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Q2K0X8

- THIM_RHIEC

UniProt

Q2K0X8 - THIM_RHIEC

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Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Rhizobium etli (strain CFN 42 / ATCC 51251)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371Substrate; via amide nitrogenUniRule annotation
Binding sitei112 – 1121ATPUniRule annotation
Binding sitei158 – 1581ATPUniRule annotation
Binding sitei185 – 1851Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRETL347834:GJJ0-5054-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
Short name:
TH kinaseUniRule annotation
Short name:
Thz kinaseUniRule annotation
Gene namesi
Name:thiMUniRule annotation
Ordered Locus Names:RHE_PE00337
Encoded oniPlasmid p42e0 Publication
OrganismiRhizobium etli (strain CFN 42 / ATCC 51251)
Taxonomic identifieri347834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
ProteomesiUP000001936: Plasmid p42e

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Hydroxyethylthiazole kinasePRO_0000383889Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi347834.RHE_PE00337.

Structurei

3D structure databases

ProteinModelPortaliQ2K0X8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OMAiMANEAPE.
OrthoDBiEOG628F8M.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00694. thiM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2K0X8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLDAMREKPP LVHCITNYVA MNIAANVLLA SGASPAMVHA PEEAGEFAGI
60 70 80 90 100
ASALTVNIGT LSTQWIDGMQ AAAKAAASAG KPWVLDPVAH YATTFRRQAV
110 120 130 140 150
ADLLALKPTI IRGNASEIIA LAGGESRGQG VDSRDPVEQA EDSARRLAER
160 170 180 190 200
QQAIVAVTGA VDFVTDGERA VRIKGGSVLM PEVTALGCSL TCLIGAFAAT
210 220 230 240 250
APEDLFGATV AALATFAVAG EDAALGAAGP GSFAWRFLDA LAALDGEALD

ARARVSLA
Length:258
Mass (Da):26,338
Last modified:March 7, 2006 - v1
Checksum:i1E56309883AB05F9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000137 Genomic DNA. Translation: ABC93772.1.
RefSeqiWP_011428191.1. NC_007765.1.
YP_472499.1. NC_007765.1.

Genome annotation databases

EnsemblBacteriaiABC93772; ABC93772; RHE_PE00337.
GeneIDi3895735.
KEGGiret:RHE_PE00337.
PATRICi23091948. VBIRhiEtl108884_5603.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000137 Genomic DNA. Translation: ABC93772.1 .
RefSeqi WP_011428191.1. NC_007765.1.
YP_472499.1. NC_007765.1.

3D structure databases

ProteinModelPortali Q2K0X8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 347834.RHE_PE00337.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC93772 ; ABC93772 ; RHE_PE00337 .
GeneIDi 3895735.
KEGGi ret:RHE_PE00337.
PATRICi 23091948. VBIRhiEtl108884_5603.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.
OMAi MANEAPE.
OrthoDBi EOG628F8M.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci RETL347834:GJJ0-5054-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00694. thiM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CFN 42 / ATCC 51251.

Entry informationi

Entry nameiTHIM_RHIEC
AccessioniPrimary (citable) accession number: Q2K0X8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 7, 2006
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3