Q2JQW9 (DNAA_SYNJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromosomal replication initiator protein DnaA

Gene names

Name:	dnaA
Ordered Locus Names:	CYA_0001

Organism

Synechococcus sp. (strain JA-3-3Ab) (Cyanobacteria bacterium Yellowstone A-Prime) [Complete proteome] [HAMAP]

Taxonomic identifier

321327 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	467 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP MF_00377
Subcellular location	Cytoplasm By similarity HAMAP MF_00377.
Sequence similarities	Belongs to the DnaA family.

Ontologies

Keywords
Biological process	DNA replication
Cellular component	Cytoplasm
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA-dependent DNA replication initiation Inferred from electronic annotation. Source: InterPro regulation of DNA replication Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA replication origin binding Inferred from electronic annotation. Source: InterPro nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 467	467	Chromosomal replication initiator protein DnaA HAMAP MF_00377		PRO_1000048747
Regions
	Nucleotide binding	167 – 174	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2JQW9 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 3A6B2C3697AB356F	FASTA	467	52,549
	10 20 30 40 50 60 MDISLDRLWD EALGHLQVQL SRPTFEAWIK TARAESLVDN RLTISTPSEW ARGWLQKHYA 70 80 90 100 110 120 STITEVVQRV AGIPLQVEFS VAPQALVEEE APSTAVASTS RKAGSFPASA PLGLEVSGSL 130 140 150 160 170 180 PMRAPDLNPK YSFSRFVVGP NNRMAHAAAL AVADKPGRAY NPLFLCGGVG LGKTHLMQAI 190 200 210 220 230 240 GHYQLEANPR AKVFYVSTER FTNDLIDAIR RDSMQSFREH YRDVDILLVD DIQFIEGKEY 250 260 270 280 290 300 TQEEFFHTFN TLHESGKQIV LAADRSPHLI PRLQERLCSR FSMGLIAEIQ PPDIETRMAI 310 320 330 340 350 360 LKKKAEYEGM ILPPEVIEYI ATTYTSNIRE LEGALIRAVA YVSISGLPMS VETIQPILNP 370 380 390 400 410 420 PSEPKEITPD MIIDVVCEEF GVDRESLLGS SRKRDISQAR QIAMFLMRHH TNLSLPKIGD 430 440 450 460 YFGGKDHTTV LYSCEKVSQL QRENLQFERQ LQNLAQRLRV MANSRNR

References

[1]

"Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses." Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F. ISME J. 1:703-713(2007) [PubMed: 18059494] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JA-3-3Ab.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000239 Genomic DNA. Translation: ABC98234.1.
RefSeq	YP_473497.1. NC_007775.1.
3D structure databases
ProteinModelPortal	Q2JQW9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2JQW9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3897189.
GenomeReviews	Gene locus CYA_0001 in contig CP000239_GR.
KEGG	cya:CYA_0001.
PATRIC	23808263. VBISynSp90045_0001.
TIGR	CYA_0001.
Phylogenomic databases
eggNOG	COG0593.
HOGENOM	HBG695666.
OMA	CHTLNAL.
PhylomeDB	Q2JQW9.
ProtClustDB	PRK00149.
Enzyme and pathway databases
BioCyc	SSP321327:CYA_0001-MONOMER.
Family and domain databases
HAMAP	MF_00377. DnaA_bact. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013159. DnaA_C. IPR013317. DnaA_Hda. IPR010921. Trp_repressor/repl_initiator. [Graphical view]
Gene3D	G3DSA:1.10.1750.10. DnaA_C. 1 hit.
KO	K02313.
Pfam	PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. [Graphical view]
PRINTS	PR00051. DNAA.
SMART	SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. [Graphical view]
SUPFAM	SSF48295. Trp_repress_rep. 1 hit.
TIGRFAMs	TIGR00362. DnaA. 1 hit.
PROSITE	PS01008. DNAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNAA_SYNJA

Accession

Primary (citable) accession number: Q2JQW9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program