ID   Q2K8B4_RHIEC            Unreviewed;      1081 AA.
AC   Q2K8B4;
DT   07-MAR-2006, integrated into UniProtKB/TrEMBL.
DT   07-MAR-2006, sequence version 1.
DT   27-MAR-2024, entry version 116.
DE   SubName: Full=Adenylate/guanylate cyclase protein {ECO:0000313|EMBL:ABC90922.1};
GN   OrderedLocusNames=RHE_CH02138 {ECO:0000313|EMBL:ABC90922.1};
OS   Rhizobium etli (strain CFN 42 / ATCC 51251).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=347834 {ECO:0000313|EMBL:ABC90922.1, ECO:0000313|Proteomes:UP000001936};
RN   [1] {ECO:0000313|EMBL:ABC90922.1, ECO:0000313|Proteomes:UP000001936}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFN 42 / ATCC 51251 {ECO:0000313|Proteomes:UP000001936};
RX   PubMed=16505379; DOI=10.1073/pnas.0508502103;
RA   Gonzalez V., Santamaria R.I., Bustos P., Hernandez-Gonzalez I.,
RA   Medrano-Soto A., Moreno-Hagelsieb G., Janga S.C., Ramirez M.A.,
RA   Jimenez-Jacinto V., Collado-Vides J., Davila G.;
RT   "The partitioned Rhizobium etli genome: genetic and metabolic redundancy in
RT   seven interacting replicons.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:3834-3839(2006).
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DR   EMBL; CP000133; ABC90922.1; -; Genomic_DNA.
DR   RefSeq; WP_011425404.1; NC_007761.1.
DR   AlphaFoldDB; Q2K8B4; -.
DR   KEGG; ret:RHE_CH02138; -.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG2888; Bacteria.
DR   eggNOG; COG3899; Bacteria.
DR   HOGENOM; CLU_004435_0_1_5; -.
DR   OrthoDB; 9785312at2; -.
DR   Proteomes; UP000001936; Chromosome.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR025874; DZR.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR16305:SF28; ADENYLATE CYCLASE 10; 1.
DR   PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF12773; DZR; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SMART; SM00028; TPR; 6.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001936};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          78..210
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   1081 AA;  117542 MW;  ED040C560A0B5DC9 CRC64;
     MDCAGCGFDI QSGFAFCPRC GAKQPLSCAA CGYPCQPDFA FCPRCGASIS GKAQPAAKPA
     IETAPAEADS DADRRPVTVL FADLCGFTSL SEQIDPEVMR ALQNELFEEM TLAVEAYGGF
     VDKFVGDALL ALFGAPVAHE DDPVRALNAA LDMIDRAAAV GTRWQSRAGV PLRLHIGINS
     GPVVTGGFGA ASTKSYSVTG DTVNTAQRLQ SMAGENDILV GPLTYRLTRH AFAFESLGAQ
     ALRGKSGNVL VHRLTGLLEA PHTARGLESF GLRAPMVGRD ADMSRLLTCL DLACGGAAQL
     VRLIGEAGIG KSRLASEFVG VAADADRFPG LAIRKATCSP LGEQSYGTLA AVVRSAYGIG
     ERDDRDKTRE LLTTGFRALD LRSDDIDALL PLFLHVLGLG DPDGALRHIE PEQLRRQIFY
     AVRTVFERRL AQGPLLLVIE DLHWADAASL EVLRFMMDRL ERSRLMLLAI YRPTLQTDPL
     NSNRVSVTVQ RLAPLLAADG QKLLAAFFGE GHGKLPAPMR KRILDRAGGN PLFIEEILRG
     LIDMGTLHND GQRWHVAAED ADVDIPVNLQ ALLLARVDRL PQEIRRLAQE AAVVGPKFDT
     ALLRTVATDP AGVDAALDYL CDANIIEELR GPDAAISPGY RFSQTLMHDV AYHNLLLQRR
     MELHRRVGRA LERQYGVAPD RAEHLAQLGH HFSLTTEKAK GASYLMAAGD MARKIYANDD
     AMRLYRQALA AFADEPEMTP EQSALLERLG DLCGPAGQRE AALNHYQRAL ATHRAKDDRI
     AAARILRKIS RLHLEAGRRD QAESRCAEAE AMIAPIDAPI EHAHLLQERG HLAFRTGDQA
     AAVEWATQAL QCLQTLPIDG TTEAGREAAR AMAEALNTKG AALARLGRRR DAVQEVERSL
     SVAEKADLQS AACRAYSNLG VLYTIVDPAN AIRICRRGLE VATRIGDLGF QARLLANLAV
     SCCTFTDRCG AEGVPAAEKA VEIDRALDQR DHLSVPLIVL GQIHQCHGQP KLARKYYEEA
     LEVAKEIDEP QLLFPCYDGL ATLSLEHDDM DEAERYFALA QDVCIRHKLD PGTFVVLPFL
     D
//