Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q2K2R7 (Q2K2R7_RHIEC) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase HAMAP-Rule MF_00218
Short name=UPD HAMAP-Rule MF_00218
Short name=URO-D HAMAP-Rule MF_00218
EC=4.1.1.37 HAMAP-Rule MF_00218
Gene names
Name:hemE HAMAP-Rule MF_00218 EMBL ABC92869.1
Ordered Locus Names:RHE_CH04126 EMBL ABC92869.1
OrganismRhizobium etli (strain CFN 42 / ATCC 51251) [Complete proteome] [HAMAP] EMBL ABC92869.1
Taxonomic identifier347834 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Rhizobium ›

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP-Rule MF_00218 SAAS SAAS006361

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP-Rule MF_00218 SAAS SAAS006361

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP-Rule MF_00218 SAAS SAAS006361

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00218 SAAS SAAS006361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00218 SAAS SAAS006361.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family. HAMAP-Rule MF_00218 RuleBase RU004169

Ontologies

Keywords
   Biological processPorphyrin biosynthesis HAMAP-Rule MF_00218 SAAS SAAS006361
   Cellular componentCytoplasm HAMAP-Rule MF_00218 SAAS SAAS006361
   Molecular functionDecarboxylase HAMAP-Rule MF_00218 SAAS SAAS006361
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processprotoporphyrinogen IX biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region2 – 65Substrate binding By similarity HAMAP-Rule MF_00218

Sites

Binding site521Substrate By similarity HAMAP-Rule MF_00218
Binding site1271Substrate By similarity HAMAP-Rule MF_00218
Binding site1821Substrate By similarity HAMAP-Rule MF_00218
Binding site2971Substrate By similarity HAMAP-Rule MF_00218
Site521Transition state stabilizer By similarity HAMAP-Rule MF_00218

Sequences

Sequence LengthMass (Da)Tools
Q2K2R7 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: 11D122A8039C4F3A

FASTA32335,603
        10         20         30         40         50         60 
MRQAGRYLPE YRETRAKAGS FLDLCYTPDH AVEVTLQPIR RYGFDAAILF SDILVIPDAM 

        70         80         90        100        110        120 
KRNVRFTEGH GPEMDPIDEA GIGRLNGDEV VDYLRPVLET VRRLRHELPE ETALLGFCGA 

       130        140        150        160        170        180 
PWTVATYMIA GHGTPDQAPA RLFAYEHPRA FEHLLMLLAD VSADYLVAQI DAGADAVQIF 

       190        200        210        220        230        240 
DSWAGVLGEK EFDAFAVKPV ARMIASIKAR RPQARVIAFA KGAGYQLKTY RQKTGADAIG 

       250        260        270        280        290        300 
LDWSVPLAFA AELQKDGPVQ GNLDPMRVVA GGRALEEGID DILHHLGNGP LIFNLGHGIT 

       310        320 
PQADPEHVRM LVERVRGSRM PRA

« Hide

References

[1]"The partitioned Rhizobium etli genome: genetic and metabolic redundancy in seven interacting replicons."
Gonzalez V., Santamaria R.I., Bustos P., Hernandez-Gonzalez I., Medrano-Soto A., Moreno-Hagelsieb G., Janga S.C., Ramirez M.A., Jimenez-Jacinto V., Collado-Vides J., Davila G.
Proc. Natl. Acad. Sci. U.S.A. 103:3834-3839(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CFN 42 / ATCC 51251.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000133 Genomic DNA. Translation: ABC92869.1.
RefSeqYP_471596.1. NC_007761.1.

3D structure databases

ProteinModelPortalQ2K2R7.
ModBaseSearch...

Protein-protein interaction databases

STRING347834.RHE_CH04126.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABC92869; ABC92869; RHE_CH04126.
GeneID3892018.
KEGGret:RHE_CH04126.
PATRIC23090006. VBIRhiEtl108884_4635.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0407.
KOK01599.
OMATLATYMI.
ProtClustDBPRK00115.

Enzyme and pathway databases

BioCycRETL347834:GJJ0-4144-MONOMER.
UniPathwayUPA00251; UER00321.

Family and domain databases

HAMAPMF_00218. URO_D.
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PANTHERPTHR21091:SF2. PTHR21091:SF2. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. hemE. 1 hit.
PROSITEPS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ2K2R7_RHIEC
AccessionPrimary (citable) accession number: Q2K2R7
Entry history
Integrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info