Q2JZQ2 (TPIS2_RHIEC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Triosephosphate isomerase 2
Short name=TIM 2
EC=5.3.1.1

Alternative name(s):
Triose-phosphate isomerase 2

Gene names

Name:	tpiA2
Synonyms:	tpiAf
Ordered Locus Names:	RHE_PF00040

Encoded on

Plasmid p42f

Organism

Rhizobium etli (strain CFN 42 / ATCC 51251) [Complete proteome] [HAMAP]

Taxonomic identifier

347834 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Rhizobium

Protein attributes

Sequence length	267 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glyceraldehyde 3-phosphate = glycerone phosphate. HAMAP MF_00147_B
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00147_B Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. HAMAP MF_00147_B
Subunit structure	Homodimer By similarity. HAMAP MF_00147_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00147_B.
Sequence similarities	Belongs to the triosephosphate isomerase family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis Pentose shunt
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome Plasmid
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	triose-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 267	267	Triosephosphate isomerase 2 HAMAP MF_00147_B		PRO_0000236166
Sites
	Active site	95	1	Electrophile By similarity
	Active site	168	1	Proton acceptor By similarity
	Binding site	10	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2JZQ2 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 3A6085823E800D93	FASTA	267	29,175
	10 20 30 40 50 60 MVVWVGTSFK MNKTLEEALA FARRLADADL ERDPRVQRFV IPSFTAVREV KRVLTESSVK 70 80 90 100 110 120 VGAQNMHWED AGAWTGEISP LMLKDCRLDL VELGHSERRE HFGETDETVG LKAAAAIRHG 130 140 150 160 170 180 LTPLICIGET LQERNEGRAD AVLRRQVEAA LRGVDTEAGE APILLAYEPV WAIGVNGIPA 190 200 210 220 230 240 TADYASERHR GIAEVAKSIL GRPVPVLYGG SVNPGNCEEL IGQPDIDGLF IGRSAWSVEG 250 260 YLDILARVSA AIDRSSPRQT ASERKLP

References

[1]

"The partitioned Rhizobium etli genome: genetic and metabolic redundancy in seven interacting replicons." Gonzalez V., Santamaria R.I., Bustos P., Hernandez-Gonzalez I., Medrano-Soto A., Moreno-Hagelsieb G., Janga S.C., Ramirez M.A., Jimenez-Jacinto V., Collado-Vides J., Davila G. Proc. Natl. Acad. Sci. U.S.A. 103:3834-3839(2006) [PubMed: 16505379] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CFN 42 / ATCC 51251.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000138 Genomic DNA. Translation: ABC93934.1.
RefSeq	YP_472661.1. NC_007766.1.
3D structure databases
ProteinModelPortal	Q2JZQ2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2JZQ2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3896224.
GenomeReviews	Gene locus RHE_PF00040 in contig CP000138_GR.
KEGG	ret:RHE_PF00040.
PATRIC	23092293. VBIRhiEtl108884_5775.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0149.
HOGENOM	HBG708281.
OMA	WAIGVNG.
PhylomeDB	Q2JZQ2.
ProtClustDB	PRK00042.
Family and domain databases
HAMAP	MF_00147_B. TIM_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR022896. TrioseP_Isoase_bac/euk. IPR000652. Triosephosphate_isomerase. IPR020861. Triosephosphate_isomerase_AS. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01803.
PANTHER	PTHR21139. Triophos_ismrse. 1 hit.
Pfam	PF00121. TIM. 1 hit. [Graphical view]
SUPFAM	SSF51351. Triophos_ismrse. 1 hit.
TIGRFAMs	TIGR00419. Tim. 1 hit.
PROSITE	PS00171. TIM_1. 1 hit. PS51440. TIM_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TPIS2_RHIEC

Accession

Primary (citable) accession number: Q2JZQ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program