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Q2K5P2

- FTHS_RHIEC

UniProt

Q2K5P2 - FTHS_RHIEC

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Rhizobium etli (strain CFN 42 / ATCC 51251)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 758ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRETL347834:GJJ0-3092-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:RHE_CH03078
OrganismiRhizobium etli (strain CFN 42 / ATCC 51251)
Taxonomic identifieri347834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
ProteomesiUP000001936: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Formate--tetrahydrofolate ligasePRO_0000293052Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi347834.RHE_CH03078.

Structurei

3D structure databases

ProteinModelPortaliQ2K5P2.
SMRiQ2K5P2. Positions 7-557.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIANSVSM.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2K5P2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSIKSDIEI ARAATKRPIF EIGAKLGIAA EQLVPYGHDK AKVSAEFIAA
60 70 80 90 100
QAGKKDGKLI LVTAINPTPA GEGKTTTTVG LGDGLNRIGK KAIVCIREAS
110 120 130 140 150
LGPCFGVKGG AAGGGYAQVV PMEDINLHFT GDFHAITSAH NLLAAIIDNH
160 170 180 190 200
IYWGNEENID IRRITWRRVM DMNDRALRSM ISSLGGVANG FPRQGGFDIT
210 220 230 240 250
VASEVMAILC LATDLKDLER RLGDIIIGYR FDKTPVHARD LKADGAMAVL
260 270 280 290 300
LKDAMQPNLV QTLESNPAFV HGGPFANIAH GCNSVTATKT ALKLGEYVVT
310 320 330 340 350
EAGFGADLGA EKFFDIKCRK AGLRPDAAVI VATVRALKMN GGVKKEDLGT
360 370 380 390 400
EDVAALKKGC ANLGRHVANV RRFGVPVVVA INHFVSDTDA EIAAVKEFVS
410 420 430 440 450
RLGAEAILCQ HWAKGSAGIE ELAHKVVELA ESGQAKFQPL YGDDISLFEK
460 470 480 490 500
IEIIASKIYH AGEVTADKAV RDQLQSWEEQ GYGKLPVCMA KTQYSFSTDP
510 520 530 540 550
NLRGAPEGHI VSVREVRLSA GAGFVVAITG EIMTMPGLPK SPSAERIFLN

DQGYIEGLF
Length:559
Mass (Da):59,740
Last modified:March 7, 2006 - v1
Checksum:i77EE4A7AB92E53A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000133 Genomic DNA. Translation: ABC91844.1.
RefSeqiYP_470571.1. NC_007761.1.

Genome annotation databases

EnsemblBacteriaiABC91844; ABC91844; RHE_CH03078.
GeneIDi3894039.
KEGGiret:RHE_CH03078.
PATRICi23087793. VBIRhiEtl108884_3547.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000133 Genomic DNA. Translation: ABC91844.1 .
RefSeqi YP_470571.1. NC_007761.1.

3D structure databases

ProteinModelPortali Q2K5P2.
SMRi Q2K5P2. Positions 7-557.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 347834.RHE_CH03078.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC91844 ; ABC91844 ; RHE_CH03078 .
GeneIDi 3894039.
KEGGi ret:RHE_CH03078.
PATRICi 23087793. VBIRhiEtl108884_3547.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IANSVSM.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci RETL347834:GJJ0-3092-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CFN 42 / ATCC 51251.

Entry informationi

Entry nameiFTHS_RHIEC
AccessioniPrimary (citable) accession number: Q2K5P2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 7, 2006
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3