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Q2K5P2

- FTHS_RHIEC

UniProt

Q2K5P2 - FTHS_RHIEC

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Rhizobium etli (strain CFN 42 / ATCC 51251)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi68 – 758ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRETL347834:GJJ0-3092-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:RHE_CH03078
    OrganismiRhizobium etli (strain CFN 42 / ATCC 51251)
    Taxonomic identifieri347834 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
    ProteomesiUP000001936: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 559559Formate--tetrahydrofolate ligasePRO_0000293052Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi347834.RHE_CH03078.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2K5P2.
    SMRiQ2K5P2. Positions 7-557.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiIANSVSM.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2K5P2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSIKSDIEI ARAATKRPIF EIGAKLGIAA EQLVPYGHDK AKVSAEFIAA    50
    QAGKKDGKLI LVTAINPTPA GEGKTTTTVG LGDGLNRIGK KAIVCIREAS 100
    LGPCFGVKGG AAGGGYAQVV PMEDINLHFT GDFHAITSAH NLLAAIIDNH 150
    IYWGNEENID IRRITWRRVM DMNDRALRSM ISSLGGVANG FPRQGGFDIT 200
    VASEVMAILC LATDLKDLER RLGDIIIGYR FDKTPVHARD LKADGAMAVL 250
    LKDAMQPNLV QTLESNPAFV HGGPFANIAH GCNSVTATKT ALKLGEYVVT 300
    EAGFGADLGA EKFFDIKCRK AGLRPDAAVI VATVRALKMN GGVKKEDLGT 350
    EDVAALKKGC ANLGRHVANV RRFGVPVVVA INHFVSDTDA EIAAVKEFVS 400
    RLGAEAILCQ HWAKGSAGIE ELAHKVVELA ESGQAKFQPL YGDDISLFEK 450
    IEIIASKIYH AGEVTADKAV RDQLQSWEEQ GYGKLPVCMA KTQYSFSTDP 500
    NLRGAPEGHI VSVREVRLSA GAGFVVAITG EIMTMPGLPK SPSAERIFLN 550
    DQGYIEGLF 559
    Length:559
    Mass (Da):59,740
    Last modified:March 7, 2006 - v1
    Checksum:i77EE4A7AB92E53A6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000133 Genomic DNA. Translation: ABC91844.1.
    RefSeqiWP_011426314.1. NC_007761.1.
    YP_470571.1. NC_007761.1.

    Genome annotation databases

    EnsemblBacteriaiABC91844; ABC91844; RHE_CH03078.
    GeneIDi3894039.
    KEGGiret:RHE_CH03078.
    PATRICi23087793. VBIRhiEtl108884_3547.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000133 Genomic DNA. Translation: ABC91844.1 .
    RefSeqi WP_011426314.1. NC_007761.1.
    YP_470571.1. NC_007761.1.

    3D structure databases

    ProteinModelPortali Q2K5P2.
    SMRi Q2K5P2. Positions 7-557.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 347834.RHE_CH03078.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC91844 ; ABC91844 ; RHE_CH03078 .
    GeneIDi 3894039.
    KEGGi ret:RHE_CH03078.
    PATRICi 23087793. VBIRhiEtl108884_3547.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi IANSVSM.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci RETL347834:GJJ0-3092-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CFN 42 / ATCC 51251.

    Entry informationi

    Entry nameiFTHS_RHIEC
    AccessioniPrimary (citable) accession number: Q2K5P2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3