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Q2K2T6

- PUR9_RHIEC

UniProt

Q2K2T6 - PUR9_RHIEC

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, RHE_CH04107
Organism
Rhizobium etli (strain CFN 42 / ATCC 51251)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciRETL347834:GJJ0-4125-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:RHE_CH04107
OrganismiRhizobium etli (strain CFN 42 / ATCC 51251)
Taxonomic identifieri347834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
ProteomesiUP000001936: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 538538Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000018947Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi347834.RHE_CH04107.

Structurei

3D structure databases

ProteinModelPortaliQ2K2T6.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiCGVATGP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2K2T6-1 [UniParc]FASTAAdd to Basket

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MAVISKKIPA PDKVEIKTAL LSVFDKTGIV ELAQALSERG VRLLSTGGTY    50
KAIAAAGLAV TDVSDITGFP EIMDGRVKTL HPTVHGGLLA IRDDNEHQEA 100
MKKHGIEGID LAVINLYPFE EVRAAGGDYP TTVENIDIGG PAMIRASAKN 150
HAYVTILTDP NDYAEFKEQL SADAGKTAYA FRQRMAAKAY ARTAAYDAAI 200
SNWFAEALSI DTPRHRVIGG VLKEEMRYGE NPHQRAAFYV TGEKRPGVST 250
AVLLQGKQLS YNNINDTDAA YELVAEFLPE RAPACAIIKH ANPCGVATGS 300
SLIEAYQRAL ACDSVSAFGG IIALNQILDA ETAEEIVKLF TEVIIAPDVT 350
EEAKAIVARK PNLRLLSAGG LPDPRVAGLT AKTVSGGLLV QSRDNGMVED 400
LELKVVTRRA PTGQELEDMK FAFKVGKHVK SNAVVYAKDG QTAGIGAGQM 450
SRVDSARIAA LKAEEAAKAL GLAVPMTKGS AVASEAFLPF ADGLLSMIAA 500
GATAVIQPGG SMRDQEVIDA ANEHGIAMVF TGMRHFRH 538
Length:538
Mass (Da):57,150
Last modified:March 7, 2006 - v1
Checksum:i2FA8DBB6E81B62DD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000133 Genomic DNA. Translation: ABC92850.1.
RefSeqiYP_471577.1. NC_007761.1.

Genome annotation databases

EnsemblBacteriaiABC92850; ABC92850; RHE_CH04107.
GeneIDi3892030.
KEGGiret:RHE_CH04107.
PATRICi23089968. VBIRhiEtl108884_4616.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000133 Genomic DNA. Translation: ABC92850.1 .
RefSeqi YP_471577.1. NC_007761.1.

3D structure databases

ProteinModelPortali Q2K2T6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 347834.RHE_CH04107.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC92850 ; ABC92850 ; RHE_CH04107 .
GeneIDi 3892030.
KEGGi ret:RHE_CH04107.
PATRICi 23089968. VBIRhiEtl108884_4616.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi CGVATGP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci RETL347834:GJJ0-4125-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CFN 42 / ATCC 51251.

Entry informationi

Entry nameiPUR9_RHIEC
AccessioniPrimary (citable) accession number: Q2K2T6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 7, 2006
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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