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Protein

Adaptive-response sensory-kinase SasA

Gene

sasA

Organism
Synechococcus sp. (strain JA-3-3Ab) (Cyanobacteria bacterium Yellowstone A-Prime)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

May be involved in signal transduction. Participates in the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with KaiC. Required for robustness of the circadian rhythm of gene expression and is involved in clock outputs.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Biological rhythms, Two-component regulatory system

Names & Taxonomyi

Protein namesi
Recommended name:
Adaptive-response sensory-kinase SasAUniRule annotation (EC:2.7.-.-UniRule annotation)
Alternative name(s):
Synechococcus adaptive sensor protein AUniRule annotation
Gene namesi
Name:sasAUniRule annotation
Ordered Locus Names:CYA_0637
OrganismiSynechococcus sp. (strain JA-3-3Ab) (Cyanobacteria bacterium Yellowstone A-Prime)
Taxonomic identifieri321327 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000008818 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000884461 – 377Adaptive-response sensory-kinase SasAAdd BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei157Phosphohistidine; by autocatalysisUniRule annotation1

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with KaiC. Participates in the KaiABC complex, whose core is composed of a KaiC homohexamer, a KaiB dimer and two KaiA dimers.UniRule annotation

Protein-protein interaction databases

STRINGi321327.CYA_0637.

Structurei

3D structure databases

ProteinModelPortaliQ2JWK9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini154 – 373Histidine kinaseUniRule annotationAdd BLAST220

Sequence similaritiesi

Contains 1 histidine kinase domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
HOGENOMiHOG000233315.
KOiK08479.
OMAiAHYGQIW.
OrthoDBiPOG091H0M9D.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
3.40.30.10. 1 hit.
HAMAPiMF_01837. Kinase_SasA. 1 hit.
InterProiIPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR011649. KaiB_domain.
IPR023527. Kinase_SasA.
IPR004358. Sig_transdc_His_kin-like_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF07689. KaiB. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM01248. KaiB. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF52833. SSF52833. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2JWK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTSLDRTST RSGIRLLLFA QGRANIEELA EQLRRHIQGL PGQHPAHLKV
60 70 80 90 100
VPLEEHPYLA EHYKLVVTPA LVKAEPLPAQ VLAGEDLATQ LEVWWPRWQG
110 120 130 140 150
QAALVSYQEE AGQDPAPPPT TEALLQMSEE VFSLRQERAQ LREQLDFKDR
160 170 180 190 200
VLAMLVHDLR SPLTATALAV ETLQQGREGS LDKAVERQLF EHARQQLRKM
210 220 230 240 250
DSMITDILES ARGSASELRI RAVETQLASL CQPVIEELLP RIQAKQLQFQ
260 270 280 290 300
ADIPVDLPTV HVDPDKIRQV IFNLLDNAIK YTPAGGSIRL NILHRTSQKV
310 320 330 340 350
QVTVSDTGPG IPEAEQENIF SDAVRLSRDQ QQEGYGIGLS LCRRIVRAHY
360 370
GQIWVESILG KGSSFHFTLP VYRLCGR
Length:377
Mass (Da):42,357
Last modified:March 7, 2006 - v1
Checksum:iC31F74470EEB9501
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000239 Genomic DNA. Translation: ABC98850.1.
RefSeqiWP_011429533.1. NC_007775.1.

Genome annotation databases

EnsemblBacteriaiABC98850; ABC98850; CYA_0637.
KEGGicya:CYA_0637.
PATRICi23809537. VBISynSp90045_0633.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000239 Genomic DNA. Translation: ABC98850.1.
RefSeqiWP_011429533.1. NC_007775.1.

3D structure databases

ProteinModelPortaliQ2JWK9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi321327.CYA_0637.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABC98850; ABC98850; CYA_0637.
KEGGicya:CYA_0637.
PATRICi23809537. VBISynSp90045_0633.

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
HOGENOMiHOG000233315.
KOiK08479.
OMAiAHYGQIW.
OrthoDBiPOG091H0M9D.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
3.40.30.10. 1 hit.
HAMAPiMF_01837. Kinase_SasA. 1 hit.
InterProiIPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR011649. KaiB_domain.
IPR023527. Kinase_SasA.
IPR004358. Sig_transdc_His_kin-like_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF07689. KaiB. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM01248. KaiB. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF52833. SSF52833. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSASA_SYNJA
AccessioniPrimary (citable) accession number: Q2JWK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 7, 2006
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.