Q2JUC0 (CYSC_SYNJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylyl-sulfate kinase
EC=2.7.1.25

Alternative name(s):
APS kinase
ATP adenosine-5'-phosphosulfate 3'-phosphotransferase
Adenosine-5'-phosphosulfate kinase

Gene names

Name:	cysC
Ordered Locus Names:	CYA_1535

Organism

Synechococcus sp. (strain JA-3-3Ab) (Cyanobacteria bacterium Yellowstone A-Prime) [Complete proteome] [HAMAP]

Taxonomic identifier

321327 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	176 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the synthesis of activated sulfate. HAMAP MF_00065
Catalytic activity	ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate. HAMAP MF_00065
Pathway	Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3. HAMAP MF_00065
Sequence similarities	Belongs to the APS kinase family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	sulfate assimilation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylylsulfate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 176	176	Adenylyl-sulfate kinase HAMAP MF_00065		PRO_1000057446
Regions
	Nucleotide binding	12 – 19	8	ATP By similarity
Sites
	Active site	86	1	Phosphoserine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2JUC0 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: E58C17C071C70786	FASTA	176	19,629
	10 20 30 40 50 60 MGRRGVTVWF TGLSGAGKTT LSCGVAQQLQ ALGLPVEVLD GDLVRQHLSK ELGFSRADRD 70 80 90 100 110 120 ENVRRIGFVA EMLTRHGVIV LVSAISPYRA TRQEVRQQIG NFIEVFVDAP LEVCEQRDVK 130 140 150 160 170 GLYRKARAGL IRHFTGIDDP YEPPEYPEVV CKTAEQSISE CIDLVMQSLR SHGYLQ

References

[1]

"Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses." Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F. ISME J. 1:703-713(2007) [PubMed: 18059494] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JA-3-3Ab.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000239 Genomic DNA. Translation: ABC99700.1.
RefSeq	YP_474963.1. NC_007775.1.
3D structure databases
ProteinModelPortal	Q2JUC0.
SMR	Q2JUC0. Positions 2-175.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2JUC0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3897141.
GenomeReviews	Gene locus CYA_1535 in contig CP000239_GR.
KEGG	cya:CYA_1535.
PATRIC	23811356. VBISynSp90045_1522.
TIGR	CYA_1535.
Phylogenomic databases
eggNOG	COG0529.
HOGENOM	HBG309946.
OMA	LAGEIPH.
PhylomeDB	Q2JUC0.
ProtClustDB	PRK00889.
Enzyme and pathway databases
BioCyc	SSP321327:CYA_1535-MONOMER.
Family and domain databases
HAMAP	MF_00065. Adenylyl_sulf_kinase. [Tree]
InterPro	IPR002891. APS_kinase_C. [Graphical view]
KO	K00860.
Pfam	PF01583. APS_kinase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00455. ApsK. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CYSC_SYNJA

Accession

Primary (citable) accession number: Q2JUC0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program