ID   GLGA1_SYNJA             Reviewed;         491 AA.
AC   Q2JSZ9;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   27-MAR-2024, entry version 88.
DE   RecName: Full=Glycogen synthase 1 {ECO:0000255|HAMAP-Rule:MF_00484};
DE            EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE   AltName: Full=Starch [bacterial glycogen] synthase 1 {ECO:0000255|HAMAP-Rule:MF_00484};
GN   Name=glgA1 {ECO:0000255|HAMAP-Rule:MF_00484};
GN   OrderedLocusNames=CYA_2071;
OS   Synechococcus sp. (strain JA-3-3Ab) (Cyanobacteria bacterium Yellowstone
OS   A-Prime).
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales; Synechococcaceae;
OC   Synechococcus.
OX   NCBI_TaxID=321327;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JA-3-3Ab;
RX   PubMed=18059494; DOI=10.1038/ismej.2007.46;
RA   Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N.,
RA   Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.;
RT   "Population level functional diversity in a microbial community revealed by
RT   comparative genomic and metagenomic analyses.";
RL   ISME J. 1:703-713(2007).
CC   -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC       {ECO:0000255|HAMAP-Rule:MF_00484}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC         alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC         COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC         ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC   -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_00484}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC       Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_00484}.
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DR   EMBL; CP000239; ABD00211.1; -; Genomic_DNA.
DR   RefSeq; WP_011430885.1; NC_007775.1.
DR   AlphaFoldDB; Q2JSZ9; -.
DR   SMR; Q2JSZ9; -.
DR   STRING; 321327.CYA_2071; -.
DR   CAZy; GT5; Glycosyltransferase Family 5.
DR   KEGG; cya:CYA_2071; -.
DR   eggNOG; COG0297; Bacteria.
DR   HOGENOM; CLU_009583_18_3_3; -.
DR   OrthoDB; 9808590at2; -.
DR   UniPathway; UPA00164; -.
DR   Proteomes; UP000008818; Chromosome.
DR   GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR   GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd03791; GT5_Glycogen_synthase_DULL1-like; 1.
DR   Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR   HAMAP; MF_00484; Glycogen_synth; 1.
DR   InterPro; IPR001296; Glyco_trans_1.
DR   InterPro; IPR011835; GS/SS.
DR   InterPro; IPR013534; Starch_synth_cat_dom.
DR   NCBIfam; TIGR02095; glgA; 1.
DR   PANTHER; PTHR46083; -; 1.
DR   PANTHER; PTHR46083:SF1; GLYCOGEN SYNTHASE 2-RELATED; 1.
DR   Pfam; PF08323; Glyco_transf_5; 1.
DR   Pfam; PF00534; Glycos_transf_1; 1.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE   3: Inferred from homology;
KW   Glycogen biosynthesis; Glycosyltransferase; Transferase.
FT   CHAIN           1..491
FT                   /note="Glycogen synthase 1"
FT                   /id="PRO_0000241804"
FT   BINDING         15
FT                   /ligand="ADP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:57498"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ   SEQUENCE   491 AA;  57039 MW;  836DE01B097200F9 CRC64;
     MYIVQIASEC APVIKAGGLG DVVYGLSREL EVRGHCVELV LPKYDTMRYD QIWGLHDAYR
     DLWVPWYGGA IHCSVYCGWV HGRLCFFIEP HSGDNFFNRG CYYGCPDDNM RFAFFSKAAL
     EFLLKSNKRP DIIHCHDWQT GLVPVLLFEI YKYHGMENQR VCYTIHNFKH QGFGGPEILW
     ATGLNREPYY FHYDRLRDNF NPFALNFMKG GIVFSNFVTT VSPTHALEAR FGNYNYGLGH
     TLYLHQHKFR GVLNGIDYDI WNPEIDRFIP FHYTAQTLEN KAKNKKALRD QLWLQDVDKP
     IVAYIGRLDE QKGVHLVHHA IYRSLFKNAQ FVLLGSATEP GIGAWFAHEK RYLNDNPDVH
     IELGFNEELS HLIYAGADIL VVPSHYEPCG LTQMIGLKYG TVPVVRGVGG LVDTVFDRDY
     DTRKLPEQRN GYVFYHTDRA ALESALDRAI DLWYTAPDQF RQLQVQGMSY DYSWNYPGKE
     YLEIYEFIRH R
//