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Q2JSS7 (Q2JSS7_SYNJA) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha HAMAP MF_00823
Short name=ACCase subunit alpha HAMAP MF_00823
Short name=Acetyl-CoA carboxylase carboxyltransferase subunit alpha HAMAP MF_00823
EC=6.4.1.2 HAMAP MF_00823
Gene names
Name:accA HAMAP MF_00823
Ordered Locus Names:CYA_2152
OrganismSynechococcus sp. (strain JA-3-3Ab) (Cyanobacteria bacterium Yellowstone A-Prime) [Complete proteome] [HAMAP]
Taxonomic identifier321327 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA By similarity. HAMAP MF_00823

Catalytic activity

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. HAMAP MF_00823

Pathway

Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. HAMAP MF_00823

Subunit structure

Acetyl-CoA carboxylase is an heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD) By similarity. HAMAP MF_00823

Subcellular location

Cytoplasm By similarity HAMAP MF_00823.

Sequence similarities

Belongs to the AccA family. HAMAP MF_00823

Sequences

Sequence LengthMass (Da)Tools
Q2JSS7 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: A78FB4614CBE31CD

FASTA32736,360
        10         20         30         40         50         60 
MTKPTDRLLL EFEQPVAALE QRIQEIRALA EENDIDASEQ IRQLEAKAEE LRREIFSQLT 

        70         80         90        100        110        120 
PVERLQVARH PRRPTTLDYV QTICDDWFEL HGDRHGQDDP AIVGGLAKLG DQPVMILGHQ 

       130        140        150        160        170        180 
KGRDTKDNIH RNFGMPNPAG YRKALRLMEH AHRFGLPLLT FIDTPGAYPG VKAEAEGQGE 

       190        200        210        220        230        240 
AIATNLQTLF RLEIPIICTV IGEGGSGGAL AIGIGDRILM FEHAVYSVIS PEGCAAILWK 

       250        260        270        280        290        300 
DAKKAPQAAA ALRITAQDLL QLEVIDEILP EPVGGTHRAP LEAAQTLKEA LLRHLKELSA 

       310        320 
LSGRELREER YQKFRRMGAF LELAQES

« Hide

References

[1]"Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses."
Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.
ISME J. 1:703-713(2007) [PubMed: 18059494] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JA-3-3Ab.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000239 Genomic DNA. Translation: ABD00292.1.
RefSeqYP_475555.1. NC_007775.1.

3D structure databases

ProteinModelPortalQ2JSS7.
SMRQ2JSS7. Positions 9-319.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2JSS7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3899102.
GenomeReviewsGene locus CYA_2152 in contig CP000239_GR.
KEGGcya:CYA_2152.
PATRIC23812574. VBISynSp90045_2122.
TIGRCYA_2152.

Phylogenomic databases

eggNOGCOG0825.
HOGENOMHBG286557.
OMAGRDTKDN.
PhylomeDBQ2JSS7.
ProtClustDBPRK05724.

Enzyme and pathway databases

BioCycSSP321327:CYA_2152-MONOMER.

Family and domain databases

HAMAPMF_00823. AcetylCoA_CT_alpha.
[Tree]
InterProIPR001095. Acetyl_CoA_COase_a_su.
IPR011763. COA_CT_C.
[Graphical view]
KOK01962.
PANTHERPTHR22855:SF3. Ac-CoA_carboxylA. 1 hit.
PfamPF03255. ACCA. 1 hit.
[Graphical view]
PRINTSPR01069. ACCCTRFRASEA.
TIGRFAMsTIGR00513. AccA. 1 hit.
PROSITEPS50989. COA_CT_CTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ2JSS7_SYNJA
AccessionPrimary (citable) accession number: Q2JSS7
Entry history
Integrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info