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Q2JZQ2 (TPIS2_RHIEC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Triosephosphate isomerase 2

Short name=TIM 2
EC=5.3.1.1
Alternative name(s):
Triose-phosphate isomerase 2
Gene names
Name:tpiA2
Synonyms:tpiAf
Ordered Locus Names:RHE_PF00040
Encoded onPlasmid p42f
OrganismRhizobium etli (strain CFN 42 / ATCC 51251) [Complete proteome] [HAMAP]
Taxonomic identifier347834 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glyceraldehyde 3-phosphate = glycerone phosphate. HAMAP-Rule MF_00147

Pathway

Carbohydrate biosynthesis; gluconeogenesis. HAMAP-Rule MF_00147

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. HAMAP-Rule MF_00147

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the triosephosphate isomerase family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
Pentose shunt
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Plasmid
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: HAMAP

glycolysis

Inferred from electronic annotation. Source: HAMAP

pentose-phosphate shunt

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiontriose-phosphate isomerase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267Triosephosphate isomerase 2 HAMAP-Rule MF_00147
PRO_0000236166

Sites

Active site951Electrophile By similarity
Active site1681Proton acceptor By similarity
Binding site101Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2JZQ2 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: 3A6085823E800D93

FASTA26729,175
        10         20         30         40         50         60 
MVVWVGTSFK MNKTLEEALA FARRLADADL ERDPRVQRFV IPSFTAVREV KRVLTESSVK 

        70         80         90        100        110        120 
VGAQNMHWED AGAWTGEISP LMLKDCRLDL VELGHSERRE HFGETDETVG LKAAAAIRHG 

       130        140        150        160        170        180 
LTPLICIGET LQERNEGRAD AVLRRQVEAA LRGVDTEAGE APILLAYEPV WAIGVNGIPA 

       190        200        210        220        230        240 
TADYASERHR GIAEVAKSIL GRPVPVLYGG SVNPGNCEEL IGQPDIDGLF IGRSAWSVEG 

       250        260 
YLDILARVSA AIDRSSPRQT ASERKLP 

« Hide

References

[1]"The partitioned Rhizobium etli genome: genetic and metabolic redundancy in seven interacting replicons."
Gonzalez V., Santamaria R.I., Bustos P., Hernandez-Gonzalez I., Medrano-Soto A., Moreno-Hagelsieb G., Janga S.C., Ramirez M.A., Jimenez-Jacinto V., Collado-Vides J., Davila G.
Proc. Natl. Acad. Sci. U.S.A. 103:3834-3839(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CFN 42 / ATCC 51251.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000138 Genomic DNA. Translation: ABC93934.1.
RefSeqYP_472661.1. NC_007766.1.

3D structure databases

ProteinModelPortalQ2JZQ2.
ModBaseSearch...

Protein-protein interaction databases

STRING347834.RHE_PF00040.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABC93934; ABC93934; RHE_PF00040.
GeneID3896224.
KEGGret:RHE_PF00040.
PATRIC23092293. VBIRhiEtl108884_5775.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0149.
KOK01803.
OMAWAIGVNG.
ProtClustDBPRK00042.

Enzyme and pathway databases

BioCycRETL347834:GJJ0-4184-MONOMER.
UniPathwayUPA00109; UER00189.
UPA00138.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00147_B. TIM_B.
InterProIPR013785. Aldolase_TIM.
IPR022896. TrioseP_Isoase_bac/euk.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
[Graphical view]
PANTHERPTHR21139. PTHR21139. 1 hit.
PfamPF00121. TIM. 1 hit.
[Graphical view]
SUPFAMSSF51351. Triophos_ismrse. 1 hit.
TIGRFAMsTIGR00419. tim. 1 hit.
PROSITEPS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTPIS2_RHIEC
AccessionPrimary (citable) accession number: Q2JZQ2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: March 7, 2006
Last modified: May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families