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Protein

Glutamyl-tRNA(Gln) amidotransferase subunit A

Gene

gatA

Organism
Synechococcus sp. (strain JA-3-3Ab) (Cyanobacteria bacterium Yellowstone A-Prime)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).UniRule annotation

Catalytic activityi

ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei75 – 751Charge relay systemUniRule annotation
Active sitei150 – 1501Charge relay systemUniRule annotation
Active sitei174 – 1741Acyl-ester intermediateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSP321327:GHFX-1411-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamyl-tRNA(Gln) amidotransferase subunit AUniRule annotation (EC:6.3.5.7UniRule annotation)
Short name:
Glu-ADT subunit AUniRule annotation
Gene namesi
Name:gatAUniRule annotation
Ordered Locus Names:CYA_1419
OrganismiSynechococcus sp. (strain JA-3-3Ab) (Cyanobacteria bacterium Yellowstone A-Prime)
Taxonomic identifieri321327 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
Proteomesi
  • UP000008818 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Glutamyl-tRNA(Gln) amidotransferase subunit APRO_0000241164Add
BLAST

Interactioni

Subunit structurei

Heterotrimer of A, B and C subunits.UniRule annotation

Protein-protein interaction databases

STRINGi321327.CYA_1419.

Structurei

3D structure databases

ProteinModelPortaliQ2JUM6.
SMRiQ2JUM6. Positions 4-479.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the amidase family. GatA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3P. Bacteria.
COG0154. LUCA.
HOGENOMiHOG000116699.
KOiK02433.
OMAiKEYFGAG.
OrthoDBiPOG091H00O9.

Family and domain databases

Gene3Di3.90.1300.10. 1 hit.
HAMAPiMF_00120. GatA. 1 hit.
InterProiIPR000120. Amidase.
IPR020556. Amidase_CS.
IPR023631. Amidase_dom.
IPR004412. GatA.
[Graphical view]
PANTHERiPTHR11895. PTHR11895. 1 hit.
PfamiPF01425. Amidase. 1 hit.
[Graphical view]
SUPFAMiSSF75304. SSF75304. 1 hit.
TIGRFAMsiTIGR00132. gatA. 1 hit.
PROSITEiPS00571. AMIDASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2JUM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVIRALHRQ LVTKERSAEE IAREYLERLA QLEPQLKSFI TVTEELALQQ
60 70 80 90 100
AKAVDARIRA GEEIGPLAGI PLAVKDNLCT QGIRTTCASR MLEGFIPPYE
110 120 130 140 150
STVTARLAAA GMVTVGKTNL DEFAMGSSTE NSAFQRTANP WDLTRVPGGS
160 170 180 190 200
SGGSAAAVAA DQAVVALGSD TGGSIRQPAA FCGVVGLKPT YGLVSRYGLV
210 220 230 240 250
AFASSLDQVG PFGRTVEDVA LLLQGIAGHD PLDSTSLKVE IPDYSQALIP
260 270 280 290 300
EIKGFKIGVI RDLLGEGCGE ETRAAVQAAI QHLEELGAEI LEIDCPSFRY
310 320 330 340 350
GLATYYIIAP SEASSNLARY DGVKYGLREP ADSLLAMYGK TRARGFGPEV
360 370 380 390 400
KRRIMIGTYA LSAGYYDAYY LKAQKVRTLI KQDFLRAFEK VDVLVSPTTP
410 420 430 440 450
TPAFKAGERE DPLSMYLCDL MTIPVNLAGL PGLSLPCGFA NGLPIGLQII
460 470 480 490 500
GNVLQESKVL RVAYAYEQST DWHKRRPPLG QPPLEQAQGT AQQPKAKSKS

TKGSKKSKS
Length:509
Mass (Da):54,662
Last modified:March 7, 2006 - v1
Checksum:iE280F34CED2647EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000239 Genomic DNA. Translation: ABC99588.1.
RefSeqiWP_011430266.1. NC_007775.1.

Genome annotation databases

EnsemblBacteriaiABC99588; ABC99588; CYA_1419.
KEGGicya:CYA_1419.
PATRICi23811132. VBISynSp90045_1412.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000239 Genomic DNA. Translation: ABC99588.1.
RefSeqiWP_011430266.1. NC_007775.1.

3D structure databases

ProteinModelPortaliQ2JUM6.
SMRiQ2JUM6. Positions 4-479.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi321327.CYA_1419.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABC99588; ABC99588; CYA_1419.
KEGGicya:CYA_1419.
PATRICi23811132. VBISynSp90045_1412.

Phylogenomic databases

eggNOGiENOG4105C3P. Bacteria.
COG0154. LUCA.
HOGENOMiHOG000116699.
KOiK02433.
OMAiKEYFGAG.
OrthoDBiPOG091H00O9.

Enzyme and pathway databases

BioCyciSSP321327:GHFX-1411-MONOMER.

Family and domain databases

Gene3Di3.90.1300.10. 1 hit.
HAMAPiMF_00120. GatA. 1 hit.
InterProiIPR000120. Amidase.
IPR020556. Amidase_CS.
IPR023631. Amidase_dom.
IPR004412. GatA.
[Graphical view]
PANTHERiPTHR11895. PTHR11895. 1 hit.
PfamiPF01425. Amidase. 1 hit.
[Graphical view]
SUPFAMiSSF75304. SSF75304. 1 hit.
TIGRFAMsiTIGR00132. gatA. 1 hit.
PROSITEiPS00571. AMIDASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGATA_SYNJA
AccessioniPrimary (citable) accession number: Q2JUM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 7, 2006
Last modified: September 7, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.