Reviewed,
UniProtKB/Swiss-Prot Q2JZV0 (FOLD2_RHIEC)
Last modified
November 25, 2008.
Version 20.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Bifunctional protein folD 2 Including the following 2 domains: 1- Recommended name: Methylenetetrahydrofolate dehydrogenase EC=1.5.1.5 2- Recommended name: Methenyltetrahydrofolate cyclohydrolase EC=3.5.4.9 | ||||
| Gene names |
| ||||
| Encoded on | Plasmid p42e | ||||
| Organism | Rhizobium etli (strain CFN 42 / ATCC 51251) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 347834 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Rhizobium |
Protein attributes
| Sequence length | 299 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate By similarity. |
| Catalytic activity | 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH. 5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate. |
| Pathway | |
| Subunit structure | Homodimer By similarity. |
| Sequence similarities | Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 299 | 299 | Bifunctional protein folD 2 | PRO_0000268460 | |||
Sequences
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References
| [1] | "The partitioned Rhizobium etli genome: genetic and metabolic redundancy in seven interacting replicons." Gonzalez V., Santamaria R.I., Bustos P., Hernandez-Gonzalez I., Medrano-Soto A., Moreno-Hagelsieb G., Janga S.C., Ramirez M.A., Jimenez-Jacinto V., Collado-Vides J., Davila G. Proc. Natl. Acad. Sci. U.S.A. 103:3834-3839(2006) [PubMed: 16505379] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| CP000137 Genomic DNA. Translation: ABC93851.1. | |
| RefSeq | YP_472578.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3895624. |
| GenomeReviews | Gene locus RHE_PE00416 in contig CP000137_GR. |
| KEGG | ret:RHE_PE00416. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q2JZV0. |
Family and domain databases | |
| HAMAP | MF_01576. [Tree] |
| InterPro | IPR016040. NAD(P)-bd. IPR000672. THF_DHase/CycOHase. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| Pfam | PF00763. THF_DHG_CYH. 1 hit. PF02882. THF_DHG_CYH_C. 1 hit. [Graphical view] |
| PRINTS | PR00085. THFDHDRGNASE. |
| ProDom | PD002300. THFDhg/Cyc_hydro. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS00766. THF_DHG_CYH_1. False negative. PS00767. THF_DHG_CYH_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | FOLD2_RHIEC | ||||||||
| Accession | Primary (citable) accession number: Q2JZV0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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