ID   Q2K042_RHIEC            Unreviewed;       570 AA.
AC   Q2K042;
DT   07-MAR-2006, integrated into UniProtKB/TrEMBL.
DT   07-MAR-2006, sequence version 1.
DT   27-MAR-2024, entry version 118.
DE   SubName: Full=Adenylate cyclase protein {ECO:0000313|EMBL:ABC93488.1};
DE            EC=4.6.1.1 {ECO:0000313|EMBL:ABC93488.1};
GN   Name=cyaCe {ECO:0000313|EMBL:ABC93488.1};
GN   OrderedLocusNames=RHE_PE00049 {ECO:0000313|EMBL:ABC93488.1};
OS   Rhizobium etli (strain CFN 42 / ATCC 51251).
OG   Plasmid p42e {ECO:0000313|EMBL:ABC93488.1,
OG   ECO:0000313|Proteomes:UP000001936}.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=347834 {ECO:0000313|EMBL:ABC93488.1, ECO:0000313|Proteomes:UP000001936};
RN   [1] {ECO:0000313|EMBL:ABC93488.1, ECO:0000313|Proteomes:UP000001936}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFN 42 / ATCC 51251 {ECO:0000313|Proteomes:UP000001936};
RX   PubMed=16505379; DOI=10.1073/pnas.0508502103;
RA   Gonzalez V., Santamaria R.I., Bustos P., Hernandez-Gonzalez I.,
RA   Medrano-Soto A., Moreno-Hagelsieb G., Janga S.C., Ramirez M.A.,
RA   Jimenez-Jacinto V., Collado-Vides J., Davila G.;
RT   "The partitioned Rhizobium etli genome: genetic and metabolic redundancy in
RT   seven interacting replicons.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:3834-3839(2006).
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DR   EMBL; CP000137; ABC93488.1; -; Genomic_DNA.
DR   RefSeq; WP_011427907.1; NC_007765.1.
DR   AlphaFoldDB; Q2K042; -.
DR   KEGG; ret:RHE_PE00049; -.
DR   HOGENOM; CLU_492377_0_0_5; -.
DR   OrthoDB; 341967at2; -.
DR   Proteomes; UP000001936; Plasmid p42e.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   CDD; cd00207; fer2; 1.
DR   Gene3D; 3.10.20.30; -; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR036010; 2Fe-2S_ferredoxin-like_sf.
DR   InterPro; IPR001041; 2Fe-2S_ferredoxin-type.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR034804; SQR/QFR_C/D.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   PANTHER; PTHR43081:SF17; BLL5647 PROTEIN; 1.
DR   Pfam; PF00111; Fer2; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF54292; 2Fe-2S ferredoxin-like; 1.
DR   SUPFAM; SSF81343; Fumarate reductase respiratory complex transmembrane subunits; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS51085; 2FE2S_FER_2; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Lyase {ECO:0000313|EMBL:ABC93488.1}; Membrane {ECO:0000256|SAM:Phobius};
KW   Plasmid {ECO:0000313|EMBL:ABC93488.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001936};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        66..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        95..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        146..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        231..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          262..357
FT                   /note="2Fe-2S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51085"
FT   DOMAIN          379..511
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   570 AA;  61966 MW;  0541D825AD14533F CRC64;
     MTTASVTGIF SERSIRRARL GSGLVIFIFV LLHLSNHALG LISLAAADKA RYLFLAIWRN
     PLGTTVFYAS VLIHMGLVLR AIYMRRSLVM PKGETAQLVL GLLIPLLLID HVIGTRIAHE
     LYGYIDDYET VVEQLWIKNP ANGARQVLGV LAVWFHGCIG IHFWLRYRPW YAGSAPLLLA
     LAILVPVLSV LGFVQMGRTL ADPSYQLATN PYEVNLNAHY LHDPEVRARI AAVRAGLYGA
     FSASLLLVVV ARARRRLKER LDQVAVHYPG GEVIRVPRGF TVLEASRLGG LPHYSVCGGK
     GQCSTCRVQI LGDYESLPAP DKMEQTTLKR INAGPDVRLA CQLRPDRDVA VAPLLVPAVE
     TALPANSQET SPGREREIAV LFVDIRHFTT LTETRLPFDV VFLLNRYFAI IGKAVEQAGG
     RLDKFIGDGA MALFGLNTAP EEACRQALKA AAAIVTEIEK LADELADELV LPLRIAIGIH
     TGPAVIGTMG YGRVRSVTAI GDTVNVASRL ESAAKEFEAA IVISEPVAAR SGADLAGIES
     HEISVRGRAL PLKVYVIPRE KAGEPLEGKA
//