATDT SKTGEIGELV AAFPVDDGDQ IMLVSDGGQL IRVPVGGIRI 850 860 870 880 890 900 ASRATKGVTI FSTAKDEKVV SVERISEPEE DDTEGAVDAA EAAAGADETP FADETPVADG DPGGAAEE

References

[1]

"The partitioned Rhizobium etli genome: genetic and metabolic redundancy in seven interacting replicons." Gonzalez V., Santamaria R.I., Bustos P., Hernandez-Gonzalez I., Medrano-Soto A., Moreno-Hagelsieb G., Janga S.C., Ramirez M.A., Jimenez-Jacinto V., Collado-Vides J., Davila G. Proc. Natl. Acad. Sci. U.S.A. 103:3834-3839(2006) [PubMed: 16505379] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000133 Genomic DNA. Translation: ABC90894.1.
RefSeq	YP_469621.2. NC_007761.1.
3D structure databases
ProteinModelPortal	Q2K8E2.
SMR	Q2K8E2. Positions 5-488.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2K8E2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3893753.
GenomeReviews	Gene locus RHE_CH02110 in contig CP000133_GR.
KEGG	ret:RHE_CH02110.
PATRIC	23085720. VBIRhiEtl108884_2515.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0188.
HOGENOM	HBG635183.
OMA	TSIPPHR.
PhylomeDB	Q2K8E2.
ProtClustDB	PRK05560.
Family and domain databases
HAMAP	MF_01897. GyrA. [Tree]
InterPro	IPR005743. GyrA. IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013757. Topo_IIA_A_a. IPR013760. Topo_IIA_cen. [Graphical view]
Gene3D	G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit. G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KO	K02469.
Pfam	PF03989. DNA_gyraseA_C. 6 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view]
SMART	SM00434. TOP4c. 1 hit. [Graphical view]
SUPFAM	SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMs	TIGR01063. GyrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q2K8E2_RHIEC

Accession

Primary (citable) accession number: Q2K8E2

Entry history

Integrated into UniProtKB/TrEMBL:	March 7, 2006
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)