Q2JTA2 (Q2JTA2_SYNJA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase HAMAP MF_00388
EC=3.5.1.- HAMAP MF_00388

Alternative name(s):
UDP-3-O-acyl-GlcNAc deacetylase HAMAP MF_00388

Gene names

Name:	lpxC HAMAP MF_00388
Ordered Locus Names:	CYA_1955

Organism

Synechococcus sp. (strain JA-3-3Ab) (Cyanobacteria bacterium Yellowstone A-Prime) [Complete proteome] [HAMAP]

Taxonomic identifier

321327 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00388
Catalytic activity	UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H2O = UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine + acetate. HAMAP MF_00388
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6. HAMAP MF_00388
Sequence similarities	Belongs to the LpxC family. HAMAP MF_00388

Ontologies

Keywords
Biological process	Lipid A biosynthesis HAMAP MF_00388 Lipid synthesis
Molecular function	Hydrolase HAMAP MF_00388 EMBL ABD00100.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q2JTA2 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: D2EEC9503E6A0F6B	FASTA	303	32,692
	10 20 30 40 50 60 MREQQHTLAS SISLEGVGLH TGLPVRCSLH PAPASSGRVF VRVDQRGSPP IPARLGSLAP 70 80 90 100 110 120 AALCTRLQQG SPPVQVQTVE HLLAALYVLG IDNCRIEVEG PELPILDGSA LPFVEAVAQA 130 140 150 160 170 180 GILAQEQPAL LGVIQEPVTV WAGEAFVSAV PYPGFRFTYG IDFADCPIGQ QWLSWRENRA 190 200 210 220 230 240 DFVQSIAPAR TFARQQDAEL AHQQGLIQGG SLENAIVCSK TEWLGPLRFP DEPVRHKLID 250 260 270 280 290 300 LLGDLSLLGC RLQGHIVAYK AGHALHHRLA EQLLKSGSLQ VEPAQEQARD PLCLGGVESR SSF

References

[1]

"Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses." Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F. ISME J. 1:703-713(2007) [PubMed: 18059494] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JA-3-3Ab.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000239 Genomic DNA. Translation: ABD00100.1.
RefSeq	YP_475363.1. NC_007775.1.
3D structure databases
ProteinModelPortal	Q2JTA2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2JTA2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3899646.
GenomeReviews	Gene locus CYA_1955 in contig CP000239_GR.
KEGG	cya:CYA_1955.
PATRIC	23812182. VBISynSp90045_1927.
TIGR	CYA_1955.
Phylogenomic databases
eggNOG	COG0774.
HOGENOM	HBG482342.
OMA	KAYKSGH.
PhylomeDB	Q2JTA2.
ProtClustDB	PRK13186.
Enzyme and pathway databases
BioCyc	SSP321327:CYA_1955-MONOMER.
Family and domain databases
HAMAP	MF_00388. LpxC. [Tree]
InterPro	IPR020568. Ribosomal_S5_D2-typ_fold. IPR004463. UDP-acyl_GlcNac_deAcase. IPR011334. UDP-acyl_GlcNac_deAcase_C. IPR015870. UDP-acyl_N-AcGlcN_deAcase_N. [Graphical view]
Gene3D	G3DSA:3.30.1700.10. UDP-acyl_N-AcGlcN_deAcase_C. 1 hit. G3DSA:3.30.230.20. UDP-acyl_N-AcGlcN_deAcase_N. 1 hit.
KO	K02535.
Pfam	PF03331. LpxC. 1 hit. [Graphical view]
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 2 hits.
TIGRFAMs	TIGR00325. LpxC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q2JTA2_SYNJA

Accession

Primary (citable) accession number: Q2JTA2

Entry history

Integrated into UniProtKB/TrEMBL:	March 7, 2006
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)