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Q2JVA7 (Q2JVA7_SYNJA) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-hydroxy-3-methylbut-2-enyl diphosphate reductase HAMAP MF_00191
EC=1.17.1.2 HAMAP MF_00191
Gene names
Name:ispH HAMAP MF_00191
Ordered Locus Names:CYA_1148
OrganismSynechococcus sp. (strain JA-3-3Ab) (Cyanobacteria bacterium Yellowstone A-Prime) [Complete proteome] [HAMAP]
Taxonomic identifier321327 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length426 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00191

Catalytic activity

Dimethylallyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191

Isopentenyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191

Cofactor

Binds 1 3Fe-4S cluster By similarity. HAMAP MF_00191

Pathway

Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1. HAMAP MF_00191

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6. HAMAP MF_00191

Sequence similarities

Belongs to the IspH family. HAMAP MF_00191

Sequences

Sequence LengthMass (Da)Tools
Q2JVA7 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: 37EEE13E9FB1A6A8

FASTA42648,443
        10         20         30         40         50         60 
MPHSQPSSPA SSPQDPRALR KALRSSSNYF AKGFEEHKDQ AQRELQTTYK SPLVEQIRAQ 

        70         80         90        100        110        120 
SYCYRQGDIT IHLAKAFGFC WGVERAVEYA YEARRRFPDR QIWITNEIIH NPLVNRHLQE 

       130        140        150        160        170        180 
MGIRFVEKGP DGKKDFSQIR PEDVVIWPAF GASVSEMEFF RSQGNEIVDT TCPWVSRVWN 

       190        200        210        220        230        240 
QVDKHRAAQF TSVIHGKYNH EETVATSSFA QKYLVVLNLE EAEWVARYIL HGGDAAEFRR 

       250        260        270        280        290        300 
RFGKATSPGF DPDRDLERIG IANQTTMLEG ETRAIAKLFE TTMLRKYGPQ ELDKHFMSFN 

       310        320        330        340        350        360 
TICNATQERQ DAMFELLERP LDVVVVIGGF NSSNTTHLQE IALAKGLPSY HIDGPDCIQP 

       370        380        390        400        410        420 
PNRIRHKPLH QDPIVTEGWL PDGPVQIGIT SGASTPDRVV EEVILRIFAL REQPQTPPQG 


SLPLGF

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References

[1]"Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses."
Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.
ISME J. 1:703-713(2007) [PubMed: 18059494] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JA-3-3Ab.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000239 Genomic DNA. Translation: ABC99336.1.
RefSeqYP_474599.1. NC_007775.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ2JVA7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3898837.
GenomeReviewsGene locus CYA_1148 in contig CP000239_GR.
KEGGcya:CYA_1148.
PATRIC23810565. VBISynSp90045_1137.
TIGRCYA_1148.

Phylogenomic databases

eggNOGCOG0761.
HOGENOMHBG286221.
OMAVQEMQLL.
PhylomeDBQ2JVA7.
ProtClustDBPRK13371.

Enzyme and pathway databases

BioCycSSP321327:CYA_1148-MONOMER.

Family and domain databases

HAMAPMF_00191. IspH.
[Tree]
InterProIPR003451. LytB.
[Graphical view]
KOK03527.
PfamPF02401. LYTB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00216. IspH_lytB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ2JVA7_SYNJA
AccessionPrimary (citable) accession number: Q2JVA7
Entry history
Integrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info