ID   Q2K6R9_RHIEC            Unreviewed;       656 AA.
AC   Q2K6R9;
DT   07-MAR-2006, integrated into UniProtKB/TrEMBL.
DT   07-MAR-2006, sequence version 1.
DT   27-MAR-2024, entry version 96.
DE   SubName: Full=Adenylate cyclase protein {ECO:0000313|EMBL:ABC91467.1};
DE            EC=4.6.1.1 {ECO:0000313|EMBL:ABC91467.1};
GN   Name=cyaK {ECO:0000313|EMBL:ABC91467.1};
GN   OrderedLocusNames=RHE_CH02696 {ECO:0000313|EMBL:ABC91467.1};
OS   Rhizobium etli (strain CFN 42 / ATCC 51251).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=347834 {ECO:0000313|EMBL:ABC91467.1, ECO:0000313|Proteomes:UP000001936};
RN   [1] {ECO:0000313|EMBL:ABC91467.1, ECO:0000313|Proteomes:UP000001936}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFN 42 / ATCC 51251 {ECO:0000313|Proteomes:UP000001936};
RX   PubMed=16505379; DOI=10.1073/pnas.0508502103;
RA   Gonzalez V., Santamaria R.I., Bustos P., Hernandez-Gonzalez I.,
RA   Medrano-Soto A., Moreno-Hagelsieb G., Janga S.C., Ramirez M.A.,
RA   Jimenez-Jacinto V., Collado-Vides J., Davila G.;
RT   "The partitioned Rhizobium etli genome: genetic and metabolic redundancy in
RT   seven interacting replicons.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:3834-3839(2006).
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DR   EMBL; CP000133; ABC91467.1; -; Genomic_DNA.
DR   RefSeq; WP_011425945.1; NC_007761.1.
DR   AlphaFoldDB; Q2K6R9; -.
DR   KEGG; ret:RHE_CH02696; -.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG4252; Bacteria.
DR   HOGENOM; CLU_000445_85_1_5; -.
DR   OrthoDB; 9789782at2; -.
DR   Proteomes; UP000001936; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR007890; CHASE2.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   PANTHER; PTHR43081:SF1; PH-SENSITIVE ADENYLATE CYCLASE RV1264; 1.
DR   Pfam; PF05226; CHASE2; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM01080; CHASE2; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Lyase {ECO:0000313|EMBL:ABC91467.1}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001936};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        294..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        327..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          412..552
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   656 AA;  70238 MW;  2EC71A00EC60830A CRC64;
     MRVWDKHRQA RQIRGRHLRL LVLSLTTLIA ISLLSRLPAW SLLELRSFDY LSTVDDPRPP
     PGGPVIVAID EPSLADINAQ WPWPRGLHAE LISQLRAAGA RVIGLDIIMA EPSNPDNDAA
     ITRAVGPDVV LAGDETLIET PQASQLIRAT PLPQLTDAGA VTGIASIDLS GDGIFRRIPG
     YDDGFATMLA KASGVAPEAL PAGRLIQSFG PARSYPTVSY YQALDPKNLL PPDYFKDRVV
     LVGLSLQNAP EIDKGGVDAF ATPYTVHTGK LVSGVEIQAT IYDNIRRGLS IAEAGLPTVA
     ACILISVLLA AATVWRSTGW LTVVNSATAL LAFAAVSAAG IRLAHVFVSP LGPTVAYISV
     VFGQAAFDFA EERRNKRQIT RAFAQYISPD LVKRLSSDPT QLKLGGERRT LSVLFSDVRG
     FTTIAETLKD DPEQLTGLIN RLLTPLSDVV MDHGGTIDKY MGDCIMAFWN APLDDPDHAL
     HAVRASLAMQ AAISRLNGQL EREAAALGRK PHVLKMGVGI NTGECIVGNM GSTRRFDYSC
     LGDSVNLASR LEGASKNYGV ALLLGEETAR LVADAYIIVE LDRIIVKGRT VPSPIFTVVH
     KADAKALAAH QAFIDAKYAG TLAPSDVIFE KLAGDIPELA AYYAIVQDAL VGDGGE
//