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Q2K813

- GCSP_RHIEC

UniProt

Q2K813 - GCSP_RHIEC

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, RHE_CH02243
Organism
Rhizobium etli (strain CFN 42 / ATCC 51251)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciRETL347834:GJJ0-2254-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:RHE_CH02243
OrganismiRhizobium etli (strain CFN 42 / ATCC 51251)
Taxonomic identifieri347834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
ProteomesiUP000001936: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 954954Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000045599Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei704 – 7041N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiQ2K813.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi347834.RHE_CH02243.

Structurei

3D structure databases

ProteinModelPortaliQ2K813.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
KOiK00281.
OMAiTAYLTHP.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2K813-1 [UniParc]FASTAAdd to Basket

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MTTPTEFQFT DYQPYDFANR RHIGPSPAEM AEMLKVIGYN SLEGLIDATL    50
PPAIRQKAPL VWGAPMTERE ALDKLRETAN KNKVLVSLIG QGYYGTITPP 100
VIQRNILENP AWYTAYTPYQ PEISQGRLEA LLNYQTMVCD LTGLDIANAS 150
LLDEATAAAE GMAMAERVAK SKAKAFFVDA DCHPQTIALI RTRAEPLGWS 200
VIVGNPFTDL DPVDVFGAIF QYPGTHGHVH DFTGLIARLH QAGAISVVAA 250
DILALTLLKS PGEMGADIAV GSSQRFGVPV GYGGPHAAFM AVRDAIKRAM 300
PGRLVGVSVD ARGNRAYRLS LQTREQHIRR EKATSNICTA QVLLAVMASM 350
YAVFHGPDGI KAIAQQVHQK AVLMAKGLEK LGYKVEPESF FDTITVDVGH 400
MQGLILRAAV AEGVNLRKVG ETKIGMSLDE RTRPATLEAV WRAFGGNFTI 450
ADFEPSYRLP KALLRTSEYL SHPIFHMNRA ESEMTRYIRR LSDRDLALDR 500
AMIPLGSCTM KLNATAEMLP ITWPEFSDIH PFVPADQALG YREMLDDLTE 550
KLCAVTGYDA FSMQPNSGAQ GEYAGLLTIR NYHIANGEGH RDVCLIPTSA 600
HGTNPASAQM VGMKVVVVKV RENGDIDMED FRAKAEEHAA NLSCCMITYP 650
STHGVFEETV KEICELVHKH GGQVYLDGAN MNAMVGLSRP GDIGSDVSHL 700
NLHKTFCIPH GGGGPGMGPI GVKAHLAPHL PGHPETDGRP GAVSAAPFGS 750
ASILPISWSY CLMMGGEGLT QATKVAILNA NYIATRLKGA YNVLYKSKTG 800
RVAHECIIDT RPLVDSSGVT VDDVAKRLID CGFHAPTMSW PVAGTLMIEP 850
TESETKAELD RFCEAMLAIR EEARAIEDGR MDKTNNPLKN APHTVEDLVG 900
EWDRPYSREQ ACFPPGAFRV DKYWSPVNRV DNVYGDRNLI CTCPPVESYA 950
EAAE 954
Length:954
Mass (Da):104,034
Last modified:March 7, 2006 - v1
Checksum:i50338D5932DA1EC8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000133 Genomic DNA. Translation: ABC91023.1.
RefSeqiWP_011425504.1. NC_007761.1.
YP_469750.1. NC_007761.1.

Genome annotation databases

EnsemblBacteriaiABC91023; ABC91023; RHE_CH02243.
GeneIDi3890670.
KEGGiret:RHE_CH02243.
PATRICi23086012. VBIRhiEtl108884_2659.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000133 Genomic DNA. Translation: ABC91023.1 .
RefSeqi WP_011425504.1. NC_007761.1.
YP_469750.1. NC_007761.1.

3D structure databases

ProteinModelPortali Q2K813.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 347834.RHE_CH02243.

Proteomic databases

PRIDEi Q2K813.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC91023 ; ABC91023 ; RHE_CH02243 .
GeneIDi 3890670.
KEGGi ret:RHE_CH02243.
PATRICi 23086012. VBIRhiEtl108884_2659.

Phylogenomic databases

eggNOGi COG1003.
KOi K00281.
OMAi TAYLTHP.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci RETL347834:GJJ0-2254-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CFN 42 / ATCC 51251.

Entry informationi

Entry nameiGCSP_RHIEC
AccessioniPrimary (citable) accession number: Q2K813
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 7, 2006
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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