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Q2K2R7

- Q2K2R7_RHIEC

UniProt

Q2K2R7 - Q2K2R7_RHIEC

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Protein
Uroporphyrinogen decarboxylase
Gene
hemE, RHE_CH04126
Organism
Rhizobium etli (strain CFN 42 / ATCC 51251)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity.UniRule annotationSAAS annotations

Catalytic activityi

Uroporphyrinogen III = coproporphyrinogen + 4 CO2.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei52 – 521Substrate By similarityUniRule annotation
Sitei52 – 521Transition state stabilizer By similarityUniRule annotation
Binding sitei127 – 1271Substrate By similarityUniRule annotation
Binding sitei182 – 1821Substrate By similarityUniRule annotation
Binding sitei297 – 2971Substrate By similarityUniRule annotation

GO - Molecular functioni

  1. uroporphyrinogen decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotationSAAS annotations, Lyase

Keywords - Biological processi

Porphyrin biosynthesisUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciRETL347834:GJJ0-4144-MONOMER.
UniPathwayiUPA00251; UER00321.

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen decarboxylaseUniRule annotation (EC:4.1.1.37UniRule annotation)
Short name:
UPDUniRule annotation
Short name:
URO-DUniRule annotation
Gene namesi
Name:hemEUniRule annotationImported
Ordered Locus Names:RHE_CH04126Imported
OrganismiRhizobium etli (strain CFN 42 / ATCC 51251)Imported
Taxonomic identifieri347834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
ProteomesiUP000001936: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi347834.RHE_CH04126.

Structurei

3D structure databases

ProteinModelPortaliQ2K2R7.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 65Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0407.
KOiK01599.
OMAiDCVALDN.
OrthoDBiEOG6VXF6H.

Family and domain databases

HAMAPiMF_00218. URO_D.
InterProiIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PfamiPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01464. hemE. 1 hit.
PROSITEiPS00907. UROD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2K2R7-1 [UniParc]FASTAAdd to Basket

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MRQAGRYLPE YRETRAKAGS FLDLCYTPDH AVEVTLQPIR RYGFDAAILF    50
SDILVIPDAM KRNVRFTEGH GPEMDPIDEA GIGRLNGDEV VDYLRPVLET 100
VRRLRHELPE ETALLGFCGA PWTVATYMIA GHGTPDQAPA RLFAYEHPRA 150
FEHLLMLLAD VSADYLVAQI DAGADAVQIF DSWAGVLGEK EFDAFAVKPV 200
ARMIASIKAR RPQARVIAFA KGAGYQLKTY RQKTGADAIG LDWSVPLAFA 250
AELQKDGPVQ GNLDPMRVVA GGRALEEGID DILHHLGNGP LIFNLGHGIT 300
PQADPEHVRM LVERVRGSRM PRA 323
Length:323
Mass (Da):35,603
Last modified:March 7, 2006 - v1
Checksum:i11D122A8039C4F3A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000133 Genomic DNA. Translation: ABC92869.1.
RefSeqiYP_471596.1. NC_007761.1.

Genome annotation databases

EnsemblBacteriaiABC92869; ABC92869; RHE_CH04126.
GeneIDi3892018.
KEGGiret:RHE_CH04126.
PATRICi23090006. VBIRhiEtl108884_4635.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000133 Genomic DNA. Translation: ABC92869.1 .
RefSeqi YP_471596.1. NC_007761.1.

3D structure databases

ProteinModelPortali Q2K2R7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 347834.RHE_CH04126.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC92869 ; ABC92869 ; RHE_CH04126 .
GeneIDi 3892018.
KEGGi ret:RHE_CH04126.
PATRICi 23090006. VBIRhiEtl108884_4635.

Phylogenomic databases

eggNOGi COG0407.
KOi K01599.
OMAi DCVALDN.
OrthoDBi EOG6VXF6H.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00321 .
BioCyci RETL347834:GJJ0-4144-MONOMER.

Family and domain databases

HAMAPi MF_00218. URO_D.
InterProi IPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view ]
Pfami PF01208. URO-D. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01464. hemE. 1 hit.
PROSITEi PS00907. UROD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CFN 42 / ATCC 51251.

Entry informationi

Entry nameiQ2K2R7_RHIEC
AccessioniPrimary (citable) accession number: Q2K2R7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: June 11, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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