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Q2K2R7

- Q2K2R7_RHIEC

UniProt

Q2K2R7 - Q2K2R7_RHIEC

Protein

Uroporphyrinogen decarboxylase

Gene

hemE

Organism
Rhizobium etli (strain CFN 42 / ATCC 51251)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.UniRule annotationSAAS annotation

    Catalytic activityi

    Uroporphyrinogen III = coproporphyrinogen + 4 CO2.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei52 – 521SubstrateUniRule annotation
    Sitei52 – 521Transition state stabilizerUniRule annotation
    Binding sitei127 – 1271SubstrateUniRule annotation
    Binding sitei182 – 1821SubstrateUniRule annotation
    Binding sitei297 – 2971SubstrateUniRule annotation

    GO - Molecular functioni

    1. uroporphyrinogen decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    DecarboxylaseUniRule annotationSAAS annotation, Lyase

    Keywords - Biological processi

    Porphyrin biosynthesisUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciRETL347834:GJJ0-4144-MONOMER.
    UniPathwayiUPA00251; UER00321.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uroporphyrinogen decarboxylaseUniRule annotation (EC:4.1.1.37UniRule annotation)
    Short name:
    UPDUniRule annotation
    Short name:
    URO-DUniRule annotation
    Gene namesi
    Name:hemEUniRule annotationImported
    Ordered Locus Names:RHE_CH04126Imported
    OrganismiRhizobium etli (strain CFN 42 / ATCC 51251)Imported
    Taxonomic identifieri347834 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
    ProteomesiUP000001936: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi347834.RHE_CH04126.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2K2R7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 65Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the uroporphyrinogen decarboxylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0407.
    KOiK01599.
    OMAiDCVALDN.
    OrthoDBiEOG6VXF6H.

    Family and domain databases

    HAMAPiMF_00218. URO_D.
    InterProiIPR006361. Uroporphyrinogen_deCO2ase_HemE.
    IPR000257. Uroporphyrinogen_deCOase.
    [Graphical view]
    PfamiPF01208. URO-D. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01464. hemE. 1 hit.
    PROSITEiPS00907. UROD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2K2R7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRQAGRYLPE YRETRAKAGS FLDLCYTPDH AVEVTLQPIR RYGFDAAILF    50
    SDILVIPDAM KRNVRFTEGH GPEMDPIDEA GIGRLNGDEV VDYLRPVLET 100
    VRRLRHELPE ETALLGFCGA PWTVATYMIA GHGTPDQAPA RLFAYEHPRA 150
    FEHLLMLLAD VSADYLVAQI DAGADAVQIF DSWAGVLGEK EFDAFAVKPV 200
    ARMIASIKAR RPQARVIAFA KGAGYQLKTY RQKTGADAIG LDWSVPLAFA 250
    AELQKDGPVQ GNLDPMRVVA GGRALEEGID DILHHLGNGP LIFNLGHGIT 300
    PQADPEHVRM LVERVRGSRM PRA 323
    Length:323
    Mass (Da):35,603
    Last modified:March 7, 2006 - v1
    Checksum:i11D122A8039C4F3A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000133 Genomic DNA. Translation: ABC92869.1.
    RefSeqiYP_471596.1. NC_007761.1.

    Genome annotation databases

    EnsemblBacteriaiABC92869; ABC92869; RHE_CH04126.
    GeneIDi3892018.
    KEGGiret:RHE_CH04126.
    PATRICi23090006. VBIRhiEtl108884_4635.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000133 Genomic DNA. Translation: ABC92869.1 .
    RefSeqi YP_471596.1. NC_007761.1.

    3D structure databases

    ProteinModelPortali Q2K2R7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 347834.RHE_CH04126.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC92869 ; ABC92869 ; RHE_CH04126 .
    GeneIDi 3892018.
    KEGGi ret:RHE_CH04126.
    PATRICi 23090006. VBIRhiEtl108884_4635.

    Phylogenomic databases

    eggNOGi COG0407.
    KOi K01599.
    OMAi DCVALDN.
    OrthoDBi EOG6VXF6H.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00321 .
    BioCyci RETL347834:GJJ0-4144-MONOMER.

    Family and domain databases

    HAMAPi MF_00218. URO_D.
    InterProi IPR006361. Uroporphyrinogen_deCO2ase_HemE.
    IPR000257. Uroporphyrinogen_deCOase.
    [Graphical view ]
    Pfami PF01208. URO-D. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01464. hemE. 1 hit.
    PROSITEi PS00907. UROD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CFN 42 / ATCC 51251Imported.

    Entry informationi

    Entry nameiQ2K2R7_RHIEC
    AccessioniPrimary (citable) accession number: Q2K2R7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 7, 2006
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3