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Q2JXZ9

- UPPP_SYNJA

UniProt

Q2JXZ9 - UPPP_SYNJA

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Synechococcus sp. (strain JA-3-3Ab) (Cyanobacteria bacterium Yellowstone A-Prime)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciSSP321327:GHFX-88-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:CYA_0087
    OrganismiSynechococcus sp. (strain JA-3-3Ab) (Cyanobacteria bacterium Yellowstone A-Prime)
    Taxonomic identifieri321327 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000008818: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 276276Undecaprenyl-diphosphatasePRO_0000250275Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi321327.CYA_0087.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei46 – 6621HelicalUniRule annotationAdd
    BLAST
    Transmembranei94 – 11421HelicalUniRule annotationAdd
    BLAST
    Transmembranei122 – 14221HelicalUniRule annotationAdd
    BLAST
    Transmembranei152 – 17221HelicalUniRule annotationAdd
    BLAST
    Transmembranei196 – 21621HelicalUniRule annotationAdd
    BLAST
    Transmembranei226 – 24621HelicalUniRule annotationAdd
    BLAST
    Transmembranei253 – 27321HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiPIVIAGW.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2JXZ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLADIWYPNW WQALVLGMVQ GITEFLPISS TAHLRVFPAL LGWPDAGASF    50
    AAVIQLGSLG AVLIYFASDL RQLLLGSWKA WQKRDFQEES WRLLMGILVG 100
    TLPIVIAGWA VKAIWGSPPR QLWVVAAAAI GLALALGWAE RVGKRRRDLH 150
    SLGIGDGLWV GLAQALALIP GVSRSGVTLT AALLLDLQRS AAARYSFLLG 200
    IPALFLAGVA EFIAEFRAEA LLSQGLGTLS AFVFSYGSID WLIRFLQRSS 250
    TWVFIVYRIG FGLFIFLGLA LGFLQP 276
    Length:276
    Mass (Da):30,083
    Last modified:March 7, 2006 - v1
    Checksum:i39E5D9E10B5E0183
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000239 Genomic DNA. Translation: ABC98318.1.
    RefSeqiWP_011429010.1. NC_007775.1.
    YP_473581.1. NC_007775.1.

    Genome annotation databases

    EnsemblBacteriaiABC98318; ABC98318; CYA_0087.
    GeneIDi3897116.
    KEGGicya:CYA_0087.
    PATRICi23808441. VBISynSp90045_0089.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000239 Genomic DNA. Translation: ABC98318.1 .
    RefSeqi WP_011429010.1. NC_007775.1.
    YP_473581.1. NC_007775.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 321327.CYA_0087.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABC98318 ; ABC98318 ; CYA_0087 .
    GeneIDi 3897116.
    KEGGi cya:CYA_0087.
    PATRICi 23808441. VBISynSp90045_0089.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi PIVIAGW.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci SSP321327:GHFX-88-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses."
      Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.
      ISME J. 1:703-713(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JA-3-3Ab.

    Entry informationi

    Entry nameiUPPP_SYNJA
    AccessioniPrimary (citable) accession number: Q2JXZ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3