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Q2JWE1

- ASSY_SYNJA

UniProt

Q2JWE1 - ASSY_SYNJA

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Protein
Argininosuccinate synthase
Gene
argG, CYA_0710
Organism
Synechococcus sp. (strain JA-3-3Ab) (Cyanobacteria bacterium Yellowstone A-Prime)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei89 – 891Citrulline By similarity
Binding sitei119 – 1191ATP; via amide nitrogen By similarity
Binding sitei121 – 1211Aspartate By similarity
Binding sitei125 – 1251Aspartate By similarity
Binding sitei125 – 1251Citrulline By similarity
Binding sitei126 – 1261Aspartate By similarity
Binding sitei129 – 1291Citrulline By similarity
Binding sitei177 – 1771Citrulline By similarity
Binding sitei186 – 1861Citrulline By similarity
Binding sitei262 – 2621Citrulline By similarity
Binding sitei274 – 2741Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. argininosuccinate synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSP321327:GHFX-705-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:CYA_0710
OrganismiSynechococcus sp. (strain JA-3-3Ab) (Cyanobacteria bacterium Yellowstone A-Prime)
Taxonomic identifieri321327 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000008818: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 403403Argininosuccinate synthaseUniRule annotation
PRO_0000263985Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi321327.CYA_0710.

Structurei

3D structure databases

ProteinModelPortaliQ2JWE1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2JWE1-1 [UniParc]FASTAAdd to Basket

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MGRAKKVVLA YSGGVDTSVC IPYLKHEWGV ESVVTLAVDL GQGAELEAIQ    50
AKALRAGAEQ SLVREAVQTL IADYAFPAIQ ANALYEQRYP LSTALARPLI 100
AQLLVEVAEE VGADAVAHGC TGKGNDQVRF DLAIAALNPK LKVLAPAREW 150
GMTREETIAY GERYGIPMPV QKSSPYSIDL NILGRSVEAG ILEDADQEPP 200
EEVYALTRSI AQTPDEPAYV EIAFEEGIPV ELDGQRLGPR ALFERLNALA 250
GSHGVGRIDM IEDRLVGIKS REIYECPALT VLIQAHRELE SLTLTREVLH 300
YKYGIETTYS QLVYNGLWYS PLREALDAFI RTTQKSVTGV VRMRLHKGQA 350
VCVGRRSPYS LYNAELATYG EGDQFDHRAA EGFIYIWGLP TRTWAQVHRG 400
SGA 403
Length:403
Mass (Da):44,315
Last modified:March 7, 2006 - v1
Checksum:i2DEA545CD0C489CC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000239 Genomic DNA. Translation: ABC98922.1.
RefSeqiWP_011429604.1. NC_007775.1.
YP_474185.1. NC_007775.1.

Genome annotation databases

EnsemblBacteriaiABC98922; ABC98922; CYA_0710.
GeneIDi3897213.
KEGGicya:CYA_0710.
PATRICi23809687. VBISynSp90045_0706.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000239 Genomic DNA. Translation: ABC98922.1 .
RefSeqi WP_011429604.1. NC_007775.1.
YP_474185.1. NC_007775.1.

3D structure databases

ProteinModelPortali Q2JWE1.
ModBasei Search...

Protein-protein interaction databases

STRINGi 321327.CYA_0710.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC98922 ; ABC98922 ; CYA_0710 .
GeneIDi 3897213.
KEGGi cya:CYA_0710.
PATRICi 23809687. VBISynSp90045_0706.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci SSP321327:GHFX-705-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses."
    Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.
    ISME J. 1:703-713(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JA-3-3Ab.

Entry informationi

Entry nameiASSY_SYNJA
AccessioniPrimary (citable) accession number: Q2JWE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 7, 2006
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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