Q2JUV6 (DAPF_SYNJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Diaminopimelate epimerase
Short name=DAP epimerase
EC=5.1.1.7

Gene names

Name:	dapF
Ordered Locus Names:	CYA_1324

Organism

Synechococcus sp. (strain JA-3-3Ab) (Cyanobacteria bacterium Yellowstone A-Prime) [Complete proteome] [HAMAP]

Taxonomic identifier

321327 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	285 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate. HAMAP MF_00197
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1. HAMAP MF_00197
Subcellular location	Cytoplasm By similarity HAMAP MF_00197.
Sequence similarities	Belongs to the diaminopimelate epimerase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lysine biosynthetic process via diaminopimelate Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	diaminopimelate epimerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 285	285	Diaminopimelate epimerase HAMAP MF_00197		PRO_1000011974
Sites
	Active site	77	1	By similarity
	Active site	228	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2JUV6 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: CFB642301E25C636	FASTA	285	30,869
	10 20 30 40 50 60 MPSRLSFHKY QGLGNDFILV DNRHQPQPCL TPEEAVALCN RRFGVGADGV IFLLPGQEGA 70 80 90 100 110 120 DFSMRLFNSD GSEAEMCGNG IRCLARFLQD LGIPGQDGAY QIHTLAGRIV PQVRPDGLVT 130 140 150 160 170 180 VDMGIPRLLA GQIPTTLAKP EEKVVRQPLQ VGGREWAVTA VSMGNPHCVV FLEEGGSLEE 190 200 210 220 230 240 LDLERVGPLF EHHPAFPERT NTEFAQVLGP NYLRLRVWER GAGVTLACGT GACAALVAAV 250 260 270 280 LEERAEPQAT VELPGGNLEI RWDPDTQHVW MTGPALPVFS GTTAE

References

[1]

"Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses." Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F. ISME J. 1:703-713(2007) [PubMed: 18059494] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JA-3-3Ab.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000239 Genomic DNA. Translation: ABC99501.1.
RefSeq	YP_474764.1. NC_007775.1.
3D structure databases
HSSP	HSSP built from PDB template 2GKE based on UniProtKB P44859.
ProteinModelPortal	Q2JUV6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2JUV6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3899492.
GenomeReviews	Gene locus CYA_1324 in contig CP000239_GR.
KEGG	cya:CYA_1324.
PATRIC	23810940. VBISynSp90045_1321.
TIGR	CYA_1324.
Phylogenomic databases
eggNOG	COG0253.
HOGENOM	HBG399442.
OMA	FMTGPAT.
PhylomeDB	Q2JUV6.
ProtClustDB	PRK00450.
Enzyme and pathway databases
BioCyc	SSP321327:CYA_1324-MONOMER.
Family and domain databases
HAMAP	MF_00197. DAP_epimerase. [Tree]
InterPro	IPR018510. DAP_epimerase_AS. IPR001653. DAP_epimerase_DapF. [Graphical view]
KO	K01778.
Pfam	PF01678. DAP_epimerase. 2 hits. [Graphical view]
TIGRFAMs	TIGR00652. DapF. 1 hit.
PROSITE	PS01326. DAP_EPIMERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPF_SYNJA

Accession

Primary (citable) accession number: Q2JUV6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program