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Q2K813 (GCSP_RHIEC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:RHE_CH02243
OrganismRhizobium etli (strain CFN 42 / ATCC 51251) [Complete proteome] [HAMAP]
Taxonomic identifier347834 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium

Protein attributes

Sequence length954 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 954954Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045599

Amino acid modifications

Modified residue7041N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2K813 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: 50338D5932DA1EC8

FASTA954104,034
        10         20         30         40         50         60 
MTTPTEFQFT DYQPYDFANR RHIGPSPAEM AEMLKVIGYN SLEGLIDATL PPAIRQKAPL 

        70         80         90        100        110        120 
VWGAPMTERE ALDKLRETAN KNKVLVSLIG QGYYGTITPP VIQRNILENP AWYTAYTPYQ 

       130        140        150        160        170        180 
PEISQGRLEA LLNYQTMVCD LTGLDIANAS LLDEATAAAE GMAMAERVAK SKAKAFFVDA 

       190        200        210        220        230        240 
DCHPQTIALI RTRAEPLGWS VIVGNPFTDL DPVDVFGAIF QYPGTHGHVH DFTGLIARLH 

       250        260        270        280        290        300 
QAGAISVVAA DILALTLLKS PGEMGADIAV GSSQRFGVPV GYGGPHAAFM AVRDAIKRAM 

       310        320        330        340        350        360 
PGRLVGVSVD ARGNRAYRLS LQTREQHIRR EKATSNICTA QVLLAVMASM YAVFHGPDGI 

       370        380        390        400        410        420 
KAIAQQVHQK AVLMAKGLEK LGYKVEPESF FDTITVDVGH MQGLILRAAV AEGVNLRKVG 

       430        440        450        460        470        480 
ETKIGMSLDE RTRPATLEAV WRAFGGNFTI ADFEPSYRLP KALLRTSEYL SHPIFHMNRA 

       490        500        510        520        530        540 
ESEMTRYIRR LSDRDLALDR AMIPLGSCTM KLNATAEMLP ITWPEFSDIH PFVPADQALG 

       550        560        570        580        590        600 
YREMLDDLTE KLCAVTGYDA FSMQPNSGAQ GEYAGLLTIR NYHIANGEGH RDVCLIPTSA 

       610        620        630        640        650        660 
HGTNPASAQM VGMKVVVVKV RENGDIDMED FRAKAEEHAA NLSCCMITYP STHGVFEETV 

       670        680        690        700        710        720 
KEICELVHKH GGQVYLDGAN MNAMVGLSRP GDIGSDVSHL NLHKTFCIPH GGGGPGMGPI 

       730        740        750        760        770        780 
GVKAHLAPHL PGHPETDGRP GAVSAAPFGS ASILPISWSY CLMMGGEGLT QATKVAILNA 

       790        800        810        820        830        840 
NYIATRLKGA YNVLYKSKTG RVAHECIIDT RPLVDSSGVT VDDVAKRLID CGFHAPTMSW 

       850        860        870        880        890        900 
PVAGTLMIEP TESETKAELD RFCEAMLAIR EEARAIEDGR MDKTNNPLKN APHTVEDLVG 

       910        920        930        940        950 
EWDRPYSREQ ACFPPGAFRV DKYWSPVNRV DNVYGDRNLI CTCPPVESYA EAAE 

« Hide

References

[1]"The partitioned Rhizobium etli genome: genetic and metabolic redundancy in seven interacting replicons."
Gonzalez V., Santamaria R.I., Bustos P., Hernandez-Gonzalez I., Medrano-Soto A., Moreno-Hagelsieb G., Janga S.C., Ramirez M.A., Jimenez-Jacinto V., Collado-Vides J., Davila G.
Proc. Natl. Acad. Sci. U.S.A. 103:3834-3839(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CFN 42 / ATCC 51251.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000133 Genomic DNA. Translation: ABC91023.1.
RefSeqYP_469750.1. NC_007761.1.

3D structure databases

ProteinModelPortalQ2K813.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING347834.RHE_CH02243.

Proteomic databases

PRIDEQ2K813.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABC91023; ABC91023; RHE_CH02243.
GeneID3890670.
KEGGret:RHE_CH02243.
PATRIC23086012. VBIRhiEtl108884_2659.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycRETL347834:GJJ0-2254-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_RHIEC
AccessionPrimary (citable) accession number: Q2K813
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 7, 2006
Last modified: February 19, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families