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Protein

Uroporphyrinogen decarboxylase

Gene

hemE

Organism
Rhizobium etli (strain CFN 42 / ATCC 51251)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.UniRule annotationSAAS annotation

Catalytic activityi

Uroporphyrinogen III = coproporphyrinogen + 4 CO2.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei52 – 521SubstrateUniRule annotation
Sitei52 – 521Transition state stabilizerUniRule annotation
Binding sitei127 – 1271SubstrateUniRule annotation
Binding sitei182 – 1821SubstrateUniRule annotation
Binding sitei297 – 2971SubstrateUniRule annotation

GO - Molecular functioni

  1. uroporphyrinogen decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotationSAAS annotation, Lyase

Keywords - Biological processi

Porphyrin biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciRETL347834:GJJ0-4144-MONOMER.
UniPathwayiUPA00251; UER00321.

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen decarboxylaseUniRule annotationSAAS annotation (EC:4.1.1.37UniRule annotationSAAS annotation)
Short name:
UPDUniRule annotation
Short name:
URO-DUniRule annotation
Gene namesi
Name:hemEUniRule annotationImported
Ordered Locus Names:RHE_CH04126Imported
OrganismiRhizobium etli (strain CFN 42 / ATCC 51251)Imported
Taxonomic identifieri347834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
ProteomesiUP000001936 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi347834.RHE_CH04126.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 65Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the uroporphyrinogen decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0407.
KOiK01599.
OMAiFIDACFR.
OrthoDBiEOG6VXF6H.

Family and domain databases

HAMAPiMF_00218. URO_D.
InterProiIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PfamiPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01464. hemE. 1 hit.
PROSITEiPS00907. UROD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2K2R7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQAGRYLPE YRETRAKAGS FLDLCYTPDH AVEVTLQPIR RYGFDAAILF
60 70 80 90 100
SDILVIPDAM KRNVRFTEGH GPEMDPIDEA GIGRLNGDEV VDYLRPVLET
110 120 130 140 150
VRRLRHELPE ETALLGFCGA PWTVATYMIA GHGTPDQAPA RLFAYEHPRA
160 170 180 190 200
FEHLLMLLAD VSADYLVAQI DAGADAVQIF DSWAGVLGEK EFDAFAVKPV
210 220 230 240 250
ARMIASIKAR RPQARVIAFA KGAGYQLKTY RQKTGADAIG LDWSVPLAFA
260 270 280 290 300
AELQKDGPVQ GNLDPMRVVA GGRALEEGID DILHHLGNGP LIFNLGHGIT
310 320
PQADPEHVRM LVERVRGSRM PRA
Length:323
Mass (Da):35,603
Last modified:March 7, 2006 - v1
Checksum:i11D122A8039C4F3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000133 Genomic DNA. Translation: ABC92869.1.
RefSeqiWP_011427305.1. NC_007761.1.
YP_471596.1. NC_007761.1.

Genome annotation databases

EnsemblBacteriaiABC92869; ABC92869; RHE_CH04126.
KEGGiret:RHE_CH04126.
PATRICi23090006. VBIRhiEtl108884_4635.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000133 Genomic DNA. Translation: ABC92869.1.
RefSeqiWP_011427305.1. NC_007761.1.
YP_471596.1. NC_007761.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi347834.RHE_CH04126.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABC92869; ABC92869; RHE_CH04126.
KEGGiret:RHE_CH04126.
PATRICi23090006. VBIRhiEtl108884_4635.

Phylogenomic databases

eggNOGiCOG0407.
KOiK01599.
OMAiFIDACFR.
OrthoDBiEOG6VXF6H.

Enzyme and pathway databases

UniPathwayiUPA00251; UER00321.
BioCyciRETL347834:GJJ0-4144-MONOMER.

Family and domain databases

HAMAPiMF_00218. URO_D.
InterProiIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PfamiPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01464. hemE. 1 hit.
PROSITEiPS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CFN 42 / ATCC 51251Imported.

Entry informationi

Entry nameiQ2K2R7_RHIEC
AccessioniPrimary (citable) accession number: Q2K2R7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: April 29, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.