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Q2JV13

- SYL_SYNJA

UniProt

Q2JV13 - SYL_SYNJA

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Synechococcus sp. (strain JA-3-3Ab) (Cyanobacteria bacterium Yellowstone A-Prime)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei627 – 6271ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSP321327:GHFX-1250-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:CYA_1256
OrganismiSynechococcus sp. (strain JA-3-3Ab) (Cyanobacteria bacterium Yellowstone A-Prime)
Taxonomic identifieri321327 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000008818: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 873873Leucine--tRNA ligasePRO_1000009455Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi321327.CYA_1256.

Structurei

3D structure databases

ProteinModelPortaliQ2JV13.
SMRiQ2JV13. Positions 4-809.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionAdd
BLAST
Motifi624 – 6285"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2JV13-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDARYNPPAI ESKWQAHWRE LGLDRTPELT AESRKFYALS MFPYPSGSLH
60 70 80 90 100
MGHVRNYTIT DVIARHKRMQ GYAVLHPMGW DAFGLPAENA AIDRGIPPAK
110 120 130 140 150
WTYQNIAQMR DQLQRLGLSY DWEREITTCA PDYYKWTQWL FLQFFKAGLA
160 170 180 190 200
YQKEAPVNWD PVDQTVLANE QVDAEGRSWR SGALVEKRLL KQWFLKITAY
210 220 230 240 250
ADQLLADLEK LSGWPERVLT MQENWIGQSV GARVVFKTET GEELPVFTTR
260 270 280 290 300
PDTLWGATFM VLAPEHPLVE KLTTPEQEVA VKAYRAEAAA RSEIERSAED
310 320 330 340 350
REKTGVWTGS YAINPVNQER IPIWIADYVL MGYGTGAIMA VPAHDQRDFE
360 370 380 390 400
FARQFGLPIK LVVQPPQGGV TSAEDLQAAW TGEGVLINSG PLNGIPVGKG
410 420 430 440 450
PGQSVERAIA WLEEQGLGER QVNYRLRDWL ISRQRYWGCP IPIIHCPHCG
460 470 480 490 500
IVPVPEEDLP VLLPEDVELT GRGGSPLAQL EDWVKVKCPA CGADARRETD
510 520 530 540 550
TMDTFICSSW YFLRFSDPRN DREIFRKDLV NAWLPVDQYV GGIEHAILHL
560 570 580 590 600
LYSRFFTKVL RDLGLLNFDE PFSRLLTQGM VQARTYYNPN KSGKDRWIPT
610 620 630 640 650
ALVKDPNDPR DPETGEPLQV IYATMSKSKG NGVDPEEVLA NYGADTARMF
660 670 680 690 700
ILFKAPPEKD LEWDDADVEG QFRFLNRVWR QVYEFVVRGS GTESLQGKAA
710 720 730 740 750
ELLQAKVEAG SLTKAERDLR RAVHTAIKEV SEDLEEYQFN TAIAGLMKLS
760 770 780 790 800
NALAEAEIPD SPVYAEGIRT LVLLLAPFAP HMAEELWQAL GGTDSVHRQA
810 820 830 840 850
WPTYDPAALV ADTVTIVVQV NGKLRGSFEA PADVTPQEQE RLALQSEAAQ
860 870
RYLQGMTPKR VIVVPKKLVN LVV
Length:873
Mass (Da):98,433
Last modified:March 7, 2006 - v1
Checksum:i14D89A03BC66321F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000239 Genomic DNA. Translation: ABC99439.1.
RefSeqiWP_011430119.1. NC_007775.1.
YP_474702.1. NC_007775.1.

Genome annotation databases

EnsemblBacteriaiABC99439; ABC99439; CYA_1256.
GeneIDi3899407.
KEGGicya:CYA_1256.
PATRICi23810792. VBISynSp90045_1247.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000239 Genomic DNA. Translation: ABC99439.1 .
RefSeqi WP_011430119.1. NC_007775.1.
YP_474702.1. NC_007775.1.

3D structure databases

ProteinModelPortali Q2JV13.
SMRi Q2JV13. Positions 4-809.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 321327.CYA_1256.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC99439 ; ABC99439 ; CYA_1256 .
GeneIDi 3899407.
KEGGi cya:CYA_1256.
PATRICi 23810792. VBISynSp90045_1247.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SSP321327:GHFX-1250-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses."
    Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.
    ISME J. 1:703-713(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JA-3-3Ab.

Entry informationi

Entry nameiSYL_SYNJA
AccessioniPrimary (citable) accession number: Q2JV13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 7, 2006
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3