Q2JTG5 (HIS8_SYNJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histidinol-phosphate aminotransferase
EC=2.6.1.9

Alternative name(s):
Imidazole acetol-phosphate transaminase

Gene names

Name:	hisC
Ordered Locus Names:	CYA_1885

Organism

Synechococcus sp. (strain JA-3-3Ab) (Cyanobacteria bacterium Yellowstone A-Prime) [Complete proteome] [HAMAP]

Taxonomic identifier

321327 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	353 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01023
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity. HAMAP MF_01023
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-phenylalanine:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 353	353	Histidinol-phosphate aminotransferase HAMAP MF_01023		PRO_0000319792
Amino acid modifications
	Modified residue	218	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2JTG5 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: B1EE72A66264764C	FASTA	353	39,543
	10 20 30 40 50 60 MCALRYLRPD LLHLKPYDAV PPQAADKLDA NEFPWDWPVG FKQKLSLLWE KGIPSNRYPD 70 80 90 100 110 120 AHHQGLKQAI AAYAGADPAQ ISLGNGSDEL IRSLLIATCV GERGSVLVAE PTFSMYAILA 130 140 150 160 170 180 QSLGIPVVRV PRHPETFALD LGRCQQAVAE QRVRVVCLVD PNSPTGNGLS TAEWEWVEGL 190 200 210 220 230 240 PAEILVILDE AYFEFSQHTA LPKLAEHPNW VILRTFSKAF RLAAHRVGYA IGHPQLIQVL 250 260 270 280 290 300 DSIRLPYNLS AISQWAVQIA LEHAEEFLAD LPLIRQERDA LYQALQELPG VRVWPSQANF 310 320 330 340 350 LYFRVAGWDP QDLQRAWQEL GTCVRCTGGG LRLTVGTPEE NQRALERLRQ ILR

References

[1]

"Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses." Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F. ISME J. 1:703-713(2007) [PubMed: 18059494] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JA-3-3Ab.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000239 Genomic DNA. Translation: ABD00032.1.
RefSeq	YP_475295.1. NC_007775.1.
3D structure databases
ProteinModelPortal	Q2JTG5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2JTG5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3899787.
GenomeReviews	Gene locus CYA_1885 in contig CP000239_GR.
KEGG	cya:CYA_1885.
PATRIC	23812046. VBISynSp90045_1860.
TIGR	CYA_1885.
Phylogenomic databases
eggNOG	COG0079.
HOGENOM	HBG646350.
OMA	WANPADA.
PhylomeDB	Q2JTG5.
ProtClustDB	PRK02610.
Enzyme and pathway databases
BioCyc	SSP321327:CYA_1885-MONOMER.
Family and domain databases
HAMAP	MF_01023. HisC_aminotrans_2. [Tree]
InterPro	IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00817.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01141. HisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS8_SYNJA

Accession

Primary (citable) accession number: Q2JTG5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program